Influence of low-level laser therapy on the healing of human bone maxillofacial defects: A systematic review

Santinoni, Carolina dos Santos; Oliveira, Hiskell Francine Fernandes e; Batista, Victor Eduardo de Souza; Lemos, Caa; Verri, Fellippo Ramos

doi:10.1016/j.jphotobiol.2017.03.004

Cited by 67 publications

(45 citation statements)

References 51 publications

(158 reference statements)

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“…This systematic review was conducted in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist, as well as previously published systematic reviews [43,44].…”

Section: Methodsmentioning

confidence: 99%

Photobiomodulation Therapy (PBMT) Applied in Bone Reconstructive Surgery Using Bovine Bone Grafts: A Systematic Review

et al. 2019

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The use of low-level laser therapy (LLLT) with biomodulatory effects on biological tissues, currently called photobiomodulation therapy (PBMT), assists in healing and reduces inflammation. The application of biomaterials has emerged in bone reconstructive surgery, especially the use of bovine bone due to its biocompatibility. Due to the many benefits related to the use of PBMT and bovine bones, the aim of this research was to review the literature to verify the relationship between PBMT and the application of bovine bone in bone reconstruction surgeries. We chose the PubMed/MEDLINE, Web of Science, and Scopus databases for the search by matching the keywords: “Bovine bone AND low-level laser therapy”, “Bovine bone AND photobiomodulation therapy”, “Xenograft AND low-level laser therapy”, and “Xenograft AND photobiomodulation therapy”. The initial search of the three databases retrieved 240 articles, 18 of which met all inclusion criteria. In the studies concerning animals (17 in total), there was evidence of PBMT assisting in biomaterial-related conduction, formation of new bone, bone healing, immunomarker expression, increasing collagen fibers, and local inflammation reduction. However, the results disagreed with regard to the resorption of biomaterial particles. The only human study showed that PBMT with bovine bone was effective for periodontal regeneration. It was concluded that PBMT assists the process in bone reconstruction when associated with bovine bone, despite divergences between applied protocols.

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Section: Methodsmentioning

confidence: 99%

Photobiomodulation Therapy (PBMT) Applied in Bone Reconstructive Surgery Using Bovine Bone Grafts: A Systematic Review

et al. 2019

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“…Research in vitro has demonstrated that laser irradiation (LI) promotes cell migration and proliferation [14,15], mitochondrial respiration [16,17,18], protein synthesis [14,19] and bone formation [20]. Dental pulp stem cells (DPSCs) have a mesenchymal stem cell (MSC) phenotype, and the potential to differentiate into multiple cell types, including odontoblasts, osteoblasts, chondrocytes, cardiomyocytes, hepatocytes, neuron, liver cells, and pancreatic islet β cells.…”

Section: Introductionmentioning

confidence: 99%

Effects of Er:YAG and Diode Laser Irradiation on Dental Pulp Cells and Tissues

Yamakawa

Niwa

Karakida

et al. 2018

IJMS

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Vital pulp therapy (VPT) is to preserve the nerve and maintain healthy dental pulp tissue. Laser irradiation (LI) is beneficial for VPT. Understanding how LI affects dental pulp cells and tissues is necessary to elucidate the mechanism of reparative dentin and dentin regeneration. Here, we show how Er:YAG-LI and diode-LI modulated cell proliferation, apoptosis, gene expression, protease activation, and mineralization induction in dental pulp cells and tissues using cell culture, immunohistochemical, genetic, and protein analysis techniques. Both LIs promoted proliferation in porcine dental pulp-derived cell lines (PPU-7), although the cell growth rate between the LIs was different. In addition to proliferation, both LIs also caused apoptosis; however, the apoptotic index for Er:YAG-LI was higher than that for diode-LI. The mRNA level of odontoblastic gene markers—two dentin sialophosphoprotein splicing variants and matrix metalloprotease (MMP)20 were enhanced by diode-LI, whereas MMP2 was increased by Er:YAG-LI. Both LIs enhanced alkaline phosphatase activity, suggesting that they may help induce PPU-7 differentiation into odontoblast-like cells. In terms of mineralization induction, the LIs were not significantly different, although their cell reactivity was likely different. Both LIs activated four MMPs in porcine dental pulp tissues. We helped elucidate how reparative dentin is formed during laser treatments.

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“…Santinoni et al, in 2017, evaluated the efficacy of LLLT in the healing of maxillofacial bone defects. 54 They only reviewed randomized clinical trials in their systematic review. Studies on transverse maxillary expansion and maxillary cystic defects, one study on DO of the mandible, 37 and studies on cases after tooth-extraction, orthodontic tooth movement and periodontal defects were reviewed.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Photobiomodulation on Distraction Osteogenesis

et al. 2019

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Distraction osteogenesis (DO) is a surgical procedure to increase bone height in different body parts. DO includes a surgical incision, wherein the bone is cut and a device is installed for further separation of the two ends by gradual unscrewing of the device screw. New bone gradually forms and fills the gap, and the bone height increases as such. Photobiomodulation (PBM) or low-level laser therapy (LLLT) enhances the formation of soft and hard tissue such as bone and can, therefore, accelerate the process of DO and shorten the duration of different surgical phases of DO such as latency, activation, and consolidation. Different laser types with variable exposure settings and protocols have been used for this purpose. The gallium-aluminum-arsenide (GaAlAs) diode laser is the most commonly used laser type for LLLT. This study reviews 18 published articles on the effects of LLLT on DO and summarizes their findings to further elucidate this topic.

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Influence of low-level laser therapy on the healing of human bone maxillofacial defects: A systematic review

Cited by 67 publications

References 51 publications

Photobiomodulation Therapy (PBMT) Applied in Bone Reconstructive Surgery Using Bovine Bone Grafts: A Systematic Review

Photobiomodulation Therapy (PBMT) Applied in Bone Reconstructive Surgery Using Bovine Bone Grafts: A Systematic Review

Effects of Er:YAG and Diode Laser Irradiation on Dental Pulp Cells and Tissues

The Effect of Photobiomodulation on Distraction Osteogenesis

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