Short- and long-term effects of zinc treatment on lacrimal gland histopathology and
            tear functions tests in radioiodine-administered rats

Örnek, Firdevs; Acar, Damla Ergintürk; Acar, Uğur; Özdemir, Özdemir; Atilgan, Hasan Ikbal; Yumuşak, Nihat; Özgermen, Başak Boztok

doi:10.5935/0004-2749.20170010

Cited by 4 publications

(2 citation statements)

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“…Согласно распространенному мнению, ионизирующее излучение приводит к развитию реакций, вследствие которых образуются свободные радикалы, которые взаимодействуют с внутриклеточными мембранами, нарушая их целостность [ 23 ][ 24 ]. Полученные в ходе патоморфологических исследований на животной модели результаты показали, что непосредственно после воздействия 131I в ткани слезной железы возникает выраженный воспалительный процесс, который сопровождается метаплазией эпителиальных клеток, а также апоптотическими изменениями на фоне индуцированного радиационным воздействием фиброза [ 8 ][ 22 ][ 25 ]. Проведенные исследования не выявили корреляций между частотой и/или степенью поражения слезной железы и введенной активностью 131I [ 9 ][ 11 ].…”

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“…К настоящему моменту не разработаны какиелибо схемы профилак тики осложнений радиойодтерапии со стороны слезной железы, которые имели бы доказанную клиническую эф фективность. Ведутся экспериментальные исследования, в рамках которых изучают возможности антиоксидант ной защиты медикаментозными средствамиантиокси дантами: витаминами D и E, коэнзимом Q10, препаратами на основе цинка, ликопина и ресвератрола [8,22,[25][26][27]. Нами не найдено клинических рекомендаций по специ фическому лечению данного осложнения.…”

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The lacrimal apparatus as an organ at risk during radionuclide therapy

Sheremeta,

Trukhin,

Yartsev

et al. 2024

Probl Endokrinol (Mosk)

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Within the framework of the article, the authors analyzed the available information about the damage to the lacrimal apparatus during radionuclide therapy. In focus of article lesions of the lacrimal production system, the main and accessory lacrimal glands, as well as lacrimal drainage are considered. It was found that damage to the lacrimal apparatus is characteristic of 131I therapy for thyroid cancer, as well as for radioligand therapy using anti-PSMA antibodies labeled with 177Lu and 225Ac. 177Lu-PSMA and 225Ac-PSMA may damage the lacrimal gland with the formation of a clinically pronounced "dry eye syndrome". The pathogenesis of such lesions is associated with the accumulation of a radioisotope in the tissues of the lacrimal apparatus, while during therapy with 131I, accumulation is realized due to the expression of the sodium-iodine symporter in the nasolacrimal duct, and during therapy with 177Lu-PSMA and 225Ac-PSMA, the radiobiological effect is realized in connection with the expression PSMA by lacrimal tissue. An analysis of the available sources showed that to date there are no results of systematic studies on the problem, there is a lack of knowledge regarding the individual risks of developing these complications, methods for their prevention that have proven effectiveness have not been developed, and the treatment methods used, having relatively low efficiency, are not specialized. The authors concluded that the strengthening of interdisciplinary interaction, as well as the organization verification methodology and correct studies, can contribute to solving problems related to the study of the complications under consideration.

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The lacrimal apparatus as an organ at risk during radionuclide therapy

Sheremeta,

Trukhin,

Yartsev

et al. 2024

Probl Endokrinol (Mosk)

View full text Add to dashboard Cite

show abstract

Update on lacrimal apparatus dysfunction associated with differentiated thyroid cancer after I-131 therapy

Liang,

Wu,

Liu

et al. 2024

Int Ophthalmol

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Secondary Acquired Nasolacrimal Duct Obstruction as a Specific Complication of Treatment With Radioactive Iodine (Morphological Study)

Федоров

Atkova

Yartsev

2020

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: To conduct a morphological study of structural changes in the nasolacrimal duct in secondary acquired nasolacrimal duct obstruction (SALDO) as a result of treatment with radioiodine. Methods: Twenty patients (20 cases) were involved: 10 cases with secondary acquired nasolacrimal duct obstruction at Hasner’s valve level due to the treatment with radioiodine (group 1) and 10 cases with primary acquired nasolacrimal duct obstruction (group 2). During surgery, a biopsy of nasolacrimal duct tissue from Hasner’s valve area was taken. A morphological study was performed using semi-fine sections technique. Results: Patients of group 1 showed the following: desquamation of columnar epithelium, pinpoint ulceration of nasolacrimal duct wall, collapse of a significant part of the capillary bed, and absence of blood cells in their lumen. State of secretory cells of mucous glands varied from necrobiotic to the different stages of dystrophic, decreased lumens of acini with abundant microvesicles in cell cytoplasm were revealed. A specific sign noted in patients of group 2 was mixed inflammatory infiltration of the mucosa of the nasolacrimal duct. The picture corresponds to the exacerbation of a chronic inflammatory process. Conclusions: Changes revealed in patients of group 1 include desquamation of nasolacrimal duct epithelium, mucous gland lesion, and moderate fibrosis that indicate a probable primary character of the lesion. In patients of group 2, fibrotic changes were more significant and were due to a chronic inflammatory process. Thus, secondary acquired nasolacrimal duct obstruction after treatment with radioactive iodine has a specific pathogenesis and should be classified as a separate nosological form.

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Short- and long-term effects of zinc treatment on lacrimal gland histopathology and tear functions tests in radioiodine-administered rats

Abstract: Zinc treatment seems to be protective against RAI-induced lacrimal gland damage of rats, particularly in the acute period.

Cited by 4 publications

References 0 publications

The lacrimal apparatus as an organ at risk during radionuclide therapy

The lacrimal apparatus as an organ at risk during radionuclide therapy

Update on lacrimal apparatus dysfunction associated with differentiated thyroid cancer after I-131 therapy

Secondary Acquired Nasolacrimal Duct Obstruction as a Specific Complication of Treatment With Radioactive Iodine (Morphological Study)

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