From amino acids polymers, antimicrobial peptides, and histones, to their possible role in the pathogenesis of septic shock: a historical perspective

Ginsburg, Isaac; Heerden, Peter Vernon van; Koren, Erez

doi:10.2147/jir.s126150

Cited by 14 publications

(8 citation statements)

References 80 publications

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“…Meanwhile, the electrical conductivity of A. ochraceus increased by 28.3% and 28.8% after exposure to citral and geraniol, respectively, indicating that the integrity of the cell membrane was partially disrupted. When damage to the cell membrane occurred, more small molecules such as electrolytes were released, causing the higher electrical conductivity to accelerate cell death [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Antifungal Activity of Essential Oil Compounds (Geraniol and Citral) and Inhibitory Mechanisms on Grain Pathogens (Aspergillus flavus and Aspergillus ochraceus)

et al. 2018

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The grain contamination by Aspergillus spp. has been a serious issue. This study exhibited the excellent antifungal effects of the essential oil compounds (EOCs) geraniol and citral against common grain pathogens (A. flavus and A. ochraceus) in vitro and in situ. The inhibitory mechanisms were also evaluated from the perspective of cell membrane permeability, reactive oxygen species (ROS) generation, and Aspergillus spp. growth-related gene expression. Meanwhile, the combined effects of EOCs in the vapor phase and modified atmosphere packaging (MAP) were examined to find an alternative preservation method for controlling Aspergillus spp. The results indicated that citral exhibited the antifungal activity mainly by downregulating the sporulation- and growth-related genes for both pathogens. Geraniol displayed inhibitory effectiveness against A. flavus predominantly by inducing the intracellular ROS accumulation and showed toxicity against A. ochraceus principally by changing cell membrane permeability. Furthermore, the synthetic effects of EOCs and MAP (75% CO2 and 25% N2) induced better grain quality than the current commercial fumigant AlP. These findings reveal that EOCs have potential to be a novel grain preservative for further application.

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Section: Discussionmentioning

confidence: 99%

Antifungal Activity of Essential Oil Compounds (Geraniol and Citral) and Inhibitory Mechanisms on Grain Pathogens (Aspergillus flavus and Aspergillus ochraceus)

et al. 2018

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“…Short-polypeptide antimicrobial peptides called have a cationic characteristic and an amphipathic structure (usually no more than 60 amino acids). The majority of antimicrobial peptides operate as the first line of defense against a variety of pathogens, including bacteria, fungi, viruses, and protozoan parasites [29]. A recent analysis of publicly available patent data on the therapeutic use of antimicrobial peptides from 2003 to 2015 revealed that the majority of the claimed antimicrobial peptides were also described as the effective modulators of inflammation or neutralizers of pathogenic toxins in addition to being potent antibiotics [3, 30].…”

Section: Antimicrobial Peptidesmentioning

confidence: 99%

Targeting Matrix Metallopeptidase 9 (MMP-9) and Role of Quorum Sensing (QS) in Diabetic Foot Ulcers

Jifar¹

2023

Diabetic Foot - Recent Advances

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Diabetes-related foot ulcers (DFU) are a serious public health issue, and one of the main causes of death for diabetics is foot ulcers. Matrix metalloproteinase are crucial to both the pathophysiology of wounds and the healing process. MMPs have not previously been a focus for the treatment of DFUs due to the difficulty in differentiating between active MMPs and the two catalytically inactive forms of MMPs and the clinical failure of broad-spectrum MMP inhibitors in cancer. Managing bacterial infections by focusing on this quorum sensing (QS)-regulated process different from other management strategies. Despite the fact that the medical community has a thorough grasp of diabetic foot ulcers, research is continuously being done to find the most effective treatment for this crippling condition that is also safe to provide. Diabetic foot ulcers are brought on by a variety of factors, so a combination of therapies rather than a single medication will be the most effective course of treatment. This book chapter discusses the identification of active MMP-9 as the molecular cause of the diabetic wounds’ resistance to healing as well as the unique therapeutic strategy of inhibiting this proteinase and about role of inhibiting the quorum sensing (QS) system in the treatment of diabetic foot ulcer.

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“…Most AMP serve as the initial line of defense against the spread of a wide range of pathogens, including bacteria, fungus, viruses, and protozoan parasites. 31 – 33 Most AMPs are now utilized in clinical trials, and they are used to treat a variety of human ailments, including diabetic foot ulcers. For example, the Neuprex medicines (RBPI 21) are designated as orphan medications by the FDA.…”

Section: Current Approach To the Diabetic Foot Ulcers Managementmentioning

confidence: 99%

A Review: Matrix Metallopeptidase-9 Nanoparticles Targeted for the Treatment of Diabetic Foot Ulcers

Jifar¹,

Atnafie²,

Angalaparameswari³

2021

JMDH

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Diabetes foot ulcers are a leading cause of death in diabetic individuals. There are very few medicines and treatments that have received regulatory clearance for this indication, and numerous compounds from various pharmacological classes are now in various stages of clinical studies for diabetic foot ulcers treatment. Multiple risk factors contribute to diabetic foot ulcers, including neuropathy, peripheral artery disease, infection, gender, cigarette smoking, and age. The present difficulties in diabetic foot ulcers treatment are related to bacterial resistance to currently utilized antibiotics. Inhibition of the quorum sensing (QS) system and targeting matrix metallopeptidase-9 (MMP-9) are promising. This study focuses on the difficulties of existing treatment, current treatment technique, and novel pharmacological targets for diabetic foot ulcer. The electronic data base search diabetic for literature on foot ulcers treatment was carried out using Science Direct, PubMed, Google-Scholar, Springer Link, Scopus, and Wiley up to 2021. Becaplermin, a medication that targets MMP-9, glyceryl trinitrate, which inhibits the bacterial quorum sensing system, probiotic therapy, and nano technological solutions are just a few of the novel pharmaceuticals being developed for diabetic foot ulcers treatment. A combination of therapies, rather than one particular agent, will be the best option for treatment of Diabetes foot ulcer since it is multifactorial factors that render occurs of diabetic foot ulcer.

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From amino acids polymers, antimicrobial peptides, and histones, to their possible role in the pathogenesis of septic shock: a historical perspective

Cited by 14 publications

References 80 publications

Antifungal Activity of Essential Oil Compounds (Geraniol and Citral) and Inhibitory Mechanisms on Grain Pathogens (Aspergillus flavus and Aspergillus ochraceus)

Antifungal Activity of Essential Oil Compounds (Geraniol and Citral) and Inhibitory Mechanisms on Grain Pathogens (Aspergillus flavus and Aspergillus ochraceus)

Targeting Matrix Metallopeptidase 9 (MMP-9) and Role of Quorum Sensing (QS) in Diabetic Foot Ulcers

A Review: Matrix Metallopeptidase-9 Nanoparticles Targeted for the Treatment of Diabetic Foot Ulcers

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