Helicobacter pylori infection and serum leptin, obestatin, and ghrelin levels in Mexican schoolchildren

Abstract

BackgroundThere is little information about the possible role of Helicobacter pylori infection on appetite-regulating peptides in children. This study evaluated the association between H. pylori infection and serum levels of ghrelin, leptin, and obestatin in schoolchildren.MethodsOne hundred seventy-eight schoolchildren, students at boarding schools in Mexico City, participated. H. pylori infection status was determined every 6 months for 1 year by a breath test using C-urea; schoolchildren with consistently positive or negative results were selected to participate. Age, sex, and body mass index (BMI) were recorded. Serum concentrations of total ghrelin, leptin, and obestatin via specific enzyme-linked immunosorbent assays were determined.ResultsSchoolchildren with H. pylori infection had lower concentration of leptin, -0.54 pg/ml (95% CI: -0.98 to -0.09), compared to the schoolchildren without infection, after adjustment by age, gender, and BMI. And the children with the infection had a median of obestatin lower in 0.99 ng/ml (95% CI: -1.93 to -0.06) compared with the uninfected children after adjustment by BMI.ConclusionAssociation was found between H. pylori infection and decreased serum concentrations of leptin and obestatin. These results suggest that in schoolchildren, H. pylori infection affects the levels of hormones implicated in regulating appetite and energy homeostasis.

Helicobacter pylori infection in children

“…In this study, H. pylori ‐infected children had lower concentrations of leptin and obestatin than those without infection, after adjustment on age, gender, and BMI. These results suggest that H. pylori infection affects the levels of hormones implicated in regulating appetite and energy homeostasis …”

The association of garlic with Helicobacter pylori infection and gastric cancer risk: A systematic review and meta‐analysis

“…One of the five cross‐sectional studies yielded a significant result, and there is a possibility for reverse causality between garlic intake and H. pylori infection. On one hand, studies have found that H. pylori infection might affect the levels of hormones regulating appetite and, in particular, subsequently decrease individual appetite . On the other hand, chronic inflammation of the stomach due to H. pylori can likewise results in the loss of appetite .…”

Association between Helicobacter pylori Infection and Colorectal Adenomatous Polyps

“…First, Helicobacter pylori infection could upregulate the expression of matrix metalloproteinases [12], which may take part in not only colorectal carcinogenesis from adenomatous polyps but also colorectal tumor invasion and initiation of a metastatic cascade [13]. Second, Helicobacter pylori infection can lead to abnormal secretion of ghrelin secreted by the gastric mucosa [14], and ghrelin can prevent the occurrence of colorectal adenomatous polyps and colorectal cancer [15]. Third, Helicobacter pylori effects the inflammatory state of the intestine through the release of cytotoxins, lipopolysaccharide (LPS), and other toxic substances [16], which are involved in the formation of colorectal adenomatous polyps [17].…”