Evidence for alterations of the right inferior and superior longitudinal fasciculi in patients with social anxiety disorder

Tükel, Raşit; Ulasoglu-Yildiz, Cigdem; Ertekin, Erhan; Kurt, Elif; Koyuncu, Ahmet; Aydın, Kubilay

doi:10.1016/j.brainres.2017.02.016

Cited by 10 publications

(3 citation statements)

References 36 publications

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“…The increased MD indicates impaired fiber integrity and has been associated with reduced cognitive 7,31,32 and affective functions 33,34 . In CDs, the increased MD in the left C(cg) may indicate increased stress, depression and anxiety in these subjects [35][36][37] . Increased MD in the left IFOF and bilateral SLF may indicate decreased language function (both the IFOF and SLF are involved in language function 22,38,39 ).…”

Section: Discussionmentioning

confidence: 97%

“…The cingulum is also activated in both normal and pathologic anxiety 27,56 . Second, MD and RD values in the ILF has been found to be negatively correlated with anxiety scores, which is due to the abnormal functional connectivity of the fusiform and inferior temporal gyrus with the amygdala and insula (regions responsible for emotional processing [57][58][59][60][61][62] which is also seen in SAD patients 35 . Third, the FMa, which is located at the interface between crossing fibers from the splenium of the corpus callosum and ILF 63 , has been found to be associated with anxiety symptoms 64 .…”

Section: Discussionmentioning

confidence: 99%

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Alterations in brain white matter microstructural properties in patients with Crohn’s disease in remission

Hou

Dodd

Nair

et al. 2020

Sci Rep

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Patients with inflammatory bowel disease have been shown to have abnormal brain morphometry or function, which are associated with psychological symptoms such as stress, depression or anxiety. The present work recruited 20 Crohn's disease patients in remission (CDs) and 20 age-gender-handednesseducation matched healthy controls (HCs) and compared their brain white matter microstructural properties using Diffusion Tensor Imaging (DTI). Additionally, we examined the correlations between the microstructural properties and cognition (verbal fluency language task, VF) and affect (anxiety) in both groups as well as disease duration in CDs. Results showed that CDs exhibited significant alterations in microstructural properties compared to Hcs in various white matter tracts relevant to language function despite no significant difference in VF scores. Furthermore, CDs' microstructural changes exhibited correlations with anxiety level and disease duration. These findings suggest that CD patients may experience changes in white matter microstructural properties which may be a biomarker of neuropsychiatric comorbidities of CD.Crohn's disease (CD), as one subtype of inflammatory bowel disease (IBD), is thought to be caused by disruption of the normal immune system and also perhaps by altered intestinal permeability 1 and it can affect any gastrointestinal part from the mouth to the anus 2 . The impact of IBD may also extend to the brain and lead to anatomical and functional changes. Several studies have reported anatomical and functional brain changes in CD patients, possibly due to increased proinflammatory cytokines or chemokines and microglial cells which play an important role in communication between the brain, gut, and systemic immune system. These systemic changes have been posited to lead to a cascade of neuroplastic events that result in anatomical or functional brain changes that affect cognitive or affective abilities 3-5 . The observed brain changes might also account for the increased sensitivity of the CD patients to their related external environment which has been described among CDs and the inadequate ability to modulate cognitive and emotional states 3,6,7 . Moreover, the comorbidities assciated with IBD such as psychological stress, anxiety, depression, chronic pain may also influence anatomical and functional changes in the brain 1 .A growing body of evidence suggests that abnormalities in the brain morphometry or function of CD patients may correlate with cognitive and affective changes. Several studies, in CD patients, have reported changes in brian morphometry compared to age-matched healthy controls (HCs). For exmaple, Bao et al. reported decreased cortical thickness in several regions and this decrease was correlated to pain score or disease duration 8 . Increased cortical thickness has also been reported as well as decreased sub-cortical volumes have been correlated to pain score or disease duration 3 ; Zikou et al. showed decreased volume in the bilateral fusiform, inferior temporal gyrus (emotional...

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Alterations in brain white matter microstructural properties in patients with Crohn’s disease in remission

Hou

Dodd

Nair

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The temporal network identified in our study mainly involves the inferior longitudinal fasciculus (ILF) extending to the uncinate fasciculus, which interconnects the limbic regions such as the amygdala and OFC ( Kiernan, 2012 ; Latini, 2015 ; Olson et al., 2007 ). Furthermore, diffusion tensor imaging studies in SAD have shown reduced fractional anisotropy in ILF ( Tükel et al., 2017 ) and uncinate fasciculus ( Baur et al., 2013 ), which indicates disrupted WM microstructure. We speculate that the reduced FC between the GM of limbic network and WM of lateral temporal network may be related to the disrupted WM microstructure of the lateral temporal network, and may be interpreted as the neural underpinnings of deficit of negative expression processing in SAD patients.…”

Section: Discussionmentioning

confidence: 99%

Large-scale dysfunctional white matter and grey matter networks in patients with social anxiety disorder

et al. 2022

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White Matter-Based Structural Brain Network of Anxiety

Lee

2020

Advances in Experimental Medicine and Biology

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Evidence for alterations of the right inferior and superior longitudinal fasciculi in patients with social anxiety disorder

Cited by 10 publications

References 36 publications

Alterations in brain white matter microstructural properties in patients with Crohn’s disease in remission

Alterations in brain white matter microstructural properties in patients with Crohn’s disease in remission

Large-scale dysfunctional white matter and grey matter networks in patients with social anxiety disorder

White Matter-Based Structural Brain Network of Anxiety

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