Rotavirus Vaccination and the Risk of Celiac Disease or Type 1 Diabetes in Finnish Children at Early Life

Vaarala, Outi; Jokinen, Jukka; Lahdenkari, Mika; Leino, Tuija

doi:10.1097/inf.0000000000001600

Cited by 52 publications

(50 citation statements)

References 8 publications

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“…134 Similarly, a comprehensive analysis of children at high risk of type 1 diabetes found no association with childhood vaccinations and islet autoimmunity, 135 consistent with previous studies. Rotavirus vaccination introduced in many countries in the 2000s, was not significantly associated with type 1 diabetes in children in Finland, 136 but a suggestive lower incidence was seen in vaccinees in Australia 137 and USA. 138 Follow-up of participants from a randomised trial of RotaTeq in Finland did not find any significant difference in incidence of type 1 diabetes after 12-14 years.…”

Section: Helminthsmentioning

confidence: 94%

Type 1 diabetes—early life origins and changing epidemiology

Norris

Johnson

Stene

2020

The Lancet Diabetes & Endocrinology

239

171

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Type 1 diabetes is a chronic, immune-mediated disease characterised by the destruction of insulinproducing cells. Standardised registry data show that type 1 diabetes incidence has increased 3-4% over the past three decades, supporting the role of environmental factors. Although several factors have been associated with type 1 diabetes, none of the associations are of a magnitude that could explain the rapid increase in incidence alone. Moreover, evidence of changing prevalence of these exposures over time is insufficient. Multiple factors could simultaneously explain the changing type 1 diabetes incidence, or the magnitude of observed associations could have been underestimated because of exposure measurement error, or the mismodelling of complex exposure-time-response relationships. The identification of environmental factors influencing the risk of type 1 diabetes and increased understanding of the cause at the individual level, regardless of the ability to explain the changing incidence at the population level, is important because of the implications for prevention.

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Section: Helminthsmentioning

confidence: 94%

Type 1 diabetes—early life origins and changing epidemiology

Norris

Johnson

Stene

2020

The Lancet Diabetes & Endocrinology

239

171

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“…Vaarala et al40 reported that RV vaccination did not alter the risk of celiac disease and type I diabetes. In contrast, the recent study by Kemppainen et al25 proposed a protective association between RV vaccine and the development of celiac disease, considering RV as an important environmental factor for triggering autoimmunity.…”

Section: The Lessons Learnt From Rv Vaccinationmentioning

confidence: 99%

Rotavirus infection beyond the gut

Gómez-Rial¹,

Sánchez-Batán²,

Rivero‐Calle³

et al. 2018

IDR

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The landscape of rotavirus (RV) infection has changed substantially in recent years. Autoimmune triggering has been added to clinical spectrum of this pathology, which is now known to be much broader than diarrhea. The impact of RV vaccines in these other conditions is becoming a growing field of research. The importance of host genetic background in RV susceptibility has been revealed, therefore increasing our understanding of vaccine effectiveness and giving some clues about the limited efficacy of RV vaccines in low-income settings. Also, interaction of RV with intestinal microbiota seems to play a key role in the process of infection vaccine effect. This article reviews current findings on the extraintestinal impact of RV infection and their widening clinical picture, and the recently described mechanisms of host susceptibility to infection and vaccine effectiveness. RV infection is a systemic disease with clinical and pathophysiological implications beyond the gut. We propose an “iceberg” model for this pathology with almost hidden clinical implications away from the gastrointestinal tract and eventually triggering the development of autoimmune diseases. Impact of current vaccines is being influenced by host genetics and gut microbiota interactions and these factors must be taken into account in the development of public health programs.

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“…They also indicated a 17% reduction in the risk of acute coronary syndromes in patients >65 years who received pneumococcal polysaccharide vaccine, but no effect was seen in younger patients Type 1 diabetes While direct cause and effect remain controversial, studies in the USA [62] and Australia [63] suggested a decline of 37 and 15%, respectively, in the risk of developing type 1 diabetes in rotavirus-vaccinated children in the period immediately after vaccination. A Finnish study [64] found a smaller, non-significant reduction…”

Section: Building a New Treatment Paradigm: P4 Medicinementioning

confidence: 92%

“…While supporting data are not conclusive, there are reasons to believe that "personalizing" vaccine recommendations may help improve compliance with universal vaccination recommendations. The first reason is our experience with existing public health campaigns, where a desire to protect/ improve personal health appears to be a driver of compliance with recommendations [21], e.g., cervical cancer screening (where, typically, participation in screening programs far exceeds the vaccination rate in adults [64] despite the fact that it requires more effort on the part of the patient). The second reason is the existing evidence that health-seeking behaviour is, in many cases, associated with improved vaccination coverage.…”

Section: Integrating Vaccination Into a P4 Medicine Strategymentioning

confidence: 99%

Precision Medicine and Vaccination of Older Adults: From Reactive to Proactive (A Mini-Review)

Doherty¹,

Pasquale²,

Michel³

et al. 2019

Gerontology

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Key Messages• As populations age, the total disease burden due to non-communicable or chronic conditions in older adults increases: infectious diseases are a significant and under-appreciated contributor to poor outcomes in this population. • Vaccination has been shown to dramatically improve outcomes in patients with chronic comorbidities but is almost always under-used in adults. • If vaccination programs for adults reached their full potential, the risk of hospitalization or death due to both infectious and non-infectious diseases could be effectively lowered. • A precision medicine approach, which integrates vaccination as part of a package of health interventions targeting an individual's needs, may offer a promising complementary approach to improving coverage and reducing the total burden of disease in addition to current public health interventions. AbstractAs populations age globally, the health of older adults is looming larger on the agendas of public health bodies.

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Rotavirus Vaccination and the Risk of Celiac Disease or Type 1 Diabetes in Finnish Children at Early Life

Abstract: Our results suggest that oral rotavirus vaccination is considered safe in the individuals at risk of CD and T1D.

Cited by 52 publications

References 8 publications

Type 1 diabetes—early life origins and changing epidemiology

Type 1 diabetes—early life origins and changing epidemiology

Rotavirus infection beyond the gut

Precision Medicine and Vaccination of Older Adults: From Reactive to Proactive (A Mini-Review)

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