2017
DOI: 10.6061/clinics/2017(01)06
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A novel model to estimate lymph node metastasis in endometrial cancer patients

Abstract: OBJECTIVES:To evaluate the postoperative pathological characteristics of hysterectomy specimens, preoperative cancer antigen (CA)-125 levels and imaging modalities in patients with endometrial cancer and to build a risk matrix model to identify and recruit patients for retroperitoneal lymphadenectomy.METHODS:A total of 405 patients undergoing surgical treatment for endometrial cancer were retrospectively reviewed and analyzed. Clinical (age and body mass index), laboratory (CA-125), radiological (lymph node ev… Show more

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Cited by 10 publications
(11 citation statements)
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“…14 Other studies focused on a risk matrix model to identify high-risk parameters necessitating lymphadenectomy and to decide the risks and benefits of lymphadenectomy. 15 A long-term argument against routine lymph node dissection was that the procedure could cause several complications such as bowel obstruction, deep venous thrombus and chronic lymphedema. 16 To decrease complications related with lymphadenectomy and better select patients who would benefit most from lymphadenectomy, sentinel lymph node biopsy has been developed.…”
Section: Discussionmentioning
confidence: 99%
“…14 Other studies focused on a risk matrix model to identify high-risk parameters necessitating lymphadenectomy and to decide the risks and benefits of lymphadenectomy. 15 A long-term argument against routine lymph node dissection was that the procedure could cause several complications such as bowel obstruction, deep venous thrombus and chronic lymphedema. 16 To decrease complications related with lymphadenectomy and better select patients who would benefit most from lymphadenectomy, sentinel lymph node biopsy has been developed.…”
Section: Discussionmentioning
confidence: 99%
“…For example, studies have confirmed that high-grade endometrioid adenocarcinoma has great heterogeneous, POLE mutations are significantly associated with favorable clinical outcomes in high-grade endometrioid endometrial cancer, which implies that highgrade endometrioid endometrial cancer should be reevaluated by molecular parameters (32). Therefore, adding molecular classification to the predictive model is the trend of future research (4). In this study, the abovementioned P53 molecular classification was incorporated into our model in the form of immunohistochemical markers.…”
Section: Discussionmentioning
confidence: 99%
“…Lymph node metastasis (LNM) is a significant risk factor for the prognosis of these patients (3). Recently, the role of systematic lymph node dissection in the treatment of EC has become controversial (4). Random tests have shown that conventional lymph node dissection does not lead to a survival benefit in patients with early-stage EC (3).…”
Section: Introductionmentioning
confidence: 99%
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“…The type of surgery used to treat endometrial carcinomas changed considerably at our institution over the study period, with a marked increase in the performance of minimally invasive (traditional laparoscopic and robotic) surgeries [27][28][29]. Currently, laparoscopy is the treatment of choice, employed in >90% of cases.…”
Section: Plos Onementioning
confidence: 99%