Whole extracts of Radix Achyranthis Bidentatae and Radix Cyathulae promote angiogenesis in human umbilical vein endothelial cells in vitro and in zebrafish in vivo

Zhou, Xuelin; Siu, Wing Tai; Zhang, Cheng; Liu, Cheuk‐Lun; Cheng, Ling; Kwok, Hin‐Fai; Fung, Chak‐Hei; Tam, Jacqueline Chor‐Wing; Lau, Clara Bik‐San; Leung, Ping‐Chung; Hung, L.K.; Ko, Chun‐Hay

doi:10.3892/etm.2017.4053

Cited by 9 publications

(3 citation statements)

References 24 publications

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“…Angiogenesis is a physiological process that is responsible for the formation of new blood vessels from existing blood vessels. Endothelial cells participate in this process through various mechanisms such as proliferation, migration, and fusion (Polverini 2002; Zhou et al 2017). In addition to being an expected event in processes such as angiogenesis, growth and development, and wound healing, it can also be pathological in some cases.…”

Section: Discussionmentioning

confidence: 99%

Teratogenic and Neurotoxic Effects of n‐Butanol on Zebrafish Development

et al. 2021

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In recent years, n‐butanol, a type of alcohol, has been widely used from the chemical industry to the food industry. In this study, toxic effects of n‐butanol's different concentrations (10, 50, 250, 500, 750, 1,000, and 1,250 mg/L) in Zebrafish Danio rerio embryos and larvae were investigated. For this purpose, Zebrafish embryos were exposed to n‐butanol in acute semistatic applications. Teratogenic effects such as cardiac edema, scoliosis, lordosis, head development abnormality, yolk sac edema, and tail abnormality were determined at different time intervals (24, 48, 72, 96, and 120 h). Additionally, histopathological abnormalities such as vacuole formation in brain tissue and necrosis in liver tissue were observed at high doses (500, 750, and 1,000 mg/L) in all treatment groups at 96 h. It was determined that heart rate decreased at 48, 72, and 96 h due to an increase in concentration. In addition, alcohol‐induced eye size reduction (microphthalmia) and single eye formation (cyclopia) are also among the effects observed in our research findings. In conclusion, n‐butanol has been observed to cause intense neurotoxic, teratogenic, and cardiotoxic effects in Zebrafish embryos and larvae.

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Section: Discussionmentioning

confidence: 99%

Teratogenic and Neurotoxic Effects of n‐Butanol on Zebrafish Development

et al. 2021

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“…Tetrahydroprotoberberines, dehydrocorybulbine, and L-tetrahydropalmatine are active components that can be isolated from YHS; these have been demonstrated to exert analgesic and antinociceptive effects on chronic inflammatory and injury-induced neuropathic pain [47–50]. Niu Xi (NX) has been reported to induce angiogenesis and is used as treatment for bone injury [51]; it is a key component in both SJHXT and XFZYT and was commonly used as treatment for NONFH in our study. Moreover, NX is a key component of the Huogu II formula, which showed preventive and therapeutic effects in an experimental model of ONFH [52].…”

Section: Discussionmentioning

confidence: 99%

Association of Traditional Chinese Medicine Therapy with Risk of Total Hip Replacement in Patients with Nontraumatic Osteonecrosis of the Femoral Head: A Population-Based Cohort Study

Yeh

Chiang

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Background. Osteonecrosis of the femoral head (ONFH) contributes to 45% of total hip replacements (THRs) annually in Taiwan. Nontraumatic ONFH (NONFH) is multifactorial; no effective Western medicine is available to delay the disease process. This population-based cohort study investigated the association of traditional Chinese medicine (TCM) therapy with risk of THR in patients with NONFH. Methods. This retrospective study was conducted using claims data from all insured residents covered by the National Health Insurance from 2000 to 2010. We enrolled 1,680 newly diagnosed ONFH patients who had not undergone THR, before or within 6 months after diagnosis of ONFH; these patients did not exhibit hip fracture or dislocation before the endpoint. In total, 595 propensity score-matched pairs were selected from among 1,028 TCM users and 652 non-TCM users. The association between TCM use and risk of THR was analyzed using a Cox proportional hazard model. Kaplan-Meier and log rank tests were performed to plot the cumulative incidence of THR. Results. The mean follow-up periods were 5.00 years and 3.57 years for TCM and non-TCM cohorts, respectively. Compared to the non-TCM cohort, the TCM cohort had fewer patients undergoing THR surgery (25.4% vs. 18.2%, adjusted hazard ratio: 0.60, p<0.0001). The risk of reduction was noted in the group aged 30–59 years (adjusted hazard ratio: 0.56, p<0.0001), but there was no association with gender nor socioeconomic status. There was a significantly lower cumulative incidence of THR in TCM users (p<0.0001). Shu-Jing-Huo-Xue-Tang and Yan Hu Suo were the most frequently prescribed formula and single herb, respectively. Conclusions. NONFH patients using TCM had a lower risk of THR; the risk of reduction was noted in the group aged 30–59 years but was not associated with gender nor socioeconomic status. TCM might be useful in conservative treatment for NONFH.

