Analysis of the skin of mice humanized for the immune system

Abstract

Development of new immunotherapeutic strategies relies on the ability to activate the right cells at the right place and at the right moment and on the capacity of these cells to home to the right organ(s). Skin delivery has shown high potency for immunotherapeutic administration. However, an adequate in vivo model of human skin immunity is still a critical bottleneck. We demonstrated here that the skin of human immune system mice is colonized by human hematopoietic cells, mainly human T cells and that complementation with human antigen-presenting cells at the vaccination site allowed the induction of an immune response.

Getting ready for the next decade of Experimental Dermatology

“…[16] In addition, it covers (f) the Immunology of Wound Healing and, [17,18] and, finally, (g) Animal models in Skin Immunology Research. [19,20] Having implemented these modifications, we feel that the jour- Maksim V. Plikus 1,2,3,4 Ralf Paus 5,6,7…”

“…The issue features (a) conceptually intriguing Viewpoint essays on Skin Immunity, and authoritative reviews and original research articles on (b) Cell Biology of Skin Immunity, (c) Immunopathology of Atopic Dermatitis, (d) Psoriasis and (e) Bullous pemphigoid . In addition, it covers (f) the Immunology of Wound Healing and, and, finally, (g) Animal models in Skin Immunology Research …”