Altering the natural history of rheumatoid arthritis: The role of immunotherapy and biologics in orthopaedic care

Abstract

Rheumatoid Arthritis (RA) is an idiopathic disease characterized by systemic inflammation, persistent synovitis, and the presence of autoantibodies. Because of the musculoskeletal deformity caused by RA, multiple orthopaedic procedures are regularly performed as part of the treatment. The changing rates of surgery and the rise in new efficacious medical therapy have improved the prognosis for patients with RA. This review will discuss the natural history of rheumatoid arthritis, common medications used to treat it, how disease progression has changed as a function of new biologic immunotherapy, and the role of orthopaedic intervention in this new landscape of advanced rheumatoid care.

A Comprehensive Review on Rheumatoid Arthritis

“…The outcome of the disease is inflammation of the joints systemically, persistent synovitis, damage of the tissues due to the release of cytokines and inflammation due to imbalance between the autoimmune cells. The autoimmune antibodies will damage the tissues [2]. The occurrence of rheumatoid arthritis is 1% in the adult population.…”