Environmental and genetic determinants of two vitamin D metabolites in healthy Australian children

Bima, Abdulhadi; Pezic, Angela; Cameron, Fergus; Rodda, Christine; Mei, Ingrid van der; Chiaroni-Clarke, Rachel; Dwyer, Terence; Kemp, Andrew; Qu, Jun; Ellis, Justine A.; Ponsonby, Anne–Louise

doi:10.1515/jpem-2016-0088

Cited by 4 publications

(6 citation statements)

References 42 publications

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“…Components of the participant questionnaire regarding past sun exposure and skin reaction to sun were used to analyze the relationship between past sun exposure and JIA. These instruments have demonstrated validity and reliability in both adults and children, where they show strong correlation with objective measures of sun exposure and circulating vitamin D . Maternal sun exposure at 12 weeks of pregnancy was also recorded because we have previously related this to autoimmune disease .…”

Section: Methodsmentioning

confidence: 99%

“…Previously, we constructed two vitamin D genetic allele scores . The “Synscore” included two SNPs at genes involved in vitamin D synthesis ( CYP2R1 rs10741657, DHCR7 rs12785878), and the “Metscore” included two SNPs involved in vitamin D metabolism ( CYP24A1 rs6013897, GC rs2282679).…”

Section: Methodsmentioning

confidence: 99%

“…The relationship between sun exposure and circulating vitamin D is influenced by ambient UVR levels (determined by latitude, altitude, season and time of day), time in the sun and sun protection factors . In a recent study of healthy children in Melbourne, Australia, we reported that environmental factors (such as UVR exposure 6 weeks prior to interview) and phenotypic factors (such as skin color) explained 28% and 21% of the variance in circulating 25(OH)D 3 , respectively . Therefore, sun exposure can be used as a measure of child circulating 25(OH)D 3 in our setting.…”

Section: Introductionmentioning

confidence: 99%

“…To understand the relationship between sun exposure and JIA risk, we used validated questionnaire instruments to retrospectively collect information about sun exposure and associated factors across the life‐course in children with and without JIA born in Victoria, Australia. We compared reported predisease UVR exposure between cases and controls both during specific age periods (including mother's exposure during pregnancy) and cumulatively.…”

Section: Introductionmentioning

confidence: 99%

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Association of Increased Sun Exposure Over the Life‐course with a Reduced Risk of Juvenile Idiopathic Arthritis

Chiaroni-Clarke

Munro

Pezic

et al. 2018

Photochem & Photobiology

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Cutaneous sun exposure is an important determinant of circulating vitamin D. Both sun exposure and vitamin D have been inversely associated with risk of autoimmune disease. In juvenile idiopathic arthritis (JIA), low circulating vitamin D appears common, but disease‐related behavioral changes may have influenced sun exposure. We therefore aimed to determine whether predisease sun exposure is associated with JIA. Using validated questionnaires, we retrospectively measured sun exposure for 202 Caucasian JIA case–control pairs born in Victoria Australia, matched for birth year and time of recruitment. Measures included maternal sun exposure at 12 weeks of pregnancy and child sun exposure across the life‐course prediagnosis. We converted exposure to UVR dose and looked for case–control differences using logistic regression, adjusting for potential confounders. Higher cumulative prediagnosis UVR exposure was associated with reduced risk of JIA, with a clear dose–response relationship (trend P = 0.04). UVR exposure at 12 weeks of pregnancy was similarly inversely associated with JIA (trend P = 0.011). Associations were robust to sensitivity analyses for prediagnosis behavioral changes, disease duration and knowledge of the hypothesis. Our data indicate that lower UVR exposure may increase JIA risk. This may be through decreased circulating vitamin D, but prospective studies are required to confirm this.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of Increased Sun Exposure Over the Life‐course with a Reduced Risk of Juvenile Idiopathic Arthritis

Chiaroni-Clarke

Munro

Pezic

et al. 2018

Photochem & Photobiology

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“…A significant correlation between the variations in the VDR gene and a high risk of a decrease in circulating active form of vitamin D (1.5-3.7 times) was demonstrated [27]. Therefore, the mechanism underlying the correlation between vitamin D deficiency and menstrual dysfunction should be considered unspecified.…”

Section: The Role Of Vitamin D In the Development Of Menstrual Functionmentioning

confidence: 99%

Pathogenetic role of vitamin D deficiency in the development of menstrual dysfunction in pubertal girls: a literature review

Bashmakova

Lisovskaya

Vlasova

2017

Gynecological Endocrinology

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In the literature review, 50 scientific sources surrounding the problem of vitamin D deficiency, 80% of which amounted to the issuance of the last 5 years, have been analyzed. Despite the impact of vitamin D deficiency on the health of children and adolescents has been studied for a long time, the information on the role of vitamin D in the formation of menstrual function in pubertal girls is scant and ambiguous. Among the hypotheses of menstrual dysfunction with vitamin D deficiency, neurohumoral regulation of the hypothalamic-pituitary-ovarian system is considered to be essential due to the localization of vitamin D receptors (VDR), unlike other vitamins, in the nuclei of various tissues and organs. However, in the last 10 years, data on the role of genetic polymorphism of the VDR gene in the pathogenesis of various manifestations of menstrual dysfunction have been accumulated. Some studies indicated a beneficial effect of cholecalciferol on such menstrual dysfunctions as oligomenorrhea and dysmenorrhea. Regarding numerous data on the role of vitamin D, both traditional and recently published, there is a strong correlation between vitamin D deficiency and other various factors, determining a wide range of polymorphic clinical manifestations where menstrual dysfunction is essential in girls at the age of puberty. ARTICLE HISTORY

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Increased innate immune responses in adolescents with obesity and its relation to subclinical cardiovascular measures: An exploratory study

Bekkering,

Saner,

Novakovic

et al. 2024

iScience

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Environmental and genetic determinants of two vitamin D metabolites in healthy Australian children

Abstract: Environmental factors and genetic factors contributed to both vitamin D metabolite concentrations. The intriguing finding that the higher ambient UVR contributed to higher 1,25(OH)2D3 after accounting for 25(OH)D3 concentrations requires further evaluation.

Cited by 4 publications

References 42 publications

Association of Increased Sun Exposure Over the Life‐course with a Reduced Risk of Juvenile Idiopathic Arthritis

Association of Increased Sun Exposure Over the Life‐course with a Reduced Risk of Juvenile Idiopathic Arthritis

Pathogenetic role of vitamin D deficiency in the development of menstrual dysfunction in pubertal girls: a literature review

Increased innate immune responses in adolescents with obesity and its relation to subclinical cardiovascular measures: An exploratory study

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