Public health relevance of non-tuberculous mycobacteria among AFB positive sputa

Desikan, Prabha; Tiwari, Karuna; Panwalkar, Nikita; Khaliq, Saima; Chourey, Manju; Varathe, Reeta; Mirza, Shaina Beg; Sharma, Arun; Anand, Sridhar; Pandey, Manoj K.

doi:10.18683/germs.2017.1103

Cited by 16 publications

(12 citation statements)

References 16 publications

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“…3 The estimated incidence of NTM from different geographical locations in India is 3.4% to 24.7%. [1][2][3][4][5][6][7][8][9][10] The defined risk populations expected to harbour NTM are immune-compromised patients including patients with HIV infection and diabetes mellitus, pre-existing lung cavitation, old age, recent surgery or penetrating injury. [7][8] The disease spectrum of NTM is divided into chronic pulmonary infections, superficial lymphadenitis, skin and skeletal infections, and disseminated disease.…”

Section: Discussionmentioning

confidence: 99%

“…12,13 The cumulative outcome of NTM infections has been considered as good with appropriate therapy and surgical intervention whenever required. 2 A study from Southern India on surgical site infection with NTM in 24 patients showed a favourable outcome in 22 cases after appropriate antibiotics and debridement. 10 Similarly our patients with post-surgical infection had a good outcome without relapse at around 1 year.…”

Section: Discussionmentioning

confidence: 99%

“…NTM is an emerging infectious disease in India and across the world [1][2][3][4][5][6][7][8][9][10] which is attributed to better diagnostic tools, especially DNA sequencing. 7 NTM infection mimics tuberculosis, therefore necessitating culture and molecular methods for species identification.…”

Section: Introductionmentioning

confidence: 99%

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Non-tuberculous mycobacterium affecting adults in Eastern India: Case series from a resource limited tertiary care setting

Pandey¹,

Ghosh²,

Halder³

et al. 2019

Sri Lankan J Infec Dis

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Non-tuberculous mycobacterium affecting adults in Eastern India: Case series from a resource limited tertiary care setting

Pandey¹,

Ghosh²,

Halder³

et al. 2019

Sri Lankan J Infec Dis

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“…En países en vías de desarrollo, se presume que la mayoría de síntomas pulmonares que aparenten ser causados por micobacterias, son causados por M. tuberculosis. Esto se debe a la falta de herramientas diagnósticas en áreas de limitado recursos y la naturaleza endémica del patógeno (7,8) . Esto causa que muchas veces se realice un mal diagnóstico de la enfermedad, asumiéndose que se trata de M. tuberculosis cuando en realidad se trata de otro tipo de micobacteria.…”

Section: Discussionunclassified

Confección por Mycobacterium fortuitum y Mycobacterium tuberculosis en abscesos esplénicos en un paciente con VIH

Soto-Arquiñigo

García-Pareja

Gotuzzo-Herencia

et al. 2017

Rev Peru Med Exp Salud Publica

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Citar como: Citar como: Soto-Arquíñigo L, García-Pareja M, Gotuzzo-Herencia E, Legua-Leiva P, Sánchez-Herrera M. Confección por Mycobacterium fortuitum y Mycobacterium tuberculosis en abscesos esplénicos en un paciente con VIH. RESUMENLos pacientes con VIH son susceptibles a la infección por micobacterias. En el caso de las micobacterias de crecimiento rápido, grupo al que pertenece el Mycobacterium fortuitum (M. fortuitum), se han descrito infecciones en la piel, pulmones, ganglios linfáticos y enfermedad diseminada. Presentamos el caso de un paciente varón de 43 años, con diagnóstico previo de VIH en tratamiento antirretroviral, que acude por fiebre, astenia, pérdida de peso y diarrea crónica. Se realiza tomografía abdominal y se evidencia hepatoesplenomegalia con lesiones nodulares en el bazo. El cultivo esplénico, finalmente, fue positivo para M. fortuitum, con PCR positivo a Mycobacterium tuberculosis. Los protocolos actuales de tratamiento para este tipo de infecciones se basan en la susceptibilidad mostrada en los cultivos realizados. En lo que respecta a coinfecciones entre M. fortuitum y Mycobacterium tuberculosis, en pacientes VIH positivos, la información es aun menor. Palabras clave: Mycobacterium fortuitum, Mycobacterium tuberculosis; VIH; absceso (Fuente: DeCS BIREME). CO-INFECTION BY Mycobacterium fortuitum AND Mycobacterium tuberculosis IN SPLENIC ABSCESSES IN A PATIENT WITH HIV ABSTRACTPatients with HIV are susceptible to mycobacterium infection. In the case of fast-growing mycobacteria, the group to which Mycobacterium fortuitum (M. fortuitum) belongs, infections have been described in the skin, lungs, lymph nodes and disseminated disease. We present the case of a 43-year-old male patient with pre-diagnosis of HIV in antiretroviral therapy, which comes as a fever, asthenia, weight loss and chronic diarrhea. Abdominal tomography is performed and hepatosplenomegaly is evidenced with nodular lesions in the spleen. The splenic culture was finally positive for M. Fortuitum, with positive PCR to Mycobacterium tuberculosis. The current treatment protocols for this type of infection are based on the susceptibility shown in the cultures performed. With regard to coinfections between M. Fortuitum and Mycobacterium tuberculosis, in HIV positive patients, there are even less information.

