Catalytic topological insulator Bi 2 Se 3 nanoparticles for in vivo protection against ionizing radiation

Zhang, Xiao Dong; Jing, Yaqi; Song, Shasha; Yang, Jiang; Wang, Junying; Xue, Xuhui; Min, Yuho; Park, Gyeongbae; Shen, Xiu; Sun, Yang; Jeong, Unyong

doi:10.1016/j.nano.2017.02.018

Cited by 43 publications

(30 citation statements)

References 44 publications

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“…Alqathami et al validated and quantified the radiation dose enhancement of Bi 2 S 3 and Bi 2 O 3 NPs using phantom cuvettes and novel 3D phantoms and found that the radiation enhancement was greater when irradiating with kV X-rays compared to MV X-rays 157 . Nevertheless, a recent study showed that Bi 2 Se 3 NP, also the catalytic topological insulator, could be used as a potential radioprotective agent due to its ability to scavenge free radicals 158 .…”

Section: Metal-based Nanoenhancers For Ionizing Ramentioning

confidence: 99%

Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells

et al. 2018

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Radiotherapy is one of the major therapeutic strategies for cancer treatment. In the past decade, there has been growing interest in using high Z (atomic number) elements (materials) as radiosensitizers. New strategies in nanomedicine could help to improve cancer diagnosis and therapy at cellular and molecular levels. Metal-based nanoparticles usually exhibit chemical inertness in cellular and subcellular systems and may play a role in radiosensitization and synergistic cell-killing effects for radiation therapy. This review summarizes the efficacy of metal-based NanoEnhancers against cancers in both in vitro and in vivo systems for a range of ionizing radiations including gamma-rays, X-rays, and charged particles. The potential of translating preclinical studies on metal-based nanoparticles-enhanced radiation therapy into clinical practice is also discussed using examples of several metal-based NanoEnhancers (such as CYT-6091, AGuIX, and NBTXR3). Also, a few general examples of theranostic multimetallic nanocomposites are presented, and the related biological mechanisms are discussed.

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Section: Metal-based Nanoenhancers For Ionizing Ramentioning

confidence: 99%

Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells

et al. 2018

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“…85 In a report of irradiated Bi 2 Se 3 -treated mice, it was indicated that the ROS induced in the blood could be oxidized by the nanoparticles. 86 The anti-radical properties of BiONPs could be instigated by the deficiency of oxygen in the material's surface, which might undergo a combination with the ROS. 87 Stewart also had validated that this redox system by BiONPs is irreversible and would continue up to 48 hours only.…”

Section: Intracellular Ros Induced By Radiation With Bb Bc and Bcb mentioning

confidence: 99%

<p>Synergetic Influence of Bismuth Oxide Nanoparticles, Cisplatin and Baicalein-Rich Fraction on Reactive Oxygen Species Generation and Radiosensitization Effects for Clinical Radiotherapy Beams</p>

