Hepatic Epithelioid Hemangioendothelioma and Adult Liver Transplantation: Proposal for a Prognostic Score Based on the Analysis of the ELTR-ELITA Registry

Lai, Quirino; Feys, Estelle; Karam, Vincent; Adam, René; Klempnauer, Jürgen; Oliverius, Martin; Mazzaferro, Vincenzo; Pascher, Andreas; Remiszewski, Piotr; Isoniemi, Helena; Pirenne, Jacques; Foss, Aksel; Ericzon, Bo Göran; Marković, Slobodan; Lerut, Jan

doi:10.1097/tp.0000000000001603

Cited by 79 publications

(54 citation statements)

References 41 publications

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“…Smaller studies included hEHE patients who underwent liver transplantation without extrahepatic disease, with very good outcomes. 8,[15][16][17] Systemic treatment for metastatic or progressed hEHE is still not well established. There is no consensus on the therapeutic algorithm which clinicians should follow.…”

Section: Discussionmentioning

confidence: 99%

<p>Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?</p>

Kyriazoglou

Koutsoukos

Zagouri

et al. 2020

TCRM

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Epithelioid hemangioendothelioma (EHE) is a rare vascular malignant tumor with indolent course. Liver transplantation for local disease is the treatment of choice. In the metastatic setting there is no consensus regarding the appropriate systemic treatment. We present two cases of metastatic hepatic epithelioid hemangioendothelioma (hEHE) treated with the combination of Doxorubicin and Olaratumab. Both patients showed Stable Disease (SD) as a response, after the completion of six cycles of this combination therapy.

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Section: Discussionmentioning

confidence: 99%

<p>Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?</p>

Kyriazoglou

Koutsoukos

Zagouri

et al. 2020

TCRM

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“…LT is associated with greater blood loss, longer operating procedures, and longer hospital stay [ 20 ] when compared with LR. For patients receiving LT, the reported early (≤ 3 months) and late (> 3 months) mortality rates were 1% –5% and 22% [ 15 , 21 ], respectively, which were higher than the mortality rates of LR (0% –1%) [ 22 , 23 ]. In a previous case, multiple bone and spleen metastases developed within 3 months after LT [ 3 ], suggesting the possibility of occasional aggressive tumor recurrence after LT.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic repeat liver resection for hepatic epithelioid hemangioendothelioma

et al. 2020

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Background Optimal treatment for patients with hepatic epithelioid hemangioendothelioma (HEHE) remains unclear. Laparoscopic repeat liver resection (LR) is a minimally invasive and potentially effective surgical option for multiple HEHEs. Case presentation A 42-year-old woman with no relevant history was admitted for multiple liver tumors. Six tumors were observed on T2-weighted magnetic resonance imaging (MRI) including one in S2, two in S3, two in S7, and one in S8. Pathological evaluation of percutaneous tumor biopsy tissue suggested a diagnosis of HEHE and laparoscopic LR was planned. The procedure began with partial resection of S7 and partial resection of S8 and left lateral sectionectomy were performed. Another tumor was found intraoperatively on the surface of S6, necessitating removal by partial resection. Pathological evaluation of the resected tumor tissue from all seven tumors concurred with that of the preoperative biopsy. The patient was discharged on postoperative day 6 without any complications. A follow-up MRI 15 months after the primary surgery revealed one tumor each in S4, S6, and S8. Laparoscopic repeat LR was performed. The patient was discharged on postoperative day 5 without any complications. All three recurrent tumors were pathologically confirmed as HEHEs. Conclusions We successfully treated primary and recurrent HEHEs with laparoscopic LR, which is a reasonable minimally invasive procedure considering the possibility of multiple courses of liver surgery in patients with HEHE.

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“…LT was recommended in those presenting with these risk factors. Lai et al analyzed data from the ELTR and proposed a risk score (HEHE-LT) to stratify patients to identify those who would benefit from LT according to risk of recurrence after transplantation (9). The risk factors associated with recurrence that were identified include pathological invasion of hilar lymph nodes and macrovasculature, and, interestingly, a short waiting time to transplantation (<120 days).…”

Section: Discussionmentioning

confidence: 99%

The Role of Local Therapy in Multi-focal Epithelioid Haemangioendothelioma

et al. 2019

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Hepatic Epithelioid Hemangioendothelioma and Adult Liver Transplantation: Proposal for a Prognostic Score Based on the Analysis of the ELTR-ELITA Registry

Cited by 79 publications

References 41 publications

<p>Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?</p>

<p>Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?</p>

Laparoscopic repeat liver resection for hepatic epithelioid hemangioendothelioma

The Role of Local Therapy in Multi-focal Epithelioid Haemangioendothelioma

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