One‐step synthesis of nitrogen, boron co‐doped fluorescent carbon nanoparticles for glucose detection

Liang, Meijuan; Ren, Yi; Zhang, Haijuan; Ma, Yi; Niu, Xiaoying; Chen, Xingguo

doi:10.1002/bio.3287

Cited by 14 publications

(5 citation statements)

References 48 publications

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“…It is speculated that covalent combination of glucose and boric acid groups was formed on the surface of BN‐CDs. Electrostatic repulsion between the particles has a significant effect on the performance for the detection of glucose according to other report [40] . Moreover, we also conducted TEM to confirm the morphology.…”

Section: Resultsmentioning

confidence: 55%

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One‐Step Hydrothermal Synthesis of Boric Acid‐Functionalized Carbon Dots and their Applications in Glucose Sensing

et al. 2022

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In this work, a straightforward one-step hydrothermal method was efficiently applied to prepare boronic acid-functionalized N-doped carbon dots (BN-CDs) using 3-aminobenzeneboronic acid and ascorbic acid as the starting materials. The BN-CDs exhibited a size distribution ranging from 1.5 nm to 4.0 nm, demonstrated good fluorescence stability and a high fluorescence quantum yield of 26.03 %. Glucose could accumulate on the surface of BN-CDs by covalently binding boric acid groups to glucose cis-glycol, thereby leading to the selective fluorescence quenching performance. A sensitive sensing platform for glucose detection was established in the linear range of 8-940 μmol/L with the detection limit (LOD) of 2.4 μmol/L. Satisfactory results were obtained in three kinds of sample analysis. It is worth mentioning that the incubation time of the proposed sensing platform is much shorter than that of most reported elsewhere. The BN-CDs based fluorescence detection method demonstrates good feasibility in practical applications.

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Section: Resultsmentioning

confidence: 55%

“…Electrostatic repulsion between the particles has a significant effect on the performance for the detection of glucose according to other report. [40] Moreover, we also conducted TEM to confirm the morphology. The initial BN-CDs nanoparticles were monodispersed with relatively uniform sizes (Figure 1a).…”

Section: Interaction Between the Bn-cds And Glucosementioning

confidence: 99%

One‐Step Hydrothermal Synthesis of Boric Acid‐Functionalized Carbon Dots and their Applications in Glucose Sensing

et al. 2022

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“…Colorimetric analysis is a method to determine the content of a substance to-be-measured by the color of the solution that features good stability, low cost, and implementation simplicity, making it widely applied to clinical diagnosis and detection, including in glucose analysis [3,[6][7][8]. However, current liquid colorimetry primarily requires lab-based infrastructure, and its utility greatly increases the use of point-of-use deployment.…”

Section: Introductionmentioning

confidence: 99%

Label-Free Colorimetric Detection of Urine Glucose Based on Color Fading Using Smartphone Ambient-Light Sensor

Wang

Guo

et al. 2020

Chemosensors

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In this work, a label-free colorimetric assay was developed for the determination of urine glucose using smartphone ambient-light sensor (ALS). Using horseradish peroxidase—hydrogen peroxide—3,3′,5,5′-tetramethylbenzidine (HRP-H2O2-TMB) colored system, quantitative H2O2 was added to samples to-be-determined for deepest color. The presence of glucose oxidase in urine led to the formation of H2O2 and the reduction of TMBred. As a result of this, the color of the urine faded and the solution changed from deep blue to light blue. We measured the illuminance of the transmitted light by a smartphone ambient light sensor, and thereby color changes were used to calculate the content of urine glucose. After method validation, this colorimetric assay was practically applied for the determination of urine samples from diabetic patients. Good linearity was obtained in the range of 0.039–10.000 mg/mL (R2 = 0.998), and a limit of detection was 0.005 mg/mL. Our method was had high accuracy, sensitivity, simplicity, rapidity, and visualization, providing a new sensor to be potentially applicable for point-of-care detection of urine glucose.

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“…In urinary sensors that use this technique, the glucose concentration is measured by detecting the change in fluorescence of the fluorophores [ 90 ]. Recently, Liang et al synthesized boron-doped carbon nanoparticles (NB-CNPs) with pH-sensitive fluorescent properties using a one-step solid-phase approach [ 91 ]. Here, a boronic acid-triggered specific reaction was utilized for the detection of glucose with an excitation wavelength of 370 nm within the range of 0–900 μM.…”

Section: Recent Developments In Various Biological Fluid-based Glucos...mentioning

confidence: 99%

Recent Advancement in Biofluid-Based Glucose Sensors Using Invasive, Minimally Invasive, and Non-Invasive Technologies: A Review

Reddy

Agarwal

et al. 2022

Nanomaterials

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Biosensors have potentially revolutionized the biomedical field. Their portability, cost-effectiveness, and ease of operation have made the market for these biosensors to grow rapidly. Diabetes mellitus is the condition of having high glucose content in the body, and it has become one of the very common conditions that is leading to deaths worldwide. Although it still has no cure or prevention, if monitored and treated with appropriate medication, the complications can be hindered and mitigated. Glucose content in the body can be detected using various biological fluids, namely blood, sweat, urine, interstitial fluids, tears, breath, and saliva. In the past decade, there has been an influx of potential biosensor technologies for continuous glucose level estimation. This literature review provides a comprehensive update on the recent advances in the field of biofluid-based sensors for glucose level detection in terms of methods, methodology and materials used.

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One‐step synthesis of nitrogen, boron co‐doped fluorescent carbon nanoparticles for glucose detection

Cited by 14 publications

References 48 publications

One‐Step Hydrothermal Synthesis of Boric Acid‐Functionalized Carbon Dots and their Applications in Glucose Sensing

One‐Step Hydrothermal Synthesis of Boric Acid‐Functionalized Carbon Dots and their Applications in Glucose Sensing

Label-Free Colorimetric Detection of Urine Glucose Based on Color Fading Using Smartphone Ambient-Light Sensor

Recent Advancement in Biofluid-Based Glucose Sensors Using Invasive, Minimally Invasive, and Non-Invasive Technologies: A Review

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