Fast and Selective Plasmonic Serotonin Detection with Aptamer-Gold Nanoparticle Conjugates

Chávez, Jorge L.; Hagen, Joshua A.; Kelley‐Loughnane, Nancy

doi:10.3390/s17040681

Cited by 51 publications

(27 citation statements)

References 32 publications

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“…This strategy yields a linear sensor response in the physiologically relevant serotonin concentration range of 750 nM–2.5 μ M 23 . Sensing tests done in serotonin-spiked fetal bovine serum (FBS) noted that the presence of proteins with the fetal bovine serum interfered with AuNP-aptamer serotonin response 23 . Thus, samples were first filtered through amicon filters before AuNP-aptamer based sensing.…”

Section: Synthetic Probesmentioning

confidence: 99%

Review Article: Tools and trends for probing brain neurochemistry

Beyene

Yang

Landry

2019

Journal of Vacuum Science &Amp; Technology A: Vacuum, Surfaces, and Films

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The brain is composed of complex neuronal networks that interact on spatial and temporal scales that span several orders of magnitude. Uncovering how this circuitry gives rise to multifaceted phenomena such as perception, memory, and behavior remains one of the grand challenges in science today. A wide range of investigative methods have been developed to delve deeper into the inner workings of the brain, spanning the realms of molecular biology, genetics, chemistry, optics, and engineering, thereby forming a nexus of discovery that has accelerated our understanding of the brain. Whereas neuronal electrical excitability is a hallmark property of neurons, chemical signaling between neurons—mediated by hundreds of neurotransmitters, neuromodulators, hormones, and other signaling molecules—is equally important, but far more elusive in its regulation of brain function for motor control, learning, and behavior. To date, the brain's neurochemical state has been interrogated using classical tools borrowed from analytical chemistry, such as liquid chromatography and amperometry, and more recently, newly developed fluorescent sensors. Here, the authors review advances in the development of functional fluorescent probes that are beginning to expand their understanding of the neurochemical basis of brain function alongside device-based analytical tools that have already made extensive contributions to the field. The emphasis herein is on the paradigms of probe and device development, which follow certain design principles unique to the interrogation of brain chemistry.

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Section: Synthetic Probesmentioning

confidence: 99%

Review Article: Tools and trends for probing brain neurochemistry

Beyene

Yang

Landry

2019

Journal of Vacuum Science &Amp; Technology A: Vacuum, Surfaces, and Films

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“…The majority of them have been obtained by modifying carbon electrode surfaces with a dispersion of CNTs in polymers or solvents, thus, increasing the sensitivity of the analysis by orders of magnitude with respect to the bare electrode surface. Numerous CNT-based sensors are reported in literature for neurotransmitter detection [37,38,39,40,41,42,43,44,45].…”

Section: Electrochemical Sensorsmentioning

confidence: 99%

Latest Trends in Electrochemical Sensors for Neurotransmitters: A Review

Tavakolian-Ardakani

Hosu

Cristea

et al. 2019

Sensors

109

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Neurotransmitters are endogenous chemical messengers which play an important role in many of the brain functions, abnormal levels being correlated with physical, psychotic and neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's disease. Therefore, their sensitive and robust detection is of great clinical significance. Electrochemical methods have been intensively used in the last decades for neurotransmitter detection, outclassing more complicated analytical techniques such as conventional spectrophotometry, chromatography, fluorescence, flow injection, and capillary electrophoresis. In this manuscript, the most successful and promising electrochemical enzyme-free and enzymatic sensors for neurotransmitter detection are reviewed. Focusing on the activity of worldwide researchers mainly during the last ten years (2010–2019), without pretending to be exhaustive, we present an overview of the progress made in sensing strategies during this time. Particular emphasis is placed on nanostructured-based sensors, which show a substantial improvement of the analytical performances. This review also examines the progress made in biosensors for neurotransmitter measurements in vitro, in vivo and ex vivo.

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“…Additionally, aptamers were also raised against the biogenic monoamines norepinephrine [ 93 ], acetylcholine [ 94 ], and serotonin (developed by Base Pair Biotechnologies, Inc., Pearland, TX, USA) [ 95 ].…”

Section: Aptamers For the Treatment And Diagnostics Of Neurologicamentioning

confidence: 99%

Nucleic Acid Aptamers: Emerging Applications in Medical Imaging, Nanotechnology, Neurosciences, and Drug Delivery

Röthlisberger

Gasse

Hollenstein

2017

IJMS

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Recent progresses in organic chemistry and molecular biology have allowed the emergence of numerous new applications of nucleic acids that markedly deviate from their natural functions. Particularly, DNA and RNA molecules—coined aptamers—can be brought to bind to specific targets with high affinity and selectivity. While aptamers are mainly applied as biosensors, diagnostic agents, tools in proteomics and biotechnology, and as targeted therapeutics, these chemical antibodies slowly begin to be used in other fields. Herein, we review recent progress on the use of aptamers in the construction of smart DNA origami objects and MRI and PET imaging agents. We also describe advances in the use of aptamers in the field of neurosciences (with a particular emphasis on the treatment of neurodegenerative diseases) and as drug delivery systems. Lastly, the use of chemical modifications, modified nucleoside triphosphate particularly, to enhance the binding and stability of aptamers is highlighted.

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Fast and Selective Plasmonic Serotonin Detection with Aptamer-Gold Nanoparticle Conjugates

Cited by 51 publications

References 32 publications

Review Article: Tools and trends for probing brain neurochemistry

Review Article: Tools and trends for probing brain neurochemistry

Latest Trends in Electrochemical Sensors for Neurotransmitters: A Review

Nucleic Acid Aptamers: Emerging Applications in Medical Imaging, Nanotechnology, Neurosciences, and Drug Delivery

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