Transmission of Zika Virus — Haiti, October 12, 2015–September 10, 2016

Journel, Ito; Andrécy, Lesly L.; Metellus, Dudley; Pierre, Jean Samuel; Faublas, Rose Murka; Juin, Stanley; Dismer, Amber; Fitter, David; Neptune, Daniel; Laraque, Marie José; Corvil, Salomon; Pierre, Manise; Buteau, Josiane; Lafontant, Donald; Patel, Roopal; Lemoine, Jean Frantz; Lowrance, David; Charles, Macarthur; Boncy, Jacques; Adrien, Paul

doi:10.15585/mmwr.mm6606a4

Cited by 15 publications

(15 citation statements)

References 2 publications

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“…After reviewing the full text, 249 publications were included ( Table 2, Figure 3). Of these publications, 195 reported on congenital abnormalities linked to ZIKV 24– 217 and 59 on GBS 4, 44, 118, 201, 203, 206, 218– 270 . Five outbreak reports described both outcomes 44, 118, 201, 203, 206 .…”

Section: Resultsmentioning

confidence: 99%

Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: A living systematic review

et al. 2019

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Background: The Zika virus (ZIKV) caused a large outbreak in the Americas leading to the declaration of a Public Health Emergency of International Concern in February 2016. A causal relation between infection and adverse congenital outcomes such as microcephaly was declared by the World Health Organization (WHO) informed by a systematic review structured according to a framework of ten dimensions of causality, based on the work of Bradford Hill. Subsequently, the evidence has continued to accumulate, which we incorporate in regular updates of the original work, rendering it a living systematic review. Methods: We present an update of our living systematic review on the causal relation between ZIKV infection and adverse congenital outcomes and between ZIKV and GBS for four dimensions of causality: strength of association, dose-response, specificity, and consistency. We assess the evidence published between January 18, 2017 and July 1, 2019. Results: We found that the strength of association between ZIKV infection and adverse outcomes from case-control studies differs according to whether exposure to ZIKV is assessed in the mother (OR 3.8, 95% CI: 1.7-8.7, I2=19.8%) or the foetus/infant (OR 37.4, 95% CI: 11.0-127.1, I2=0%). In cohort studies, the risk of congenital abnormalities was 3.5 times higher after ZIKV infection (95% CI: 0.9-13.5, I2=0%). The strength of association between ZIKV infection and GBS was higher in studies that enrolled controls from hospital (OR: 55.8, 95% CI: 17.2-181.7, I2=0%) than in studies that enrolled controls at random from the same community or household (OR: 2.0, 95% CI: 0.8-5.4, I2=74.6%). In case-control studies, selection of controls from hospitals could have biased results. Conclusions: The conclusions that ZIKV infection causes adverse congenital outcomes and GBS are reinforced with the evidence published between January 18, 2017 and July 1, 2019.

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Section: Resultsmentioning

confidence: 99%

Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: A living systematic review

et al. 2019

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“…We incidentally recently conducted a Pubmed search for “Zika and Cases,” limited to “5 years” and “English.” The search yielded 346 results; 57 of these studies reported on the symptoms experienced by Zika patients, and 17 studies included pregnant patients infected with Zika virus who reported on a congenital outcome. We performed a Chi‐Square test to determine if the difference between the congenital outcomes in those patients with and without skin involvement is significant.…”

Section: Results Of the 57 Identified Studies Reporting On Symptoms Dmentioning

confidence: 99%

“…The identified 57 studies reported on 841 patients infected with Zika virus; a symptomatic rash was reported in 698 (83%) of these patients (Table 1a) . Pregnant patients were included in 17 studies, and there were 283 pregnant patients; a rash occurred in 256 (91%) patients (mostly during the 1st and 2nd trimester).…”

Section: Results Of the 57 Identified Studies Reporting On Symptoms Dmentioning

confidence: 99%

Skin manifestations are common and associated with a higher prevalence of congenital abnormalities in Zika virus infection

Worm

Khumalo

2017

Int J Dermatology

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“…Zika virus (ZIKV) was first isolated in Uganda in 1947 . ZIKV outbreaks have recently been described in Yap Island (2007), French Polynesia (2013), and Brazil (2015), reaching many countries in the Americas by 2016 . ZIKV is an arbovirus, belonging to the Flaviviridae family.…”

Section: Introductionmentioning

confidence: 99%

Efficiencies and kinetics of infection in different cell types/lines by African and Asian strains of Zika virus

Silva

Cheng

Huang

et al. 2018

Journal of Medical Virology

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After recent outbreaks, Zika virus (ZIKV) was linked to severe neurological diseases including Guillain-Barré syndrome in adults and microcephaly in newborns. The severities of pathological manifestations have been associated with different ZIKV strains. To better understand the tropism of ZIKV, we infected 10 human and four nonhuman cell lines (types) with two African (IbH30656 and MR766) and two Asian (PRVABC59 and H/FP/2013) ZIKV strains. Cell susceptibility to ZIKV infection was determined by examining viral titers, synthesis of viral proteins, and replication of positive and negative strands of viral genome. Among nonhuman cell lines, only Vero cells were efficiently infected by ZIKV. Among human cell lines, all were permissive to ZIKV infection. However, 293T and HeLa cells showed differential susceptibility towards African strains. In 293T cells, the NS1 protein was expressed at the high level by African strains but was almost not expressed by Asian strains though there was no obvious difference in viral genome replication, suggesting that the differential susceptibility might be controlled at the stage of viral protein translation. This study provides comprehensive results of the permissiveness of different cell types to both African and Asian ZIKV strains, which might help clarify their different pathogenesis.

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Transmission of Zika Virus — Haiti, October 12, 2015–September 10, 2016

Cited by 15 publications

References 2 publications

Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: A living systematic review

Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: A living systematic review

Skin manifestations are common and associated with a higher prevalence of congenital abnormalities in Zika virus infection

Efficiencies and kinetics of infection in different cell types/lines by African and Asian strains of Zika virus

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