Alterations in articular cartilage T2 star relaxation time following mechanical disorders: in vivo canine supraspinatus tendon resection models

Lee, Dokwan; Hong, Ki-Taek; Lim, Tae Seong; Lee, Eugene; Lee, Ye Hyun; Park, Ji Soon; Kim, Woo; Oh, Joo Han; Choi, Jung Ah; Song, Yongnam

doi:10.21203/rs.3.rs-22995/v4

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…In the instance of T2 Ã relaxometry, our findings are consistent with Lee et al findings; in their study also they also found that larger T2 Ã values corresponded to increased cartilage degradation in a canine model. 26 However, in a research by Mankin et al, T2 Ã values declined as cartilage deterioration progressed. 27 Even though the cause of these findings is unknown, it may be possible due to signal averaging, in which the effects of cartilage matrix degradation that promote T2 Ã decay are counteracted by including fluid, such as an increase in cartilage water content or the inclusion of extracellular fluid in cartilage fissures, in the T2 Ã relaxation calculation.…”

Section: Discussionmentioning

confidence: 93%

Qualitative and Quantitative Evaluation of Morpho-Metabolic Changes in Bone Cartilage Complex of Knee Joint in Osteoarthritis Using Simultaneous 18F-NaF PET/MRI—A Pilot Study

Jena

Goyal

Rana

et al. 2023

Indian J Radiol Imaging

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Background Articular cartilage (AC) loss and deterioration, as well as bone remodeling, are all symptoms of osteoarthritis (OA). As a result, an ideal imaging technique for researching OA is required, which must be sensitive to both soft tissue and bone health. Objective The aim of this study was to assess the potential of simultaneous 18F sodium fluoride (18F-NaF) positron emission tomography/magnetic resonance imaging (PET/MRI) to identify as well as classify osseous metabolic abnormalities in knee OA and to see if degenerative changes in the cartilage and bone on MRI might be correlated with subchondral 18F-NaF uptake on PET. Methods Sixteen (32 knees) volunteers with no past history of knee injury, with or without pain, were enrolled for the research from January to July 2021. The images of both knees were taken utilizing an molecular magnetic resonance (mMR) body matrix coil on a simultaneous PET/MRI biograph mMR. The acquisition was conducted after 45 minutes of intravenous infusion of 18F-NaF 185–370 MBq (5–10 mCi) over one PET bed for 40 minutes, while MRI sequences were performed simultaneously. Results All pathologies showed significantly higher maximum standardized uptake value (SUVmax) than the background. Thirty-four subchondral magic spots were identified on 18F-NaF PET without any structural alteration on MRI. Bone marrow lesions (BMLs) and osteophytes with higher MRI osteoarthritis knee score (MOAKS) score showed higher 18F-NaF uptake (grade1˂grade2˂grade3). BMLs had corresponding AC degeneration. There was discordance between grade 1 osteophytes (86.6%), sclerosis (53.7%) and grade 1 BML in cruciate ligament insertion site (91.66%); they did not have high uptake of 18F-NaF. In case of cartilage, there was significant difference between AC grades and average subchondral SUVmax and T2* relaxometry (grade0˂grade1˂grade2˂grade3˂grade4). BMLs are much more metabolically active than other pathologies, while sclerosis is the least. We also found that the subchondral uptake was statistically increased in the areas of pathology: Conclusion 18F-NaF PET/MRI was able to detect knee abnormalities unseen on MRI alone and simultaneously assessed metabolic and structural markers of knee OA across multiple tissues in the joint. Thus, it is a promising tool for detection of early metabolic changes in OA.

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Section: Discussionmentioning

confidence: 93%

Qualitative and Quantitative Evaluation of Morpho-Metabolic Changes in Bone Cartilage Complex of Knee Joint in Osteoarthritis Using Simultaneous 18F-NaF PET/MRI—A Pilot Study

Jena

Goyal

Rana

et al. 2023

Indian J Radiol Imaging

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“…Considering the high variability and poor reliability of delineating the medial margin of the rotator cuff insertion based on CT images, 10,39 the MR images were used to reconstruct this soft tissue insertion. To combine the CT and MR images, the medial margin of the rotator cuff insertion segmented from the MR images was transferred to the CT-based coordinates based on the transformation matrix, which was achieved from the bestfit alignment 20 of the CT-based and MR-based humerus models in the Geomagic software (Geomagic) (Figure 2A). Image registration.…”

Section: Exercise Testingmentioning

confidence: 99%

Glenoid Track Width Is Smaller Under Dynamic Conditions: An In Vivo Dual-Fluoroscopy Imaging Study

