Productos finales de glicación avanzada en la obesidad mórbida y tras la cirugía bariátrica: cuando la memoria glucémica empieza a fallar

Sánchez, Enric; Baena‐Fustegueras, Juan Antonio; Fuente, María Cruz de la; Gutiérrez-Carrasquilla, Liliana; Bueno, Marta; Ros, Susana; Lecube, Albert

doi:10.1016/j.endinu.2016.09.009

Cited by 13 publications

(3 citation statements)

References 22 publications

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“…Indeed, also the plasma concentration of the crosslink pentosidine was not affected by weight loss. Our finding is in accordance with a recent study in morbidly obese individuals where bariatric surgery did not change SAF in the 5 years follow-up period [29].…”

Section: Effect Of the Weight Loss Interventionsupporting

confidence: 94%

Diet-induced weight loss reduces postprandial dicarbonyl stress in abdominally obese men: Secondary analysis of a randomized controlled trial

et al. 2021

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Aims: Dicarbonyl compounds contribute to the formation of advanced glycation endproducts (AGEs) and the development of insulin resistance and vascular complications. Dicarbonyl stress may already be detrimental in obesity. We evaluated whether diet-induced weight loss can effectively reverse dicarbonyl stress in abdominally obese men. Materials and methods: Plasma samples were collected from lean (n ¼ 25) and abdominally obese men (n ¼ 52) in the fasting state, and during a mixed meal test (MMT). Abdominally obese men were randomized to 8 weeks of dietary weight loss or habitual diet, followed by a second MMT. The a-dicarbonyls methylglyoxal (MGO), glyoxal (GO) and 3-deoxyglucosone (3-DG) and AGEs were measured by UPLC-MS/ MS. Skin autofluorescence (SAF) was measured using the AGE reader. T-tests were used for the crosssectional analysis and ANCOVA to assess the treatment effect. Results: Postprandial glucose, MGO and 3-DG concentrations were higher in obese men as compared to lean men (p < 0.05 for all). Fasting dicarbonyls, AGEs, and SAF were not different between lean and obese men. After the weight loss intervention, fasting MGO levels tended to decrease by 25 nmol/L (95%-CI: -51-0.5; p ¼ 0.054). Postprandial dicarbonyls were decreased after weight loss as compared to the control group: iAUC of MGO decreased by 57% (5280 nmol/L•min; 95%-CI: 33e10526; p ¼ 0.049), of GO by 66% (11,329 nmol/L•min; 95%-CI: 495e22162; p ¼ 0.041), and of 3-DG by 45% (20,175 nmol/L•min; 95%-CI: 5351e35000; p ¼ 0.009). AGEs and SAF did not change significantly after weight loss. Conclusion: Abdominal obesity is characterized by increased postprandial dicarbonyl stress, which can be reduced by a weight loss intervention. Registered under ClinicalTrials.gov Identifier no. NCT01675401.

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Section: Effect Of the Weight Loss Interventionsupporting

confidence: 94%

Diet-induced weight loss reduces postprandial dicarbonyl stress in abdominally obese men: Secondary analysis of a randomized controlled trial

et al. 2021

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“…We assessed only selected biomarkers of glycoxidation and nitrosative/nitrative stress, so we cannot fully characterize the effect of bariatric surgery on redox homeostasis in morbidly obese patients. Furthermore, we are not able to determine the source of NO formation and we have not evaluated the expression of proinflammatory cytokines, which are inseparable from the oxidation and glycation of proteins [62]. Finally, we are not able to eliminate the influence of drugs and diet on the assessed redox biomarkers.…”

Section: Discussionmentioning

confidence: 98%

Bariatric Surgery Normalizes Protein Glycoxidation and Nitrosative Stress in Morbidly Obese Patients

et al. 2020

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The results of recent studies indicate the key role of nitrosative stress and protein oxidative damage in the development of morbid obesity. Nevertheless, the effect of bariatric surgery on protein oxidation/glycation and nitrosative/nitrative stress is not yet known. This is the first study evaluating protein glycoxidation and protein nitrosative damage in morbidly obese patients before and after (one, three, six and twelve months) laparoscopic sleeve gastrectomy. The study included 50 women with morbid obesity as well as 50 age- and gender-matched healthy controls. We demonstrated significant increases in serum myeloperoxidase, plasma glycooxidative products (dityrosine, kynurenine, N-formyl-kynurenine, amyloid, Amadori products, glycophore), protein oxidative damage (ischemia modified albumin) and nitrosative/nitrative stress (nitric oxide, peroxy-nitrite, S-nitrosothiols and nitro-tyrosine) in morbidly obese subjects as compared to lean controls, whereas plasma tryptophan and total thiols were statistically decreased. Bariatric surgery generally reduces the abnormalities in the glycoxidation of proteins and nitrosative/nitrative stress. Noteworthily, in the patients with metabolic syndrome (MS+), we showed no differences in most redox biomarkers, as compared to morbidly obese patients without MS (MS-). However, two markers: were able to differentiate MS+ and MS- with high specificity and sensitivity: peroxy-nitrite (>70%) and S-nitrosothiols (>60%). Further studies are required to confirm the diagnostic usefulness of such biomarkers.

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“…Dietary quality as shown by an increase in the Mediterranean Diet Score improved, but AGE intake was not calculated before or after the diet [ 30 ]. In contrast, Sánchez and coworkers found that AGEs measured using skin autofluorescence did not decrease following weight loss when measured five years after bariatric surgery [ 31 ]. However, the authors suggest that this result was not unexpected, as protein turnover is a major determinant of AGE accumulation in collagen and may be take up to 15 years [ 32 ], so the timeframe of the study was not sufficient to see a decrease.…”

Section: Discussionmentioning

confidence: 99%

Effects of Weight Loss on Advanced Glycation End Products in Subjects with and without Diabetes: A Preliminary Report

Deo

Keogh

Price

et al. 2017

IJERPH

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Advanced glycation end-products (AGEs) are formed endogenously as a normal ageing process and during food processing. High levels of AGEs have been implicated in the development of both macrovascular disease and microvascular disease. The purpose of this secondary analysis was to determine whether a major AGE species, Nε-carboxymethyllysine (CML), was reduced after weight loss. CML values decreased by 17% after weight loss. Participants with diabetes and pre-diabetes had a lower CML values at baseline and a smaller change in CML than overweight participants without diabetes. We conclude that, in addition to the known health benefits, weight loss may reduce AGEs. Randomized studies of the effect of weight loss on AGE in people with and without type 2 diabetes are needed to confirm these results.

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Productos finales de glicación avanzada en la obesidad mórbida y tras la cirugía bariátrica: cuando la memoria glucémica empieza a fallar

Cited by 13 publications

References 22 publications

Diet-induced weight loss reduces postprandial dicarbonyl stress in abdominally obese men: Secondary analysis of a randomized controlled trial

Diet-induced weight loss reduces postprandial dicarbonyl stress in abdominally obese men: Secondary analysis of a randomized controlled trial

Bariatric Surgery Normalizes Protein Glycoxidation and Nitrosative Stress in Morbidly Obese Patients

Effects of Weight Loss on Advanced Glycation End Products in Subjects with and without Diabetes: A Preliminary Report

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