Genotoxicity of two new carbazole derivatives with antifungal activity

trans-Dichlorobis(XPhos)palladium(II) Precatalyst for Suzuki–Miyaura Cross-Coupling Reactions of Aryl/Vinyl Sulfonates/Halides: Scope, Mechanistic Study, and Synthetic Applications

“…Combining the effectiveness of dialkylbiarylphosphine ligands and the advantages of precatalysts, Buchwald et al have thus developed XPhos-based palladacycle complexes ( Scheme 1 ) for coupling challenging boronic acid partners in SMC and other cross-coupling reactions. 9 Despite their excellent catalytic activities, these palladacycle-based precatalysts suffer from some drawbacks, such as their high temperature of activation ( Pd G1 ) 9b and low stability ( Pd G2 ) 9c or the genotoxicity of the resultant carbazole by-product 10 ( Pd G2-G4 ) and more generally their 3–4 step synthesis even if they are now commercially available. Alternative precatalysts have thus been envisaged by combining XPhos and N -heterocyclic carbene or π-allyl ligands ( Scheme 1 ).…”

Antigenotoxic and antimutagenic effects of lignin derivative BP-C2 against dioxidine and cyclophosphamide in vivo in murine cells

“…A portion of the liver was removed, washed in the same buffer and minced to obtain a cell suspension. Cell suspensions were processed as described earlier [47] . Briefly, 60 μL of cell suspension was mixed with 240 μL of 1% low-melting agarose in phosphate buffer saline heated to 42 °C (microthermostat "Termit", Russia).…”

Antimicrobial Potential of Carbazole Derivatives

“…The strain TA1535 indicated optimistic response only at 0.4 μg/mL in the absence of S9. [58] In 2017, Chakraborty et al reported the preparation and antimicrobial activities of fluorocarabazole and their respective quinone derivatives (15a-c and 16a-c) as presented in Figure 10. using standard agar well diffusion method (NCCLS 2000).…”

“…Compounds 20a, 20b and 20c gave stronger antibacterial efficacies and broader bioactive spectrum . [58] N H…”