Association between the Matrix Metalloproteinase-9 rs3918242 Polymorphism and Ischemic Stroke Susceptibility: A Meta-Analysis

He, Tao; Wang, Jie; Wang, Xiaoli; Deng, Wenshuai; Sun, Peng

doi:10.1016/j.jstrokecerebrovasdis.2016.12.036

Cited by 24 publications

(16 citation statements)

References 30 publications

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“…Matrix metalloproteinases (MMPs) belong to the family of zinc-dependent proteolytic enzymes, which are inflammatory mediators playing an important role in physiological and pathological processes of the extracellular matrix (ECM) 10 . Until now, 23 different MMPs have been found in humans 11 .…”

Section: Introductionmentioning

confidence: 99%

Connectivity map identifies luteolin as a treatment option of ischemic stroke by inhibiting MMP9 and activation of the PI3K/Akt signaling pathway

Luo

et al. 2019

Exp Mol Med

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This study aimed to explore potential new drugs in the treatment of ischemic stroke by Connectivity Map (CMap) and to determine the role of luteolin on ischemic stroke according to its effects on matrix metalloproteinase-9 (MMP9) and PI3K/Akt signaling pathway. Based on published gene expression data, differentially expressed genes were obtained by microarray analysis. Potential compounds for ischemic stroke therapy were obtained by CMap analysis. Cytoscape and gene set enrichment analysis (GSEA) were used to discover signaling pathways connected to ischemic stroke. Cell apoptosis and viability were, respectively, evaluated by flow cytometry and an MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide) assay. Quantitative real-time polymerase chain reaction (qRT-PCR) and western blot analysis were used to test the expression of MMP9 and the PI3K/Akt signaling pathway-related proteins in human brain microvascular endothelial cells (HBMECs) and tissues. Additionally, the infarct volume after middle cerebral artery occlusion (MCAO) was determined by a TTC (2,3,5-triphenyltetrazolium chloride) assay. The microarray and CMap analyses identified luteolin as a promising compound for future therapies for ischemic stroke. Cytoscape and GSEA showed that the PI3K/Akt signaling pathway was crucial in ischemic stroke. Cell experiments revealed that luteolin enhanced cell viability and downregulated apoptosis via inhibiting MMP9 and activating the PI3K/Akt signaling pathway. Experiments performed in vivo also demonstrated that luteolin reduced the infarct volume. These results suggest that luteolin has potential in the treatment of ischemic stroke through inhibiting MMP9 and activating PI3K/Akt signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Connectivity map identifies luteolin as a treatment option of ischemic stroke by inhibiting MMP9 and activation of the PI3K/Akt signaling pathway

Luo

et al. 2019

Exp Mol Med

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“…The dataset contains the raw data (supplementary Table), frequencies of alleles and genotypes ( Table 1 ) for three SNPs of two MMP genes (rs1799750 MMP1 , rs3918242 and rs17576 MMP9 ) in Russian patients diagnosed with POAG, EH, and PU. These polymorphisms were previously reported for their association with POAG, EH, and PU ( Table 2 ) [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] . The studied SNPs manifest the regulatory potential ( Table 3 ), which is evidenced by several eQTLs ( Table 4 ) and splicing QTLs ( Table 5 ).…”

Section: Data Descriptionmentioning

confidence: 99%

Dataset of allele and genotype frequencies of the three functionally significant polymorphisms of the MMP genes in Russian patients with primary open-angle glaucoma, essential hypertension and peptic ulcer

et al. 2020

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Data on the allele and genotype frequencies of the three functionally significant single nucleotide polymorphisms (SNPs) of the matrix metalloproteinases ( MMP ) genes (rs1799750 MMP1 , rs3918242 and rs17576 MMP9 ) in Russian patients with primary open-angle glaucoma (POAG), essential hypertension (EH) and peptic ulcer (PU) are presented. Association studies identified these SNPs as possible significant markers associated with many multifactorial disorders, including POAG, EH, and PU. The frequencies of alleles and genotypes of the three SNPs in Russian patients with POAG, EH, and PU were presented separately for the entire study sample, females, and males, respectively. The data can be used as a reference for the Russian population.

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“…Matrix Metalloproteinases (MMPs), a family of zinc-dependent proteolytic enzymes, which plays a key role in the degradation of ECM and the injury and repair of liver structure, and is also closely related to the progress and repair of liver brosis [3]. Matrix Metalloproteinase-9 (MMP-9), also known as gelatinase B [4], is one of the important components of ECM degradation and has a bearing on the dynamic changes of liver brosis.…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Matrix Metalloproteinase-9 1562C/T Polymorphism and Liver Diseases: A Meta-Analysis

Yang

Cheng

et al. 2021

Preprint

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Background Liver diseases have an adverse impact on human’s body and life, and many factors, such as viruses, genes, etc., are closely related to the occurrence and development of liver diseases. This study tries to explore the relationship between liver diseases and one of the genetic polymorphisms (MMP-9-1562 C/T polymorphism) by meta-analysis, to provide basis for the prevention and treatment of liver diseases and to promote the study of the mechanism of liver diseases by the exploration of etiology. Methods Relevant literatures from PubMed, EMBASE, Web of Science, CNKI, Chinese biomedical literature database and other databases were searched from building the database to Dec. 2020. Meta-analysis method was adopted and Review Manager 5.3 software was used for analysis. Results A total of 7 studies with 1415 cases and 1592 controls were included in this meta-analysis. A significant association between MMP-9-1562 C/T polymorphism and liver diseases in the homozygous and recessive models (TT vs CC: OR = 1.82,95%CI = 1.28–2.59, P = 0.0009; TT vs CT + CC: OR = 1.73,95%CI = 1.24–2.41, P = 0.001). However, no association in heterozygote and dominant models (CT vs CC: OR = 1.05, 95%CI = 0.76–1.45, P = 0.78; TT + CT vs CC: OR = 1.17, 95%CI = 0.82–1.67, P = 0.38). Conclusions Our meta-analysis suggested that the TT genotype of MMP-9-1562 C/T polymorphism might be associated with the risk of nonalcoholic fatty liver disease, hepatocellular carcinoma, and primary liver cancer. If these diseases are present, screening genotype of MMP-9 and aggressive treatment of the primary disease is necessary.

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Association between the Matrix Metalloproteinase-9 rs3918242 Polymorphism and Ischemic Stroke Susceptibility: A Meta-Analysis

Cited by 24 publications

References 30 publications

Connectivity map identifies luteolin as a treatment option of ischemic stroke by inhibiting MMP9 and activation of the PI3K/Akt signaling pathway

Connectivity map identifies luteolin as a treatment option of ischemic stroke by inhibiting MMP9 and activation of the PI3K/Akt signaling pathway

Dataset of allele and genotype frequencies of the three functionally significant polymorphisms of the MMP genes in Russian patients with primary open-angle glaucoma, essential hypertension and peptic ulcer

Relationship Between Matrix Metalloproteinase-9 1562C/T Polymorphism and Liver Diseases: A Meta-Analysis

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