Association between atopic dermatitis and contact sensitization: A systematic review and meta-analysis

Contact allergy in Danish children: Current trends

“…The relationship between atopic dermatitis and allergic contact dermatitis is controversial and continues to be debated. Authors of recent review articles have found no overall difference in the prevalence of contact sensitization between patients with atopic dermatitis and non‐atopics . In the present study, the overall sensitization prevalence was the same among children with atopic dermatitis as among children without atopic dermatitis, in agreement with recent similar studies .…”

Is a specific eyelid patch test series useful? Results of a French prospective study

“…However, no statistically significant association was found between the test results and atopic dermatitis status. This is in accordance with a recent meta‐analysis concerning the relationship between contact sensitization and atopic dermatitis …”

The role of skin barrier in occupational contact dermatitis

“…While Ross‐Hansen et al found no difference in the elicitation dose‐response relationship between FLG mutation and non‐mutation carriers in already nickel allergic individuals, the risk of nickel ACD is higher in FLG mutation carriers from large Danish and German general population cohorts . A recent systematic review and meta‐analysis reported no association of AD with contact sensitization to common allergens in patient studies, but a positive relationship in general population studies. The discrepancies in the various experimental, clinical and epidemiological studies have recently been discussed and argued that multiple allergen and host factors may affect the association between AD and contact sensitization including Th‐2 cytokine milieu in AD which might lower the risk of contact sensitization, difference in exposure pattern to allergens between AD patients and healthy individuals and a higher prevalence of false‐positive patch test reactions in AD, particularly in the case of metal allergens .…”

“…The role of AD and FLG mutations in ACD is less obvious, and the literature data are conflicting . Theoretically, reduced skin barrier in AD and presence of FLG mutations would increase the levels of allergens penetrating across the SC and hence the risk of ACD.…”