White Matter-Based Structural Brain Network of Anxiety

Lee, Kang Soo; Lee, Sang Hyuk

doi:10.1007/978-981-32-9705-0_4

Cited by 11 publications

(11 citation statements)

References 67 publications

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“…Indeed, the white matter connectivity via uncinate fasciculus between orbitofrontal and middle temporal areas, including amygdala interactions, has been associated especially with emotional memory (Granger et al, 2021) and anxiety (Lee & Lee, 2020). The increased engagement of these areas during anxious evoking compared to neutral "rumination" could thus, theoretically, relate to a stronger emphasis of emotional memory.…”

Section: Average Patterns Over Participantsmentioning

confidence: 99%

Penalized canonical correlation analysis reveals a relationship between temperament traits and brain oscillations during mind wandering

Heinilä,

Hyvärinen,

Parkkonen

et al. 2024

Brain and Behavior

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IntroductionThere has been a growing interest in studying brain activity under naturalistic conditions. However, the relationship between individual differences in ongoing brain activity and psychological characteristics is not well understood. We investigated this connection, focusing on the association between oscillatory activity in the brain and individually characteristic dispositional traits. Given the variability of unconstrained resting states among individuals, we devised a paradigm that could harmonize the state of mind across all participants.MethodsWe constructed task contrasts that included focused attention (FA), self‐centered future planning, and rumination on anxious thoughts triggered by visual imagery. Magnetoencephalography was recorded from 28 participants under these 3 conditions for a duration of 16 min. The oscillatory power in the alpha and beta bands was converted into spatial contrast maps, representing the difference in brain oscillation power between the two conditions. We performed permutation cluster tests on these spatial contrast maps. Additionally, we applied penalized canonical correlation analysis (CCA) to study the relationship between brain oscillation patterns and behavioral traits.ResultsThe data revealed that the FA condition, as compared to the other conditions, was associated with higher alpha and beta power in the temporal areas of the left hemisphere and lower alpha and beta power in the parietal areas of the right hemisphere. Interestingly, the penalized CCA indicated that behavioral inhibition was positively correlated, whereas anxiety was negatively correlated, with a pattern of high oscillatory power in the bilateral precuneus and low power in the bilateral temporal regions. This unique association was found in the anxious‐thoughts condition when contrasted with the focused‐attention condition.ConclusionOur findings suggest individual temperament traits significantly affect brain engagement in naturalistic conditions. This research underscores the importance of considering individual traits in neuroscience and offers an effective method for analyzing brain activity and psychological differences.

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Section: Average Patterns Over Participantsmentioning

confidence: 99%

Penalized canonical correlation analysis reveals a relationship between temperament traits and brain oscillations during mind wandering

Heinilä,

Hyvärinen,

Parkkonen

et al. 2024

Brain and Behavior

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“…The hook-shaped fiber plays a putative role in social emotional processing ( 5 ). Additionally, it is a key component of the fronto-limbic network, which plays a significant role in OCD pathophysiology ( 31 ). Evidence suggests that higher FA together with lower RD is related to increased myelination, dense axonal packing, white matter maturation, and neuronal remodeling ( 32 – 34 ).…”

Section: Discussionmentioning

confidence: 99%

Abnormal focal segments in left uncinate fasciculus in adults with obsessive–compulsive disorder

Zhang

Jiang

et al. 2023

Front. Psychiatry

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BackgroundAlthough the specific role of the uncinate fasciculus (UF) in emotional processing in patients with obsessive–compulsive disorder (OCD) has been investigated, the exact focal abnormalities in the UF have not been identified. The aim of the current study was to identify focal abnormalities in the white matter (WM) microstructure of the UF and to determine the associations between clinical features and structural neural substrates.MethodsIn total, 71 drug-naïve patients with OCD and 81 age- and sex-matched healthy controls (HCs) were included. Automated fiber quantification (AFQ), a tract-based quantitative approach, was adopted to measure alterations in diffusion parameters, including fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD), along the trajectory of the UF. Additionally, we utilized partial correlation analyses to explore the relationship between the altered diffusion parameters and clinical characteristics.ResultsOCD patients showed significantly higher FA and lower RD at the level of the temporal and insular portions in the left UF than HCs. In the insular segments of the left UF, increased FA was positively correlated with the Hamilton Anxiety Scale (HAMA) score, while decreased RD was negatively correlated with the duration of illness.ConclusionWe observed specific focal abnormalities in the left UF in adult patients with OCD. Correlations with measures of anxiety and duration of illness underscore the functional importance of the insular portion of left UF disturbance in OCD patients.

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“…Although it is not clear whether WM anatomical connectivity architecture abnormality in PTSD is a developmental/genetic preexisting predisposition or is an outcome of the traumatic exposure, the results of the current study support the former. While previous studies conducted with posttraumatic patients (De Bellis et al., 2002; Kitayama et al., 2007; Saar‐Ashkenazy et al., 2014, 2016; Siehl et al., 2020; Villarreal et al., 2004) and other stress related disorders (Baur et al., 2011; Brambilla et al., 2012; Kim et al., 2017; Liao et al., 2014; Wang et al., 2016; Zhang et al., 2013; see also a review by Lee & Lee, 2020) reported various WM brain alterations, the major drawback of the majority of these studies is that they cannot determine causality, that is, they lack answer to the question whether the reported differences are a result of the trauma/disorder or represent an existing predisposition for stress disorders.…”

Section: Discussionmentioning

confidence: 99%

White‐matter correlates of anxiety: The contribution of the corpus‐callosum to the study of anxiety and stress‐related disorders

Saar‐Ashkenazy

Guez

Jacob

et al. 2022

Int J Methods Psych Res

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ObjectivesTraumatic stress has been associated with increased risk for brain alterations and development of anxiety disorders. Studies conducted in posttraumatic patients have shown white‐mater volume and diffusion alterations in the corpus‐callosum. Decreased cognitive performance has been demonstrated in acute stress disorder and posttraumatic patients. However, whether cognitive alterations result from stress related neuropathology or reflect a predisposition is not known. In the current study, we examined in healthy controls, whether individual differences in anxiety are associated with those cognitive and brain alterations reported in stress related pathologies.MethodsTwenty healthy volunteers were evaluated for anxiety using the state‐trait inventory (STAI), and were tested for memory performance. Brain imaging was employed to extract volumetric and diffusion characteristics of the corpus‐callosum.ResultsSignificant correlations were found between trait anxiety and all three diffusion parameters (fractional‐anisotropy, mean and radial‐diffusivity). Associative‐memory performance and corpus‐callosum volume were also significantly correlated.ConclusionWe suggest that cognitive and brain alterations, as tested in the current work and reported in stress related pathologies, are present early and possibly persist throughout life. Our findings support the hypothesis that individual differences in trait anxiety predispose individuals towards negative cognitive outcomes and brain alterations, and potentially to stress related disorders.

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White Matter-Based Structural Brain Network of Anxiety

Cited by 11 publications

References 67 publications

Penalized canonical correlation analysis reveals a relationship between temperament traits and brain oscillations during mind wandering

Penalized canonical correlation analysis reveals a relationship between temperament traits and brain oscillations during mind wandering

Abnormal focal segments in left uncinate fasciculus in adults with obsessive–compulsive disorder

White‐matter correlates of anxiety: The contribution of the corpus‐callosum to the study of anxiety and stress‐related disorders

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