Quantitative <i>T</i><sub>2</sub>* relaxation time analysis of articular cartilage of the tibiotalar joint in professional football players and healthy volunteers at 3T MRI

Behzadi, Cyrus; Maas, Kai-Jonathan; Welsch, Goetz H.; Kaul, Michael; Schoen, Gerhard; Laqmani, Azien; Adam, Gerhard; Regier, Marc

doi:10.1002/jmri.25757

“…7). These results are consistent with previous clinical studies which reported increased T2* relaxation time on the regions of increased articular cartilage contact loads [37][38][39]. Although those clinical measurements must be the result of long-term response to altered joint loading, our relatively short three-month study suggests that the changes in the articular cartilage extracellular matrix may be initiated at the early stage of load variations.…”

Section: Discussionsupporting

confidence: 92%

Alterations in articular cartilage T2 star relaxation time following mechanical disorders: in vivo canine supraspinatus tendon resection models

Lee

¹

,

Hong

²

,

Lim

³

et al. 2020

BMC Musculoskelet Disord

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Background: The role of altered joint mechanics on cartilage degeneration in in vivo models has not been studied successfully due to a lack of pre-injury information. We aimed 1) to develop an accurate in vivo canine model to measure the changes in joint loading and T2 star (T2*) relaxation time before and after unilateral supraspinatus tendon resections, and 2) to find the relationship between regional variations in articular cartilage loading patterns and T2* relaxation time distributions. Methods: Rigid markers were implanted in the scapula and humerus of tested dogs. The movement of the shoulder bones were measured by a motion tracking system during normal gaits. In vivo cartilage contact strain was measured by aligning 3D shoulder models with the motion tracking data. Articular cartilage T2* relaxation times were measured by quantitative MRI scans. Articular cartilage contact strain and T2* relaxation time were compared in the shoulders before and 3 months after the supraspinatus tendon resections. Results: Excellent accuracy and reproducibility were found in our in vivo contact strain measurements with less than 1% errors. Changes in articular cartilage contact strain exhibited similar patterns with the changes in the T2* relaxation time after resection surgeries. Regional changes in the articular cartilage T2* relaxation time exhibited positive correlations with regional contact strain variations 3 months after the supraspinatus resection surgeries. Conclusion: This is the first study to measure in vivo articular cartilage contact strains with high accuracy and reproducibility. Positive correlations between contact strain and T2* relaxation time suggest that the articular cartilage extracellular matrix may responds to mechanical changes in local areas.

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“…It was further supported by positive correlations between regional variations in articular cartilage contact strain and T2* relaxation time (Fig 7). These results are consistent with previous clinical studies which reported increased T2* relaxation time on the regions of increased articular cartilage contact loads [37][38][39]. Although those clinical measurements must be the result of long-term response to altered joint loading, our relatively short three-month study suggests that the changes in the articular cartilage extracellular matrix may be initiated at the early stage of load variations.…”

Section: Discussionsupporting

confidence: 92%

Alterations in articular cartilage T2 star relaxation time following mechanical disorders: in vivo canine supraspinatus tendon resection models

Lee¹,

Hong²,

Lim

³

et al. 2020

Preprint

0

View full text Add to dashboard Cite

Abstract Background: The role of altered joint mechanics on cartilage degeneration in in vivo models has not been studied successfully due to a lack of pre-injury information. We aimed 1) to develop an accurate in vivo canine model to measure the changes in joint loading and T2 star (T2*) relaxation time before and after unilateral supraspinatus tendon resections, and 2) to find the relationship between regional variations in articular cartilage loading patterns and T2* relaxation time distributions.Methods: Rigid markers were implanted in the scapula and humerus of tested dogs. The movement of the shoulder bones were measured by a motion tracking system during normal gaits. In vivo cartilage contact strain was measured by aligning 3D shoulder models with the motion tracking data. Articular cartilage T2* relaxation times were measured by quantitative MRI scans. Articular cartilage contact strain and T2* relaxation time were compared in the shoulders before and three months after the supraspinatus tendon resections.Results: Excellent accuracy and reproducibility were found in our in vivo contact strain measurements with less than 1% errors. Changes in articular cartilage contact strain exhibited similar patterns with the changes in the T2* relaxation time after resection surgeries. Regional changes in the articular cartilage T2* relaxation time exhibited positive correlations with regional contact strain variations three months after the supraspinatus resection surgeries.Conclusion: This is the first study to measure in vivo articular cartilage contact strains with high accuracy and reproducibility. Positive correlations between contact strain and T2* relaxation time suggest that the articular cartilage extracellular matrix may responds to mechanical changes in local areas.

