Very Low Calorie Diets for Weight Loss in Obese Older Adults—A Randomized Trial

Haywood, Cilla; Prendergast, Luke A.; Purcell, Katrina; Fevre, Lauren Le; Lim, Wen Kwang; Galea, Mary P.; Proietto, Joseph

doi:10.1093/gerona/glx012

Cited by 37 publications

(41 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, it is important to note that these studies focus on either a restriction of all macronutrients, or a restriction of protein. The impact of weight loss achieved using a VLED on offspring health remains to be determined, but may not be similarly detrimental given that protein and micronutrient intake is maintained …”

Section: Evidence Gapsmentioning

confidence: 98%

Preconception management of women with obesity: A systematic review

et al. 2018

Self Cite

View full text Add to dashboard Cite

The prevalence of women of child-bearing age with obesity continues to rise at an alarming rate. This has significant implications for both the short-term and longterm health of mother and offspring. Given the paucity of evidence-based literature in this field, the preconception management of women with obesity is highly variable both between institutions and around the world. This systematic review aims to evaluate studies that inform us about the role of preconception weight loss in the fertility and pregnancy outcomes of women with obesity. Current therapeutic interventions are discussed, with a specific focus on the suitability of weight loss interventions for women with obesity planning pregnancy. There are significant knowledge gaps in the current literature; these are discussed and areas for future research are explored.

show abstract

Section: Evidence Gapsmentioning

confidence: 98%

Preconception management of women with obesity: A systematic review

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…The adverse effects of study interventions have been published . Briefly, despite halving insulin at baseline, two participants in Ex/VLCD had hypoglycaemia (BSLs 2.9 and 3.2 mmol/L).…”

Section: Resultsmentioning

confidence: 99%

“…The study was registered with the Australian and New Zealand Clinical Trials Registry (ACTRN12611000408987), and approved by the Austin Health Research Ethics Committee. Details regarding the recruitment, participants, monitoring and interventions in this study have been published previously elsewhere . Briefly, volunteers were eligible for the study if they were 65 years or over, community dwelling, and had a body mass index (BMI) ≥35 kg/m 2 .…”

Section: Methodsmentioning

confidence: 99%

“…The adverse effects of study interventions have been published. 9 Briefly, despite halving insulin at baseline, two participants in Ex/VLCD had hypoglycaemia (BSLs 2.9 and 3.2 mmol/L). Both resolved with ingestion of carbohydrates and no events occurred after further reduction of insulin dose.…”

Section: Adverse Effectsmentioning

confidence: 98%

“…Details regarding the recruitment, participants, monitoring and interventions in this study have been published previously elsewhere. 9 Briefly, volunteers were eligible for the study if they were 65 years or over, community dwelling, and had a body mass index (BMI) ≥35 kg/m 2 . A baseline visit was undertaken, where blood pressure was taken, and blood drawn for lipids, glucose and inflammatory markers.…”

Section: Study Oversightmentioning

confidence: 99%

See 2 more Smart Citations

Obesity in older adults: Effect of degree of weight loss on cardiovascular markers and medications

et al. 2019

Self Cite

View full text Add to dashboard Cite

Summary Obesity worsens the age‐related tendency towards cardiovascular disease and diabetes. Older adults are vulnerable to medication adverse effects. Intentional weight loss in older adults with obesity has been shown to improve cardiovascular and glycaemic markers. The effect of rapid weight loss induced by very‐low‐calorie diets (VLCDs) on these markers has not been evaluated in this group. In this 12‐week study, participants were randomized to one of healthy eating, hypocaloric diet or VLCD, all combined with three times weekly exercise (Ex/HE, Ex/Diet, Ex/VLCD, respectively). The effects of these interventions on weight, blood pressure, lipids, glucose and HbA1c, inflammatory markers and cardiovascular and diabetes medication changes were measured. Weight loss was 3.7%, 5.1% and 11.1% in Ex/HE, Ex/Diet and Ex/VLCD, respectively. There were significant improvements in HbA1c in all groups, but by the greatest degree in Ex/VLCD (0.18 ± 0.07%, 0.18 ± 0.06% and 0.59 ± 0.13%, respectively). Similar patterns were seen in total cholesterol (0.13 ± 0.15, 0.21 ± 0.11 and 0.53 ± 0.13 mmol/L, respectively, P = .047), triglycerides (0.35 ± 0.13, 0.20 ± 0.10 and 0.51 ± 0.09 mmol/L, respectively, P = .011) and systolic blood pressure (9 ± 2, 2 ± 3 and 14 ± 3 mmHg respectively, P = .025). There were no between‐group differences in fasting glucose, high‐density lipoprotein (HDL) cholesterol, LDL‐C and inflammatory markers. Reductions in anti‐hypertensive or diabetes medication were made in 4/29, 7/36 and 16/37 participants in Ex/HE, Ex/Diet and Ex/VLCD, respectively (P = .017). Significant weight loss achieved with a VLCD gave rise to improvements in multiple cardiovascular risk markers, despite reduction in medication. Weight loss is an under‐utilized method of cardiovascular risk management in this group.

show abstract

Impact of preconception weight loss on fasting glucose and pregnancy outcomes in women with obesity: A randomized trial

Price

Sumithran

Nankervis

et al. 2021

Obesity

Self Cite

View full text Add to dashboard Cite

The strong and continuous association between increasing BMI and adverse pregnancy outcomes has been well documented (1,2). It is also widely appreciated that the early metabolic environment of the offspring influences the susceptibility to metabolic disease later in life (3-5). Given that maternal obesity is independently associated with offspring adiposity (3,6), addressing obesity in women who are planning pregnancy is of critical importance.

show abstract

Very Low Calorie Diets for Weight Loss in Obese Older Adults—A Randomized Trial

Abstract: VLCDs have potential in the treatment of obesity in older persons; of particular benefit is improvement in nutritional status. The gait speed improvement observed in men warrants further investigation.

Cited by 37 publications

References 35 publications

Preconception management of women with obesity: A systematic review

Preconception management of women with obesity: A systematic review

Obesity in older adults: Effect of degree of weight loss on cardiovascular markers and medications

Impact of preconception weight loss on fasting glucose and pregnancy outcomes in women with obesity: A randomized trial

Contact Info

Product

Resources

About