New Azulene-Type Sesquiterpenoids from the Fruiting Bodies of Lactarius deliciosus

Tala, Michel Feussi; Qin, Jianchun; Ndongo, Joseph Thierry; Laatsch, Hartmut

doi:10.1007/s13659-017-0130-1

Cited by 18 publications

(11 citation statements)

References 14 publications

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“…For instance, a PTP1B inhibitor, (24E)-3,4-seco-cucurbita-4,24-diene-3-hydroxy-26,29-dioic acid, is extracted from the sporocarps of Russula lepida , and has potential uses in treating type-2 diabetes and obesity 1 . Metabolites of many Lactarius species have potential antitumor and antiviral activities 2 . Auricularia auricula polysaccharides were reported to have potent antioxidant activities against hydroxyl and superoxide radicals 3 .…”

Section: Introductionmentioning

confidence: 99%

The Genome Sequences of 90 Mushrooms

Ma³

et al. 2018

Sci Rep

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Macrofungus is defined as the fungus that grows an observable sporocarp. The sporocarps of many species are commonly called mushrooms and consumed by people all around the world as food and/or medicine. Most macrofungi belong to the divisions Basidiomycetes and Ascomycetes, which are estimated to contain more than 80,000 species in total. We report the draft genome assemblies of macrofungi (83 Basidiomycetes species and 7 Ascomycetes species) based on Illumina sequencing. The genome sizes of these species ranged from 27.4 Mb (Hygrophorus russula) to 202.2 MB (Chroogomphus rutilus). The numbers of protein-coding genes were predicted in the range of 9,511 (Hygrophorus russula) to 52,289 (Craterellus lutescens). This study provides the largest genomic dataset for macrofungi species. This resource will facilitate the artificial cultivation of edible mushrooms and the discovery of novel drug candidates.

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Section: Introductionmentioning

confidence: 99%

The Genome Sequences of 90 Mushrooms

Ma³

et al. 2018

Sci Rep

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“…In addition, sesquiterpenoid compounds having an azulene skeleton were identified in L. deliciosus. One of the compounds, 7-acetyl-4-methylazulene-1-carbaldehyde, was found to show antibacterial activity against S. aureus [118]. Another azulene derivative, 7-acetyl-4-methylazulene-1-carboxylic acid, was detected in Lactarius salmonicolor [115].…”

Section: Azulenesmentioning

confidence: 99%

Culinary–medicinal mushrooms: a review of organic compounds and bioelements with antioxidant activity

Podkowa

Kryczyk-Poprawa

Opoka

et al. 2020

Eur Food Res Technol

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There are about 3000 species of mushrooms, which have a high amount of substances that are beneficial to human health, such as antioxidants. It is well known that oxidative stress plays an important role in the etiopathogenesis of many diseases, including cancer, cardiovascular disorders, and diseases of the central nervous system. One way to prevent homeostasis disorders that occur as a result of excessive production of pro-oxidative substances is to include the ingredients having antioxidant properties in the diet. Several compounds, such as those with phenolic and indole derivatives as well as carotenoids and some vitamins, exhibit antioxidant activity. These substances are present in many foods, including mushrooms. In addition, they have certain unique compounds that are not found in other sources (e.g., norbadione A). The present work discusses selected ingredients exhibiting antioxidant activity, which are found in various species of mushrooms as wells as describes the content of these compounds in the extracts obtained from mushrooms using artificial digestive juice.

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“…Owing to its excellent taste, texture, and flavor, L. deliciosus is popular in China, with some chemical substances and bioactivities of L. deliciosus being reported. Research has shown that sesquiterpenoids contribute to the unique color of L. deliciosus , some of which possess potent biological activities such as antimicrobial and anticancer [10,11,12]. Ding et al and Hou et al reported that L. deliciosus polysaccharides exhibited significant anti-tumor activity in mice in vivo and immunomodulatory effects through proliferative growth of both B cell and macrophages cell in vitro [13,14].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition, Antioxidant and Antihyperglycemic Activities of the Wild Lactarius deliciosus from China

Feng

et al. 2019

Molecules

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The wild mushroom Lactarius deliciosus from China was studied for the first time to obtain information about its chemical composition, antioxidant, and antihyperglycemic activities. Nutritional value, dietary fiber, fatty acids, metal elements, free sugars, free amino acids, organic acids, flavor 5′-nucleotides, and volatile aroma compounds were determined. Potential antioxidant and antihyperglycemic activities were also tested by investigating 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals scavenging activities, ferric ion reducing activity, as well as α-amylase and α-glucosidase inhibitory activities using ethanol and aqueous extracts. The results showed that L. deliciosus was a good wild mushroom with high protein, carbohydrate, and dietary fiber contents, while low in fat and calorie, extensive unsaturated fatty acids contents, with negligible health risks about harmful metal elements. Twenty kinds of free amino acids were detected with a total content 3389.45 mg per 100 g dw. Flavor 5′-nucleotides including 5′-CMP, 5′-UMP, 5′-IMP, and 5′-AMP were 929.85, 45.21, 311.75, and 14.49 mg per 100 g dw, respectively. Mannitol (7825.00 mg per 100 g dw) was the main free sugar, and quininic acid (729.84 mg per 100 g dw) was the main organic acid. Twenty-five kinds of volatile aroma compounds were identified, acids (84.23%) were the most abundant compounds based on content, while aldehydes (15 of 25) were the most abundant compounds based on variety. In addition, both ethanol and aqueous extracts from L. deliciosus exhibited excellent antioxidant activity. While in antihyperglycemic activity tests, only ethanol extracts showed inhibitory effects on α-amylase and α-glucosidase.

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New Azulene-Type Sesquiterpenoids from the Fruiting Bodies of Lactarius deliciosus

Cited by 18 publications

References 14 publications

The Genome Sequences of 90 Mushrooms

The Genome Sequences of 90 Mushrooms

Culinary–medicinal mushrooms: a review of organic compounds and bioelements with antioxidant activity

Chemical Composition, Antioxidant and Antihyperglycemic Activities of the Wild Lactarius deliciosus from China

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