Erratum: Clinical impact of bone marrow morphology for the diagnosis of essential thrombocythemia: comparison between the BCSH and the WHO criteria

Gisslinger, Heinz; Jeryczynski, Georg; Gisslinger, Bettina; Wölfler, Albert; Burgstaller, Sonja; Buxhofer‐Ausch, Veronika; Schalling, Martin; Krauth, M.-T.; Schiefer, AI; Kornauth, Christoph; Simonitsch‐Klupp, Ingrid; Beham‐Schmid, Christine; Müllauer, Leonhard; Thiele, Jüergen

doi:10.1038/leu.2016.291

Cited by 7 publications

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“…Patients provided informed consent and data were collected from the electronic patient record. All patients were diagnosed with the World Health Organization (WHO) criteria for hematological diseases (3,7). The decision of whether to perform plateletpheresis is individualized based on the patient's characteristics and physician preferences.…”

Section: Patientsmentioning

confidence: 99%

“…Myeloproliferative neoplasms (MPN) are a group of malignant proliferative disease of the bone marrow that originate from pluripotent hematopoietic stem cells, and include disorders such as polycythemia vera (PV) (1), essential thrombocythemia (ET) (2,3), and primary myelofibrosis (PMF) (4). Excessive proliferation of myeloid cells in MPN may deteriorate into thrombosis, bleeding, myelofibrosis, and may finally convert to acute leukemia (5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic Plateletpheresis in Patients With Thrombocytosis: Gender, Hemoglobin Before Apheresis Significantly Affect Collection Efficiency

et al. 2021

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Background: Thrombocytosis is a common symptom in myeloproliferative neoplasms (MPN), and excessive proliferation may deteriorate into thrombosis, bleeding, myelofibrosis, and may ultimately convert to acute leukemia. This study aimed to investigate the collection efficiency of plateletpheresis (CEPP) and factors influencing its efficacy in patients with thrombocytosis.Materials and Methods: From September 2010 to December 2016, 81 patients from two institutions in China with myeloproliferative neoplasms and thrombocytosis accompanied by severe symptoms were treated with plateletpheresis by Fresenius COM. TEC machine.Results: After apheresis, the median CEPP was 20.71% (IQR: 9.99–36.69%) and median PLT reduction rate was 25.87% (IQR: 21.78–36.23%). Further analysis showed that no significant difference was observed between PLT count with 800–1,000 × 109/L and > 1,000 × 109/L. The PLT counts significantly decreased (P < 0.001) after plateletpheresis, the red blood cell (RBC), white blood cell (WBC), hemoglobin (HGB), and hematocrit (HCT) levels showed no significant differences before- or after- plateletpheresis. Multivariate analysis showed that female sex (P = 0.009) and HGB (P = 0.010) before apheresis were associated with CEPP. Female (P = 0.022), HCT (P = 0.001) and blood volume (P = 0.015) were associated with the PLT reduction rate. Furthermore, symptoms were relieved after apheresis in patients whose PLT count was 800–1,000 × 109/L accompanied with symptoms.Conclusions: It is reasonable to perform plateletpheresis when the PLT count is over 800 × 109/L and patients are complicated by clinical symptoms such as dizziness, headache, somnolence, and stupor. Plateletpheresis is effective in removing PLTs especially in females with high HGB.

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Section: Patientsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Therapeutic Plateletpheresis in Patients With Thrombocytosis: Gender, Hemoglobin Before Apheresis Significantly Affect Collection Efficiency

et al. 2021

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“…The morphological examination of nucleated cells in bone marrow (BM) is a critical diagnostic procedure for hematological diseases, heavily reliant on the expertise of pathologists. However, this process is timeconsuming and labor-intensive, potentially leading to delays in treatment initiation for patients [1][2][3][4][5][6][7][8][9]. Therefore, there is an urgent need for new technology to assist with this manual inspection.…”

Section: Introductionmentioning

confidence: 99%

Application of Morphogo based on convolutional neural network for morphological identification of bone marrow nucleated cells

Zhang,

Hua

et al. 2024

Preprint

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Introduction: The morphological examination of bone marrow (BM) cells, commonly used for diagnosing hematological diseases, heavily relies on the expertise of pathologists. This approach is time-consuming, labor-intensive, subjective, and lacks objectivity. Therefore, it is crucial to develop automated analysis systems to aid in the diagnosis of hematological diseases. Methods The BM smears from patients with hematological diseases were collected from Dian Diagnostics between September 2021 and December 2021. These smears were classified into five groups based on varying degrees of cell morphological alterations. Images of the BM nucleated cells were captured using the Morphogo system, and its performance in cell identification was compared with that of pathologists. Results The Morphogo system demonstrated a high performance in identifying BM nucleated cells, with a sensitivity of 0.9362, specificity of 0.9977, PPV of 0.8354, NPV of 0.9974, and accuracy of 0.9954. Comparison between the percentage of BM nucleated cells identified by the Morphogo system and pathologists showed almost perfect agreement, with an average Kappa value of 0.8695 for 25 cell classes. The practical utility of the Morphogo system was evaluated in hematological diseases, with pathologists achieving averaged sensitivity, specificity, PPV, NPV and accuracy ranging from 0.9098 to 0.9868 when using the system for disease diagnosis. The diagnostic results were consistent with those made by pathologists using a microscope, with an average Kappa value of 0.9096. Conclusion Morphogo system had the potential to assist pathologists in diagnosis of hematological diseases by improving the efficiency of identification of BM nucleated cells.

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WHO-Klassifikation myeloischer Neoplasien

Wickenhauser

2018

Pathologe

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Erratum: Clinical impact of bone marrow morphology for the diagnosis of essential thrombocythemia: comparison between the BCSH and the WHO criteria

Cited by 7 publications

References 0 publications

Therapeutic Plateletpheresis in Patients With Thrombocytosis: Gender, Hemoglobin Before Apheresis Significantly Affect Collection Efficiency

Therapeutic Plateletpheresis in Patients With Thrombocytosis: Gender, Hemoglobin Before Apheresis Significantly Affect Collection Efficiency

Application of Morphogo based on convolutional neural network for morphological identification of bone marrow nucleated cells

WHO-Klassifikation myeloischer Neoplasien

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