show abstract

“…It was further supported by positive correlations between regional variations in articular cartilage contact strain and T2* relaxation time (Fig 7). These results are consistent with previous clinical studies which reported increased T2* relaxation time on the regions of increased articular cartilage contact loads [37][38][39]. Although those clinical measurements must be the result of longterm response to altered joint loading, our relatively short three-month study suggests that the changes in the articular cartilage extracellular matrix may be initiated at the early stage of load variations.…”

Section: Discussionsupporting

confidence: 92%

Alterations in articular cartilage T2 star relaxation time following mechanical disorders: in vivo canine supraspinatus tendon resection models

Lee¹,

Hong²,

Lim

³

et al. 2020

Preprint

View full text Add to dashboard Cite

Abstract Background: The role of altered joint mechanics on cartilage degeneration in in vivo models has not been studied successfully due to a lack of pre-injury information. We aimed 1) to develop an accurate in vivo canine model to measure the changes in joint loading and T2 star (T2*) relaxation time before and after unilateral supraspinatus tendon resections, and 2) to find the relationship between regional variations in articular cartilage loading patterns and T2* relaxation time distributions.Methods: Rigid markers were implanted in the scapula and humerus of tested dogs. The movement of the shoulder bones were measured by a motion tracking system during normal gaits. In vivo cartilage contact strain was measured by aligning 3D shoulder models with the motion tracking data. Articular cartilage T2* relaxation times were measured by quantitative MRI scans. Articular cartilage contact strain and T2* relaxation time were compared in the shoulders before and three months after the supraspinatus tendon resections.Results: Excellent accuracy and reproducibility were found in our in vivo contact strain measurements with less than 1% errors. Changes in articular cartilage contact strain exhibited similar patterns with the changes in the T2* relaxation time after resection surgeries. Regional changes in the articular cartilage T2* relaxation time exhibited positive correlations with regional contact strain variations three months after the supraspinatus resection surgeries.Conclusion: This is the first study to measure in vivo articular cartilage contact strains with high accuracy and reproducibility. Positive correlations between contact strain and T2* relaxation time suggest that the articular cartilage extracellular matrix may responds to mechanical changes in local areas.

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Quantitative T₂* relaxation time analysis of articular cartilage of the tibiotalar joint in professional football players and healthy volunteers at 3T MRI

Abstract: 1 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;47:372-379.

Cited by 15 publications

References 28 publications

Alterations in articular cartilage T2 star relaxation time following mechanical disorders: in vivo canine supraspinatus tendon resection models

Alterations in articular cartilage T2 star relaxation time following mechanical disorders: in vivo canine supraspinatus tendon resection models

Alterations in articular cartilage T2 star relaxation time following mechanical disorders: in vivo canine supraspinatus tendon resection models

Alterations in articular cartilage T2 star relaxation time following mechanical disorders: in vivo canine supraspinatus tendon resection models

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Quantitative T2* relaxation time analysis of articular cartilage of the tibiotalar joint in professional football players and healthy volunteers at 3T MRI

Abstract: 1 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;47:372-379.

Cited by 15 publications

References 28 publications

Alterations in articular cartilage T2 star relaxation time following mechanical disorders: in vivo canine supraspinatus tendon resection models

Alterations in articular cartilage T2 star relaxation time following mechanical disorders: in vivo canine supraspinatus tendon resection models

Alterations in articular cartilage T2 star relaxation time following mechanical disorders: in vivo canine supraspinatus tendon resection models

Alterations in articular cartilage T2 star relaxation time following mechanical disorders: in vivo canine supraspinatus tendon resection models

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Quantitative T₂* relaxation time analysis of articular cartilage of the tibiotalar joint in professional football players and healthy volunteers at 3T MRI