Nutritional Composition and Phytochemical, Antioxidative, and Antifungal Activities ofPergularia tomentosaL.

Abstract

Crude extracts from a medicinal Tunisian plant, Pergularia tomentosa L., were the investigated natural material. Butanolic extract of roots analyzed with IR spectra revealed the presence of hydroxyl, alcoholic, and carboxylic groups and sugars units. Analysis of some secondary metabolites, total phenolic, flavonoids, flavonols, and procyanidins, was performed using different solvents following the increased gradient of polarity. Fruits and leaves contained the highest amounts of all these compounds. Antioxidant properties were evaluated by the determination of free radical scavenging activity and the reducing power of methanolic extracts. Fruits and leaf extracts were the most powerful antioxidants for the two-assay in vitro system. Stems and fruits extracts exhibit an antifungal activity against Fusarium oxysporum f. sp. lycopersici which could become an alternative to synthetic fungicide to control Solanum species fungal diseases.

Phytochemical screening and HPTLC fingerprint analysis of Pergularia Tomentosa and Priploca Aphylla and evaluation their effects on Promastigotes of Leishmania major under laboratory conditions

“…Although there was no significant difference between the cytotoxicity of Pergularia tomentosa and Priploca aphylla extracts on Leishmania and Vero cell line, but it is clear that in each extract concentration, cytotoxicity effect of the extracts on Vero cell line is lower than toxicity on Leishmania promastigotes, this is promising to continue the study of these plants to find the effective metabolites on Leishmania and other trypanosomatid parasites. Our findings about the effectiveness of these plants extracts on Leishmania major are consistent with the experiences of the local traditional therapists and also are in accordance with the results of studies conducted by several researcher such as, Savita G, Imen L, Khalid A, Joseph A, Jamshed I, that have been reported the potent antimicrobial activity of Pergularia tomentosa and Priploca aphylla [17][18][19]33 . The local traditional therapists successfully use the diluted white latex of Pergularia tomentosa and decoction of the leaves and stems of Priploca aphylla to treat cutaneous form of leishmaniasis.…”

“…Imen L. and his colleagues in their study showed that the P. tomentosa stems and fruits aqueous extracts exhibit antifungal activity against Fusarium oxysporum f. sp. lycopersici which could become an alternative to synthetic fungicide drugs 17 . Also Results from Khalid A. and his colleagues study showed that the ethanolic extract of P. tomentosa caused a higher mortality of Aedes.…”

“…The syringe was mounted on a Linomat V applicator attached to CAMAG HPTLC system and was programmed through WIN CATS software. Staining was performed at 25±2 o C ascending development of the plate with elution distance of 80 mm (distance to the lower edge was 10 mm17,27 .…”

Oxidative Stress Modulation and ROS‐Mediated Toxicity in Cancer: A Review on In Vitro Models for Plant‐Derived Compounds

“…In addition, bioactive molecules extracted from MAPs have revealed anti-inflammatory properties through TNF- α inhibition and in vitro decrease of nitric oxide generation [ 13 ]. Natural antioxidants might be more beneficial than synthetic ones, with the latter causing potential health side effects during long intake periods [ 14 ].…”

Fraxinus: A Plant with Versatile Pharmacological and Biological Activities

“…Protective products originated from natural substances mainly from plants as alternative to synthetic fungicides is the spotlight issue nowadays [ 92 ]. Natural antimicrobial products are inexpensive and they have a potential for implementation in fungal pathogenic systems [ 93 ].…”