The effect of the main active substances of antihypertensive eye drops on condition of the eyes of glaucoma patients

Онуфрийчук, О. Н.; Газизова, И. Р.; Куроедов, А. В.; Селезнев, А. В.

doi:10.34215/1609-1175-2020-3-5-10

Cited by 2 publications

(1 citation statement)

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“…Однако применение гипотензивных препаратов сопряжено с детергентным действием не только консервантов, но и самого активного вещества, а также вспомогательных веществ и буферов [52]. Но, тем не менее, большинство исследований переключения демонстрирует преимущества бесконсервантных препаратов.…”

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Prerequisites to Use Preservative-Free Drugs in Medication Therapy of Glaucoma

et al. 2021

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Purpose — to analyze the literature data on the benefits of preservative-free medication therapy for glaucoma.Materials and methods. 482 articles in the Pubmed database published from 1975 to 2020 were analyzed using the terms: “glaucoma”, “preservatives”, “preservative-free therapy”, “benzalkonium chloride”. The review includes 78 articles. Inclusion criteria: studies that examined the effect of local antihypertensive therapy on the condition of the ocular surface in comparison with preservative-free drugs.Discussion. BAC is the most common preservative used in ophthalmology, accounting for 70 % of eye drop formulations. But it has a pronounced toxic effect on the ocular surface, so other classes of preservatives have been developed. These include polyquaternium-1 detergent; oxidizing preservatives — stabilized oxychlorocomplex and sodium perborate; ionic buffer preservative. However, most of the publications are devoted to BAC, as it is considered the most toxic and, at the same time, the most commonly used preservative. There is a large number of switching studies from preservative therapy to preservative-free, in which almost all groups of drugs used for the treatment of glaucoma were studied, but the use of antihypertensive drugs is associated not only with the action of preservatives, but also with the active substance, excipients and buffers. However, most switching studies demonstrate the benefits of preservative-free drugs. Other studies compared preservative and preservative-free drugs with the same active ingredients, in which a comparable hypotensive effect and safety profile was revealed, which indicates that BAC is not required for adequate penetration of the active substance to the point of application. At the same time, statistically significant advantages in the tolerability of preservativefree therapy were also revealed.Conclusion. Glaucoma preservative therapy has a toxic effect on the ocular surface, which leads to a decrease in the quality of life and compliance. Switching to preservative-free drugs can help reduce iatrogenic complications during long-term treatment of patients with glaucoma

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Prerequisites to Use Preservative-Free Drugs in Medication Therapy of Glaucoma

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Fundamentals of a personalized approach at different stages of newly diagnosed glaucoma

Zubasheva,

Chernyakova,

Baryshnikova

et al. 2024

Rossijskij oftalʹmologičeskij žurnal

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The review is focused on the adherence of glaucoma patients to the immediate start of treatment after the condition has been diagnosed. A personalized strategy, which includes the assessment of the patient's clinical and socio-economic status and the use of medications with proven efficacy, contributes to the formation of long-term adherence to therapy. In particular, the strategy combines preventive and diagnostic measures depending on the patient’s individual characteristics and involves their direct participation. Over 250 risk factors are known to reduce a patient’s adherence to treatment, whereas insufficient adherence can itself be considered as a risk factor for glaucoma progression. The asymptomatic course of the disease or the lack of a noticeable effect of drops instilled often cause the regimen to be violated, whilst the long-term therapy requires determination and self-control of the patient. Combined measures to improve the adherence are based on the specific needs of the patients and are consistent with their lifestyle. As a rule, the patients need special instruction, good means of communication with the doctor, simplified treatment regimens, and an adequate interaction with the public health facilities. Importantly, the therapy start depends not only on the level of intraocular pressure, but also on the stage of the glaucomatous process at which it was first diagnosed.

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The effect of the main active substances of antihypertensive eye drops on condition of the eyes of glaucoma patients

Cited by 2 publications

References 48 publications

Prerequisites to Use Preservative-Free Drugs in Medication Therapy of Glaucoma

Prerequisites to Use Preservative-Free Drugs in Medication Therapy of Glaucoma

Fundamentals of a personalized approach at different stages of newly diagnosed glaucoma

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