Sisin¹,

Razak²,

Abidin³

et al. 2020

IJN

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This study aimed to quantify synergetic effects induced by bismuth oxide nanoparticles (BiONPs), cisplatin (Cis) and baicalein-rich fraction (BRF) natural-based agent on the reactive oxygen species (ROS) generation and radiosensitization effects under irradiation of clinical radiotherapy beams of photon, electron and HDR-brachytherapy. The combined therapeutic responses of each compound and clinical radiotherapy beam were evaluated on breast cancer and normal fibroblast cell line. Methods: In this study, individual BiONPs, Cis, and BRF, as well as combinations of BiONPs-Cis (BC), BiONPs-BRF (BB) and BiONPs-Cis-BRF (BCB) were treated to the cells before irradiation using HDR brachytherapy with 0.38 MeV iridium-192 source, 6 MV photon beam and 6 MeV electron beam. The individual or synergetic effects from the application of the treatment components during the radiotherapy were elucidated by quantifying the ROS generation and radiosensitization effects on MCF-7 and MDA-MB-231 breast cancer cell lines as well as NIH/3T3 normal cell line. Results: The ROS generated in the presence of Cis stimulated the most substantial amount of ROS compared to the BiONPs and BRF. Meanwhile, the combination of the components had induced the higher ROS levels for photon beam than the brachytherapy and electron beam. The highest ROS enhancement relative to the control is attributable to the presence of BC combination in MDA-MB-231 cells, in comparison to the BB and BCB combinations. The radiosensitization effects which were quantified using the sensitization enhancement ratio (SER) indicate the highest value by BC in MCF-7 cells, followed by BCB and BB treatment. The radiosensitization effects are found to be more prominent for brachytherapy in comparison to photon and electron beam. Conclusion: The BiONPs, Cis and BRF are the potential radiosensitizers that could improve the efficiency of radiotherapy to eradicate the cancer cells. The combination of these potent radiosensitizers might produce multiple effects when applied in radiotherapy. The BC combination is found to have the highest SER, followed by the BCB combination. This study is also the first to investigate the effect of BRF in combination with BiONPs (BB) and BC (BCB) treatments.

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“…After placing the cell suspension 30 min at 4

C, centrifugation and discarding the supernatant, the sediment is resuspended in 5 mL of a 0.2 M perchloric acid. Suspension was incubated for 30 min at 90

C, filtered after cooling, and the absorbance was measured using an ultraviolet spectrophotometer at 268 nm [ 36 ]. For determination of bone marrow nucleated cells (BMNC), the bone marrow was flushed into 1ml PBS followed by filtered through nylon meshes for cytometric analysis [ 36 ].…”

Section: Methodsmentioning

confidence: 99%

Protective Effects of 2-Amino-5,6-dihydro-4H-1,3-thiazine and Its Derivative against Radiation-Induced Hematopoietic and Intestinal Injury in Mice

Kong

Yang

et al. 2018

IJMS

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Ionizing radiation (IR) acts as an external stimulating factor, when it acts on the body, it will activate NF-κB and cause the up-regulation of inducible nitric oxide synthase (iNOS) and induce a large amount of nitric oxide (NO) production. NO and other reactive nitrogen and oxygen species (RNS and ROS) can cause damage to biological molecules and affect their physiological functions. Our study investigated the protective role of 2-amino-5,6-dihydro-4H-1,3-thiazine hydrobromide (2-ADT) and 2-acetylamino-5,6-dihydro-4H-1,3-thiazine hydrobromide (2-AADT), two nitric oxide synthase inhibitors, against radiation-induced hematopoietic and intestinal injury in mice. Pretreatment with 2-ADT and 2-AADT improved the survival of mice exposed to a lethal dose of radiation, especially, the survival rate of the 2-ADT 20 mg/kg group was significantly higher than that of the vehicle group (p < 0.001). Our findings indicated that the radioprotective actions of 2-ADT and 2-AADT are achieved via accelerating hematopoietic system recovery, decreasing oxidative and nitrosative stress by enhancing the antioxidant defense system and reducing NO as well as peroxynitrite (ONOO−) content, and mitigating the radiation-induced DNA damage evaluated by comet assay. These results suggest that 2-ADT and 2-AADT may have great application potential in ameliorating the damages of radiotherapy.

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Catalytic topological insulator Bi 2 Se 3 nanoparticles for in vivo protection against ionizing radiation

Cited by 43 publications

References 44 publications

Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells

Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells

<p>Synergetic Influence of Bismuth Oxide Nanoparticles, Cisplatin and Baicalein-Rich Fraction on Reactive Oxygen Species Generation and Radiosensitization Effects for Clinical Radiotherapy Beams</p>

Protective Effects of 2-Amino-5,6-dihydro-4H-1,3-thiazine and Its Derivative against Radiation-Induced Hematopoietic and Intestinal Injury in Mice

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