Wang

et al. 2022

Am J Sports Med

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Background: The glenoid track concept has been widely used to assess the risk of instability due to bipolar bone loss. The glenoid track width was commonly used as 83% of the glenoid width to determine if a lesion was on-track or off-track. However, the value was obtained under static conditions, and it may not be able to reflect the actual mechanism of traumatic dislocation during motion. Purpose: To compare the glenoid track width under dynamic and static conditions using a dual-fluoroscopic imaging system. Study Design: Controlled laboratory study. Methods: In total, 40 shoulders of 20 healthy volunteers were examined for both dynamic and static tests within a dual-fluoroscopic imaging system at 5 different arm positions: 30°, 60°, 90°, 120°, and 150° of abduction, keeping the shoulder at 90° of external rotation. The participants performed a fast horizontal arm backswing for dynamic tests while keeping their arm in maximum horizontal extension for static tests. Computed tomography scans were used to create 3-dimensional models of the humerus and scapula for 2-dimensional to 3-dimensional image registration. Magnetic resonance imaging scans were obtained to delineate the medial margin of the rotator cuff insertion. The glenoid track width was measured as the distance from the anterior rim of the glenoid to the medial margin of the rotator cuff insertion and compared between static and dynamic conditions. Results: The mean glenoid track widths at 30°, 60°, 90°, 120°, and 150° of abduction were significantly smaller under dynamic conditions (88%, 81%, 72%, 69%, and 68% of the glenoid width) than those under static conditions (101%, 92%, 84%, 78%, and 77% of the glenoid width) (all P < .001). The glenoid track width significantly decreased with the increasing abduction angles in the range of 30° to 120° under static conditions (all P < .003) and 30° to 90° under dynamic conditions (all P < .001). Conclusion: A smaller dynamic-based value should be considered for the glenoid track width when distinguishing on-track/off-track lesions. Clinical evidence is needed to establish the superiority of the dynamic-based value over the static-based value as an indicator for augmentation procedures. Clinical Relevance: Some off-track lesions might be misclassified as on-track lesions when the original commonly used static-based value of 83% is used as the glenoid track width.

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“…1 Transection of the supraspinatus tendon can lead to increased adduction and lateral shoulder subluxation without substan-tial abduction, as well as changes in articular cartilage contact strain that are associated with corresponding changes in the T2 Ã relaxation time. 2 As dogs disproportionately transfer more body weight to the thoracic limb musculature, trauma to the supraspinatus is of interest, in that injury may be anticipated to cause substantial lameness.…”

Section: Introductionmentioning

confidence: 99%

Age and Sex Comparison of the Canine Supraspinatus Tendon Using Quantitative Magnetic Resonance Imaging T2 Mapping

Pownder

Neri

Hayashi

et al. 2022

Vet Comp Orthop Traumatol

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Objective The normal canine supraspinatus tendon has properties commonly attributed to damage such as core hyperintensity and increased width. Little is published regarding the normal tendon, including how senescent changes and sex differences may affect the appearance. Conventional magnetic resonance imaging (MRI) techniques provide subjective analysis of tendons based on observer assessment of signal intensity and appearance. Quantitative MRI (qMRI) techniques such as T2 mapping provide an objective comparison of collagen orientation with analysis of a decay constant, T2. This study investigates age and sex related changes in the canine supraspinatus tendon using the qMRI technique of T2 mapping. Methods In this study, 34 tendons of clinically sound male and female dogs (0.6–13 years) were imaged using qMRI T2 mapping techniques. Sagittal plane T2 maps of the supraspinatus tendon were depth-normalized, and profiles compared using two separate four-parameter logistic equations describing T2 mapping profiles as sigmoidal curves. Combined parameters evaluated included range of T2 values, curve steepness, vertical curve shift, lower bound of T2, upper bound of T2 and horizontal curve shift. Results A significant reduction in the most central portion of the supraspinatus tendon was found for every increased year in age (−1.56 ± 0.47 milliseconds [−2.56, −0.56, p = 0.004]). No significant difference in curve parameters was found between sexes. Conclusion The reduction in T2 with age suggests a senescent change may be anticipated with the canine supraspinatus tendon.

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Alterations in articular cartilage T2 star relaxation time following mechanical disorders: in vivo canine supraspinatus tendon resection models

Cited by 3 publications

References 4 publications

Qualitative and Quantitative Evaluation of Morpho-Metabolic Changes in Bone Cartilage Complex of Knee Joint in Osteoarthritis Using Simultaneous 18F-NaF PET/MRI—A Pilot Study

Qualitative and Quantitative Evaluation of Morpho-Metabolic Changes in Bone Cartilage Complex of Knee Joint in Osteoarthritis Using Simultaneous 18F-NaF PET/MRI—A Pilot Study

Glenoid Track Width Is Smaller Under Dynamic Conditions: An In Vivo Dual-Fluoroscopy Imaging Study

Age and Sex Comparison of the Canine Supraspinatus Tendon Using Quantitative Magnetic Resonance Imaging T2 Mapping

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