Abstract:Diabetes-related foot ulcers (DFU) are a serious public health issue, and one of the main causes of death for diabetics is foot ulcers. Matrix metalloproteinase are crucial to both the pathophysiology of wounds and the healing process. MMPs have not previously been a focus for the treatment of DFUs due to the difficulty in differentiating between active MMPs and the two catalytically inactive forms of MMPs and the clinical failure of broad-spectrum MMP inhibitors in cancer. Managing bacterial infections by foc… Show more
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