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“…Radix Achyranthis Bidentatae (RAB), a kind of Chinese herbal medicine is known to regulate bone metabolism, promote bone formation and inhibit bone loss [ 15 ], which has a long history and a wide range of applications in Asia, particularly in China, Japan, and Korea for their effects on OP and bone fracture. Studies have shown that many ingredients of RAB have the effect of regulating glucose metabolism, Increasing blood flow, and anti-OP effects [ 16 – 18 ]. Inokosterone (IS), ecdysterone (ES), hyssop polysaccharide (HP), yssop saponin (YS) are the mainly active ingredients extracted from RAB by high performance liquid chromatography (HPLC).…”

Section: Introductionmentioning

confidence: 99%

Antiosteoporosis effect and possible mechanisms of the ingredients of Radix Achyranthis Bidentatae in animal models of osteoporosis: systematic review and meta-analysis of in vivo studies

et al. 2023

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Background The effect and mechanisms of the ingredients (IRAB) of Radix Achyranthis Bidentatae (RAB) on treating osteoporosis (OP) remains debated. We aimed to summary the evidence to evaluate the efficacy of IRAB for animal model OP and elucidate the potential mechanism of IRAB in the treatment of OP. Methods In this review and meta-analysis, we searched PubMed, EMBASE, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure, Wanfang, Chinese Biomedical Literature Database, as well as Chinese VIP databases for targeting articles published from inception to March 2023 in English or Chinese. All randomized controlled animal trials that assessed the efficacy and safety of IRAB for OP were included. We excluded trials according to exclusion criteria. The CAMARADES 10-item quality checklist was utilized to test the risk of potential bias for each including study and modifications were performed accordingly. The primary outcome measures were bone mineral density of the femoral neck (F-BMD), serum calcium (Ca), serum phosphorus (P), serum alkaline phosphatase (ALP), bone gla protein (BGP), bone maximum stress (M-STRESS). The secondary outcome measure was the antiosteoporosis mechanisms of IRAB. Results Data from nine articles were included in the systematic review and meta-analysis, which focused on 196 animals. Egger’s test revealed the presence of publication bias in various studies regarding the primary outcome. Administration of IRAB or RAB could significantly increases the F-BMD (SMD = 2.09; 95% CI = 1.29 to 2.89; P < 0.001, I2 = 76%), Ca (SMD = 0.86; 95% CI = 0.39to1.34; P = 0.07, I2 = 49%); P (SMD = 1.01; 95% CI = 0.45–4.57; P = 0.08, I2 = 50%), BGP (SMD = 2.13; 95% CI = 1.48 to 2.78; I2 = 46%, P = 0.10), while the ALP (SMD = − 0.85; 95% CI = − 1.38 to − 0.31; I2 = 46%, P = 0.10) was remarkably decreased in OP model animals. Moreover, the bone biomechanical indicator M-STRESS (SMD = 2.39; 95% CI = 1.74–3.04; I2 = 32%, P = 0.21) was significantly improved. Conclusion Collectively, the findings suggest that the RAB or IRAB could be an effective drug or an ingredient in diet for the clinical treatment of OP in future.

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Whole extracts of Radix Achyranthis Bidentatae and Radix Cyathulae promote angiogenesis in human umbilical vein endothelial cells in vitro and in zebrafish in vivo

Cited by 9 publications

References 24 publications

Teratogenic and Neurotoxic Effects of n‐Butanol on Zebrafish Development

Teratogenic and Neurotoxic Effects of n‐Butanol on Zebrafish Development

Association of Traditional Chinese Medicine Therapy with Risk of Total Hip Replacement in Patients with Nontraumatic Osteonecrosis of the Femoral Head: A Population-Based Cohort Study

Antiosteoporosis effect and possible mechanisms of the ingredients of Radix Achyranthis Bidentatae in animal models of osteoporosis: systematic review and meta-analysis of in vivo studies

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