Cellulose and its derivatives: towards biomedical applications

Seddiqi, Hadi; Oliaei, Erfan; Honarkar, Hengameh; Jin, Jianfeng; Geonzon, Lester C.; Bacabac, Rommel G.; Klein‐Nulend, Jenneke

doi:10.1007/s10570-020-03674-w

Cited by 462 publications

(239 citation statements)

References 357 publications

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“…Similarly, amylopectin also has (1, 4) glycosidic bonds, but the structure is branched with several side chains of 24-30 glucose monomers, which are held together by (1, 6) glycosidic linkages [29,30]. Cellulose is a linear polysaccharide composed of more than a few hundred to several thousands of β (1→4) linked D-glucose units [31]. Cellulose is the most abundant biopolymer due to its proper-ties, which are essential structural components of marine animals, green plants, bacteria, and algae [32].…”

Section: Biopolymermentioning

confidence: 99%

Biopolymer and Synthetic Polymer-Based Nanocomposites in Wound Dressing Applications: A Review

et al. 2021

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Biopolymers are materials obtained from a natural origin, such as plants, animals, microorganisms, or other living beings; they are flexible, elastic, or fibrous materials. Polysaccharides and proteins are some of the natural polymers that are widely used in wound dressing applications. In this review paper, we will provide an overview of biopolymers and synthetic polymer-based nanocomposites, which have promising applications in the biomedical research field, such as wound dressings, wound healing, tissue engineering, drug delivery, and medical implants. Since these polymers have intrinsic biocompatibility, low immunogenicity, non-toxicity, and biodegradable properties, they can be used for various clinical applications. The significant advancements in materials research, drug development, nanotechnology, and biotechnology have laid the foundation for changing the biopolymeric structural and functional properties. The properties of biopolymer and synthetic polymers were modified by blending them with nanoparticles, so that these materials can be used as a wound dressing application. Recent wound care issues, such as tissue repairs, scarless healing, and lost tissue integrity, can be treated with blended polymers. Currently, researchers are focusing on metal/metal oxide nanomaterials such as zinc oxide (ZnO), cerium oxide (CeO2), silver (Ag), titanium oxide (TiO2), iron oxide (Fe2O3), and other materials (graphene and carbon nanotubes (CNT)). These materials have good antimicrobial properties, as well as action as antibacterial agents. Due to the highly antimicrobial properties of the metal/metal oxide materials, they can be used for wound dressing applications.

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Section: Biopolymermentioning

confidence: 99%

Biopolymer and Synthetic Polymer-Based Nanocomposites in Wound Dressing Applications: A Review

et al. 2021

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“…Cellulose has attracted considerable interest related to biomaterial production due to its suitable mechanical and physical properties. Moreover, it is characterized by biodegradability and low production cost, making it widely used for the fabrication of dressing materials [45].…”

Section: Current Concepts In Wound Dressingsmentioning

confidence: 99%

Modifications of Wound Dressings with Bioactive Agents to Achieve Improved Pro-Healing Properties

Vivcharenko

Przekora

2021

Applied Sciences

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The great variety of wounds and the lack of an effective universal treatment method has resulted in high demand for modern treatment strategies. Traditional approaches are often ineffective on a variety of chronic wounds, such as venous ulcers or the diabetic foot ulcer. There is strong evidence that naturally derived bioactive compounds have pro-healing properties, raising a great interest in their potential use for wound healing. Plant-derived compounds, such as curcumin and essential oils, are widely used to modify materials applied as wound dressings. Moreover, dressing materials are more often enriched with vitamins (e.g., L-ascorbic acid, tocopherol) and drugs (e.g., antibiotics, inhibitors of proteases) to improve the skin healing rate. Biomaterials loaded with the above-mentioned molecules show better biocompatibility and are basically characterized by better biological properties, ensuring faster tissue repair process. The main emphasis of the presented review is put on the novel findings concerning modern pro-healing wound dressings that have contributed to the development of regenerative medicine. The article briefly describes the synthesis and modifications of biomaterials with bioactive compounds (including curcumin, essential oils, vitamins) to improve their pro-healing properties. The paper also summarizes biological effects of the novel wound dressings on the enhancement of skin regeneration. The current review was prepared based on the scientific contributions in the PubMed database (supported with Google Scholar searching) over the past 5 years using relevant keywords. Scientific reports on the modification of biomaterials using curcumin, vitamins, and essential oils were mainly considered.

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“…BC allows the transfer of medicine into the wound while serving as an efficient physical barrier against external infection. BC has been also used for numerous biomedical and tissue-engineering applications, as well as production of high-quality papers, diaphragms for audio speakers, and polymer composites [6][7][8][9][10][11].…”

Section: Bacterial Cellulose: What We Know So Farmentioning

confidence: 99%

Systematic Understanding of Recent Developments in Bacterial Cellulose Biosynthesis at Genetic, Bioprocess and Product Levels

Buldum

Mantalaris

2021

IJMS

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Engineering biological processes has become a standard approach to produce various commercially valuable chemicals, therapeutics, and biomaterials. Among these products, bacterial cellulose represents major advances to biomedical and healthcare applications. In comparison to properties of plant cellulose, bacterial cellulose (BC) shows distinctive characteristics such as a high purity, high water retention, and biocompatibility. However, low product yield and extensive cultivation times have been the main challenges in the large-scale production of BC. For decades, studies focused on optimization of cellulose production through modification of culturing strategies and conditions. With an increasing demand for BC, researchers are now exploring to improve BC production and functionality at different categories: genetic, bioprocess, and product levels as well as model driven approaches targeting each of these categories. This comprehensive review discusses the progress in BC platforms categorizing the most recent advancements under different research focuses and provides systematic understanding of the progress in BC biosynthesis. The aim of this review is to present the potential of ‘modern genetic engineering tools’ and ‘model-driven approaches’ on improving the yield of BC, altering the properties, and adding new functionality. We also provide insights for the future perspectives and potential approaches to promote BC use in biomedical applications.

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Cellulose and its derivatives: towards biomedical applications

Cited by 462 publications

References 357 publications

Biopolymer and Synthetic Polymer-Based Nanocomposites in Wound Dressing Applications: A Review

Biopolymer and Synthetic Polymer-Based Nanocomposites in Wound Dressing Applications: A Review

Modifications of Wound Dressings with Bioactive Agents to Achieve Improved Pro-Healing Properties

Systematic Understanding of Recent Developments in Bacterial Cellulose Biosynthesis at Genetic, Bioprocess and Product Levels

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