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“…However, drinking untreated water and living in close contact with cattle or other domestic animals may lead of infection in human [66]. In USA, NTM diseases are more associated with densely populated areas, suggesting the infective source as urban municipal water supply [67], while Japan suggesting the soil as the source for more patients who were farmers and gardeners [68]. Furthermore, characteristic gradient clustering of the ratios of M. avium and M. intracellulare has been observed in Japan, suggesting that environmental factors strongly affect the epidemiology of NTMPD [69].…”

Section: Host-pathogen Interactionsmentioning

confidence: 99%

Overview of Non Tuberculosis Mycobacterial Lung Diseases

Diseases¹

2018

Mycobacterium - Research and Development

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Nontuberculosis mycobacteria (NTM) are ubiquitous in nature and opportunistically infect different animals, including humans. Currently, NTM is emerging as an important cause of pulmonary infection among both immunocompromised and immunocompetent persons worldwide. The clinical relevance of pulmonary NTM varies among species while showing geographical heterogeneity in distribution as well as pathogenicity. The outcome of the respiratory NTM disease is a consequence of a complex interplay between microbial factors and host susceptibility. Furthermore, HIV infection, cystic fibrosis, cancer, underlying chronic lung disease and history of tuberculosis (TB) may be associated as risk factors for active nontuberculosis pulmonary diseases (NTMPD). The diagnosis of NTMPD requires the presence of symptoms, radiographic evidences, microscopic observations and definitive laboratory diagnostics. Lung infections resulted from a clinically significant NTM species should be treated with appropriate antimicrobial regimen. M. leprae and M. lepraemurium are uncultivable and require the intracellular milieu for survival and propagation [4]. The obligatory causative agents of the genus Mycobacterium, responsible for TB are classified into Mycobacterium tuberculosis complex (MTC). It comprises M. tuberculosis, M.bovis, M. africanum, M. microti [5], M. canettii [6], M. caprae [7], M. pinnipedii [8], M. mungi [9], M. orygis [10] and M. suricattae [11] species. M. tuberculosis, M. africanum, M. canettii and M. orygis cause TB primarily in human [4, 10], whereas M. bovis [12], M. microti [13], M. caprae [7] M. pinnipedii [8], M. mungi [9] and M. suricattae [11] infect cattle, domestic animals, goats, seals, mongooses and meerkats, respectively, and animal tuberculosis can also be zoonotic [14, 15]. However, geographical variation of the MTC species distribution has been identified. As an example, M. africanum is a common cause of human pulmonary TB (39%) as much as M. tuberculosis (55%) in West Africa [16]. In Ghana, 3% of pulmonary TB cases are represented by M. bovis, while 20% are M. africanum and 73% are M. tuberculosis [17].Other medically important mycobacteria such as M. avium, M. intracellulare complex, M. kansasii, M. marinum, M. fortuitum, M. chelonae complex, M. abscessus and M. scrofulaceum are known as nontuberculosis mycobacteria (NTM) species or atypical mycobacteria or mycobacteria other than tuberculosis (MOTT). They are responsible for diseases including lymphadenitis in children, chronic pulmonary diseases, skin and soft-tissue diseases and infections of the skeletal system [18]. NTM are ubiquitous in nature and are widely distributed in water, soil and animals. Among prevailing NTM species, only a few species have a clinical impact on humans as opportunistic pathogens [19]. M. avium complex (MAC), M. abscessus, M. kansasii, M. fortuitum, M. chelonae, M. szulgai, M. triviale and M. scrofulaceum are common NTM species that cause pulmonary diseases in human [20]. Additionally, M. riyadhense was recently proposed as a cau...

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Public health relevance of non-tuberculous mycobacteria among AFB positive sputa

Cited by 16 publications

References 16 publications

Non-tuberculous mycobacterium affecting adults in Eastern India: Case series from a resource limited tertiary care setting

Non-tuberculous mycobacterium affecting adults in Eastern India: Case series from a resource limited tertiary care setting

Confección por Mycobacterium fortuitum y Mycobacterium tuberculosis en abscesos esplénicos en un paciente con VIH

Overview of Non Tuberculosis Mycobacterial Lung Diseases

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