Grape juice increases the BDNF levels but not alter the S100B levels in hippocampus and frontal cortex from male Wistar Rats

Abstract

Several studies have shown that a high consumption of vegetables and fruits is consistently associated with a low risk of oxidative stress-induced diseases, which includes some degenerative diseases such as amyotrophic lateral sclerosis, Alzheimer and Parkinson. Therefore, the objective of this study is to verify the effects of conventional and organic grape juice in the modulation of the neurotrophic factor (BDNF) and astrocytic markers protein (S100B) in hippocampus and frontal cortex of Wistar rats. In this study, 24 male Wistar rats were divided into three groups. To the first one, it was given organic purple grape juice; to the second, conventional grape juice, while the last one received only saline. After 30 days, all rats were sacrificed and hippocampus and frontal cortex were dissected. The animals that received organic and conventional grape juice showed, in frontal cortex, an elevated BNDF levels in relation to saline group. However, S100B levels did not change. These results showed that grape juices are able to modulate important marker in brain tissue, and could be an important factor to prevent brain diseases.

Grape juice consumption and/or exercise training-induced neuroplasticity and memory improvement in healthy elderly women

“…Flavonoids, a large part of polyphenols obtained from plants, are speculated to be effective in the treatment of several CNS disorders such as depression [34,35]. Altogether, these data support the idea previously suggested that natural products rich in flavonoids, which increase the BDNF levels, are promising [19].…”

“…Interestingly, a significant BDNF enhancement after intervention was observed in GJG and GJEG women. These data could be partially related to experimental findings obtained by Dani and colleagues (2017) showing that 30 days of grape juice consumption was able to increase BDNF levels in frontal cortex and hippocampus from Wistar rats, suggesting that this period of consumption is enough to induce neuroplasticity [19]. In this study the authors showed that the flavonols content (mainly epicatechin) could provoke a significant increase in BDNF levels.…”

“…Analysing the phenolic content in our study, we observed that the total phenolic content is like observed in other studying with Brazilian grape juices [31]. However, when we analyse de catechins levels, it was found that the catechin content is the majority, the values are higher than observed by Dani and colleagues (2017) [19] but lower than Toaldo and colleagues (2015) [31]. Some studies are showing that the polyphenols could exerted an important effect in neurotrophin levels, promoting anxiolytic and antidepressive effect in different models [32,33].…”

“…Specifically, it was reported that the oral administration of resveratrol enhanced BDNF levels in rat hippocampus, suggesting that the neuroprotective effects of this compound is related, at least in part, to increased levels of this neurotrophin [17]. In addition, the consumption of grape juice, a very rich source of resveratrol, it was capable to reverse the course of neuronal and behavioural aging [18] and increase BDNF levels in frontal cortex of aged Wistar rats [19]. In humans, the grape juice consumption demonstrated to improve memory and cognitive functions in older adults with early memory decline [20] and mild memory decline [21].…”

Guarana as a source of bioactive compounds

“…The pathophysiology of depression is very complex, but the literature has shown the involvement of brain-derived neurotrophic factor (BDNF) as a crucial biomarker of this neural disorder. Some studies with phenolic compounds from blueberry and grape have shown that phenolic compounds are able to modulate important marker in brain tissue and could be an important factor to prevent brain diseases (Williams et al;Gomez-Pinilla and Nguyen, 2012;Dani et al, 2017). Therefore, further studies with guarana should investigate its role in modulation of BDNF.…”