Dropwise additive manufacturing of pharmaceutical products for amorphous and self emulsifying drug delivery systems

Içten, Elçin; Purohit, Hitesh S.; Wallace, Chelsey; Giridhar, Arun; Taylor, Lynne S.; Nagy, Zoltán K.; Reklaitis, Gintaras V.

doi:10.1016/j.ijpharm.2017.04.003

Cited by 40 publications

(9 citation statements)

References 41 publications

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“…3D printing is becoming popular day by day. With its capability to print using a wide range of materials, 3D printing technology is propagating toward making the medicine of different shapes and sizes with ingredients according to the age group of the people (Içten et al , 2017). The first successful attempt in printing the medicine was Spritam (used for treating epilepsy), which was approved by Food and Drug Administration (FDA) in 2015 (Di prima et al , 2015).…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

On the adoption of additive manufacturing in healthcare: a literature review

Ramola

Yadav

Jain

2019

JMTM

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Purpose The purpose of this paper is to discuss different 3D printing techniques and also illustrate the issues related to 3D printing and cost-effectiveness in the near future. Design/methodology/approach A systematic literature review methodology is adopted for this review paper. 3D printing is in the initial phase of implementation in healthcare; therefore, a study of 70 research papers is done, which discusses the research trends of 3D printing in healthcare sector from 2007 to mid-2018. Findings Though additive manufacturing has a vast application, it has not been used to its full potential. Therefore, more research is required in that direction. It is revealed from the review that only a few researchers have explored issues related to cost, which can clearly show cost-effectiveness of adopting 3D printing. Originality/value This paper helps in understanding the different 3D printing techniques and their application in the healthcare. It also proposed some methods which can be applied in delivering customized pharmaceuticals to the customer and to improve surgery.

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Section: Discussion and Future Perspectivesmentioning

confidence: 99%

On the adoption of additive manufacturing in healthcare: a literature review

Ramola

Yadav

Jain

2019

JMTM

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“…The degree of cellulose substitution, molecular weight, presence and concentration of additives are parameters affecting the methyl cellulose gel-formation temperature and the characteristics of the resulting gel (Sarkar 1979). Besides, methyl cellulose is an emulsifying additive (Içten et al 2017), which is useful for drug delivery systems. Methyl cellulose is mostly used for biomedical applications such as tissue engineering, wound healing, and pharmaceutical formulations.…”

Section: Methyl Cellulosementioning

confidence: 99%

Cellulose and its derivatives: towards biomedical applications

et al. 2021

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Cellulose is the most abundant polysaccharide on Earth. It can be obtained from a vast number of sources, e.g. cell walls of wood and plants, some species of bacteria, and algae, as well as tunicates, which are the only known cellulose-containing animals. This inherent abundance naturally paves the way for discovering new applications for this versatile material. This review provides an extensive survey on cellulose and its derivatives, their structural and biochemical properties, with an overview of applications in tissue engineering, wound dressing, and drug delivery systems. Based on the available means of selecting the physical features, dimensions, and shapes, cellulose exists in the morphological forms of fiber, microfibril/nanofibril, and micro/nanocrystalline cellulose. These different cellulosic particle types arise due to the inherent diversity among the source of organic materials or due to the specific conditions of biosynthesis and processing that determine the consequent geometry and dimension of cellulosic particles. These different cellulosic particles, as building blocks, produce materials of different microstructures and properties, which are needed for numerous biomedical applications. Despite having great potential for applications in various fields, the extensive use of cellulose has been mainly limited to industrial use, with less early interest towards the biomedical field. Therefore, this review highlights recent developments in the preparation methods of cellulose and its derivatives that create novel properties benefiting appropriate biomedical applications.

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“…In addition to co-surfactant, the concentration of surfactants can be decreased, as it increases the loading capacity of the active pharmaceutical compound. Cosurfactants increase the interfacial fluidity and hence reduce the chances of variability and local irritation caused by surfactants also enhancing the process of dispersion in the medium [50]. Ethanol, propylene glycol, and other newer co-surfactants such as transcutol P and Glycofurol are a few of common excipients used as cosurfactants [51].…”

Section: Co-surfactantmentioning

confidence: 99%

Amelioration of lipophilic compounds in regards to bioavailability as self-emulsifying drug delivery system (SEDDS)

Baghel¹,

Roy²,

Verma

et al. 2020

Futur J Pharm Sci

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Background: High lipophilicity and poor aqueous solubility are the endemic problems of new drug molecules. Sixty to seventy percent of these drugs are unable to solubilize completely in aqueous media, or have very low permeability. This hampers their oral absorption and further leads to their poor bioavailability. Various researches are in progress to overcome these limitations. Novel technologies like nano-carrier systems have become popular for improving the solubility of drugs. Main body: Lipid-based formulations, among nano systems, are taking pace for the enhancement of solubility, oral absorption, and hence the bioavailability of drugs. Among the lipid formulations, self-emulsification systems are gaining popularity by offering various advantages to delivery systems. Self-emulsifying drug delivery systems (SEDDS) are isotropic blends of oil and surfactant/co-surfactants. These ingredients upon gentle agitation in aqueous media results in the formation of o/w emulsion. In spite of many works published in SEDDS, the major concerns of this article are to discuss the various approaches to formulate a good lipid-based carrier system for poorly aqueous soluble drugs, role of various polymers, and their categories used in the formulation along-with the modern technologies used for enhancing the stability of liquid SEDDS. This review majorly focuses upon the problems related to the poor aqueous solubility of the newer lipid molecules and the solutions to overcome their solubility and in addition bioavailability. Conclusion:As per the researches done in formulation and optimization of SEDDS for the enhancement of bioavailability of lipophilic molecules, it can be stated that the aqueous solubility as well as bioavailability can be increased by many folds compared to their marketed or other oral formulations.

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Dropwise additive manufacturing of pharmaceutical products for amorphous and self emulsifying drug delivery systems

Cited by 40 publications

References 41 publications

On the adoption of additive manufacturing in healthcare: a literature review

On the adoption of additive manufacturing in healthcare: a literature review

Cellulose and its derivatives: towards biomedical applications

Amelioration of lipophilic compounds in regards to bioavailability as self-emulsifying drug delivery system (SEDDS)

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