Anti-platelet effects of anti-glaucomatous eye drops: an in vitro study on human platelets

Moschos, Marilita M.; Moustafa, Giannis A.; Papakonstantinou, Vasiliki D.; Tsatsos, Michael; Laios, Konstantinos; Antonopoulou, Smaragdi

doi:10.2147/dddt.s131582

Cited by 5 publications

(3 citation statements)

References 32 publications

(45 reference statements)

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“…Maric et al ( 12 ) found higher MPV levels and nailfold capillary morphological vascular changes in patients with exfoliative glaucoma. Antiplatelet effect of antiglaucomatous eye drops was reported ( 13 ). In a word, altered platelet aggregability may trigger microthrombosis of the retinal capillaries and the short ciliary arteries, which result in vascular damage and generate defects in the microcirculation of the optic nerve head.…”

Section: Discussionmentioning

confidence: 99%

Platelet Parameters and Their Relationships With the Thickness of the Retinal Nerve Fiber Layer and Ganglion Cell Complex in Primary Open-Angle Glaucoma

Shao

et al. 2022

Front. Neurol.

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ObjectiveGlaucoma is a neurodegenerative disease of the visual system. Platelet parameters are correlated with visual field mean deviation (MD) in glaucoma, but there is a lack of relative data on their relationship with structural changes in the retina. This study aimed to explore the relationship between platelet parameters and retinal nerve fiber layer (RNEL), ganglion cell complex (GCC) thickness, and cup/disk area ratio, evaluated by optical coherence tomography (OCT) in primary open-angle glaucoma (POAG).MethodsA total of 118 consecutive patients with POAG and 120 age- and sex-matched control subjects were included in this retrospective study. Demographic data, platelet parameters in blood tests, visual field, and OCT results were evaluated. The RNFL was divided into the temporal, superior, nasal, and inferior quadrants. Based on the visual field MD, the patients were stratified into mild (MD ≤ 6.0 dB), moderate (6 dB < MD ≤ 12 dB), and severe (MD > 12.0 dB) subgroups.ResultsPatients with POAG had significantly lower platelet (PLT) levels and significantly higher platelet distribution width (PDW) and mean platelet volume (MPV) levels than controls. As the visual field MD increased, structural evaluation by OCT identified loss of disk rim area, average GCC thickness, and average RNFL thickness (all P < 0.001), as well as increased PDW (P < 0.001) and MPV (P = 0.004) levels in patients with POAG. The Spearman's rank correlation analysis showed that PDW levels were significantly correlated with OCT parameters such as RNFL thickness (r = −0.370, P < 0.001), GCC thickness (r = −0.294, P = 0.001), and cup/disk area ratio (r = 0.322, P < 0.001), as well as visual field MD (r = 0.607, P < 0.001) and mean sensitivity (MS) (r = −0.570, P < 0.001). Significantly correlations were also found between MPV and RNFL thickness (r = −0.321, P < 0.001), GCC thickness (r = −0.194, P = 0.041), and cup/disk area ratio (r = 0.237, P = 0.010). All the quadrants showed similar negative correlations between PDW, MPV, and RNFL thickness. The multiple linear regression analyses showed significant association between PDW and RNFL thickness (β = −0.331, P < 0.001), PDW and GCC thickness (β = −0.288, P = 0.002), MPV and RNFL thickness (β = −0.313, P = 0.001), and MPV and GCC thickness (β = −0.188, P = 0.048).ConclusionThis study found significantly negative association between PDW, MPV levels and RNFL, GCC thickness, as well as positive association between PDW, MPV levels, and cup/disk area ratio in patients with POAG, suggesting that platelet activation may contribute to glaucomatous optic neuropathy.

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Section: Discussionmentioning

confidence: 99%

Platelet Parameters and Their Relationships With the Thickness of the Retinal Nerve Fiber Layer and Ganglion Cell Complex in Primary Open-Angle Glaucoma

Shao

et al. 2022

Front. Neurol.

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“…It was found that application of synthetic Ab induces significant RGC apoptosis in vivo, while anti-Ab treatment was effective in the prevention of RGC apoptosis in glaucoma patients (17,(47)(48)(49)(50)(51). Additionally, some anti-glaucoma medicines have apparent anti-platelet effects, suggesting that platelets participate in glaucoma development (52).…”

Section: Ab Peptide Accumulation Is Associated With a Variety Of Diseasesmentioning

confidence: 99%

On the Role of Platelet-Generated Amyloid Beta Peptides in Certain Amyloidosis Health Complications

et al. 2020

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As do many other immunity-related blood cells, platelets release antimicrobial peptides that kill bacteria, fungi, and even certain viruses. Here we review the literature suggesting that there is a similarity between the antimicrobials released by other blood cells and the amyloid-related Aβ peptide released by platelets. Analyzing the literature, we also propose that platelet-generated Aβ amyloidosis may be more common than currently recognized. This systemic Aβ from a platelet source may participate in various forms of amyloidosis in pathologies ranging from brain cancer, glaucoma, skin Aβ accumulation, and preeclampsia to Alzheimer’s disease and late-stage Parkinson’s disease. We also discuss the advantages and disadvantages of specific animal models for studying platelet-related Aβ. This field is undergoing rapid change, as it evaluates competing ideas in the light of new experimental observations. We summarized both in order to clarify the role of platelet-generated Aβ peptides in amyloidosis-related health disorders, which may be helpful to researchers interested in this growing area of investigation.

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“…Ингибиторы карбоангидразы бринзоламид и дорзоламид и β-адреноблокаторы бетаксолол и тимолол оказывают антитромбоцитарный эффект и ингибируют агрегацию тромбоцитов, в отличие от α2-адреномиметиков (бримонидин), не обладающих таким действием [16]. Фармакологический эффект дорзоламида обратно пропорционален центральной толщине роговицы [17].…”

Section: патогенетические основы побочного действия активных веществ unclassified

The effect of the main active substances of antihypertensive eye drops on condition of the eyes of glaucoma patients

Онуфрийчук

Газизова

Куроедов

et al. 2020

Tihookeanskij medicinskij žurnal

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Today, glaucoma is considered to be the most common cause of irreversible blindness. The treatment of this disease is aimed at reducing intraocular tension in order to slow down the deterioration of visual functions and to maintain accept‑ able quality of life. Most ophthalmologists prefer local medicamentous therapy. Despite a significant expansion of the range of antihypertensive medicines, a significant increase in the hypotensive effect is not always achieved in each certain case, at the same time, at long-term (sometimes lifetime) treatment local and systemic adverse reactions arise and intensify. The findings of recent clinical trials presented in this overview demonstrate an adverse effect of active compounds, preservatives and ad‑ ditives of ophthalmic medicines not only on the eye surface but also on the structure of anterior and posterior eye segments. Taking into account possible side effects of each component of medicines used in glaucoma therapy, ophthalmologists will be able to reasonably approach the choice of optimal treatment regimens with the lowest risk for patients.

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Anti-platelet effects of anti-glaucomatous eye drops: an in vitro study on human platelets

Cited by 5 publications

References 32 publications

Platelet Parameters and Their Relationships With the Thickness of the Retinal Nerve Fiber Layer and Ganglion Cell Complex in Primary Open-Angle Glaucoma

Platelet Parameters and Their Relationships With the Thickness of the Retinal Nerve Fiber Layer and Ganglion Cell Complex in Primary Open-Angle Glaucoma

On the Role of Platelet-Generated Amyloid Beta Peptides in Certain Amyloidosis Health Complications

The effect of the main active substances of antihypertensive eye drops on condition of the eyes of glaucoma patients

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