The implications of biologic therapy for elective foot and ankle surgery in patients with rheumatoid arthritis

Diaper, Ross; Wong, Ernest; Metcalfe, Stuart

doi:10.1016/j.foot.2017.01.009

Cited by 13 publications

(5 citation statements)

References 46 publications

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“…A 2017 study by the British Society of Rheumatology (BSR) recommends that anti-TNF therapy be paused 3-5x the half-life of the drug prior to surgery. 19 For tocilizumab, a pause 4 weeks prior to surgery is recommended. These recommendations are based on studies which reported higher risk of post-operative infection and poor wound healing in patients receiving biologic therapy.…”

Section: Sequelae For Orthopaedic Surgeonsmentioning

confidence: 99%

Altering the natural history of rheumatoid arthritis: The role of immunotherapy and biologics in orthopaedic care

Girdler

Tang

et al. 2020

Journal of Orthopaedics

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Rheumatoid Arthritis (RA) is an idiopathic disease characterized by systemic inflammation, persistent synovitis, and the presence of autoantibodies. Because of the musculoskeletal deformity caused by RA, multiple orthopaedic procedures are regularly performed as part of the treatment. The changing rates of surgery and the rise in new efficacious medical therapy have improved the prognosis for patients with RA. This review will discuss the natural history of rheumatoid arthritis, common medications used to treat it, how disease progression has changed as a function of new biologic immunotherapy, and the role of orthopaedic intervention in this new landscape of advanced rheumatoid care.

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Section: Sequelae For Orthopaedic Surgeonsmentioning

confidence: 99%

Altering the natural history of rheumatoid arthritis: The role of immunotherapy and biologics in orthopaedic care

Girdler

Tang

et al. 2020

Journal of Orthopaedics

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“…Previous studies reported that there is conflict related to continuing or stopping biologic drug therapy prior to orthopedic procedures in terms of avoiding the possible side effects of these drugs in delayed wound healing [ 44 ]. Previous in vivo studies, focused on the overall impact of biologics upon wound healing, showed that biologics suppress the promotion of key structural proteins, but help to collagen synthesis [ 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review to Identify the Effects of Biologics in the Feet of Patients with Rheumatoid Arthritis

et al. 2020

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Background and Objective: Ninety percent of patients with rheumatoid arthritis (RA) feel foot pain during the disease process. Pharmacological treatment of RA has a systematic effect on the body and includes: Nonsteroidal anti-inflammatory drugs, disease-modifying antirheumatic drugs (DMARDs) and biologics. The objective of our review was to examine the impact of biologics on patients with RA ‘foot. Methods and Material: A systematic review of randomized control trials and observational studies that evaluated the efficacy of biologics against other pharmacological treatment, and included a foot outcome measure. The search covered MEDLINE Ovid, Pubmed, CINAHL, Cochrane Library, Evidence Search, and Web of Science. Risk of bias was evaluated using Cochrane guidance and the Newcastle Ottawa Scale adapted version. Results: A total of eight studies fully met the inclusion criteria: Three randomized control trials, and five observational studies were the basis of our review. A total sample of 1856 RA patients with RA treatment participated. The use of biologics was not associated as a risk factor for post-operative surgical site infection or delayed wound healing. The benefits of biologics, in terms of the disease evolution, were assessed using X-ray. Conclusion: Evidence suggests that the use of biologics is not a risk factor for post-operative surgical site infection or delayed wound healing. The use of biologics presents benefits in terms of the disease evolution assessed through X-ray.

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“…A. Horowitz et al (2018) [22] detected a higher percentage of postoperative infections in the RA patients after the femoral arthrodesis (2.6 % vs. 1.5 %). The primary reason of the RA-related postoperative infectious complications remains unclear: whether it is the medication, chronic systemic and local articular inflammation or various comorbidities.…”

Section: Postoperative Infection Risk In the Ra Patientsmentioning

confidence: 99%

Менеджмент Пацієнтів З Ревматоїдним Артритом У Періопераційному Періоді

Syniachenko¹,

Golovach²,

Yehudіna³

2021

PJS

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Despite the rapid development of biological therapy and decisive establishment of such medication in the rheumatic disease management, rheumatoid arthritis (RA) patients are often subjected to orthopedic surgical interventions [1]. Joint endoprosthetics, arthroplasty, arthroscopic debridement, tendon reconstruction, rheumatoid nodule removal, tunnel and wrist canal decompression-all of these procedures , and numerous others, make up a list of orthopedic interventions indicated to treat rheumatoid arthritis. Furthermore, the RA patients undergo surgery due to their somatic conditions much more often than the rest of the population [1]. Perioperative period involves a number of infection-related risks, such as surgical wound infection and pneumonia. Arthroplasty and other interventions involving prosthet

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The implications of biologic therapy for elective foot and ankle surgery in patients with rheumatoid arthritis

Cited by 13 publications

References 46 publications

Altering the natural history of rheumatoid arthritis: The role of immunotherapy and biologics in orthopaedic care

Altering the natural history of rheumatoid arthritis: The role of immunotherapy and biologics in orthopaedic care

A Systematic Review to Identify the Effects of Biologics in the Feet of Patients with Rheumatoid Arthritis

Менеджмент Пацієнтів З Ревматоїдним Артритом У Періопераційному Періоді

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