Effects of Curcumin on Serum Vitamin E Concentrations in Individuals with Metabolic Syndrome

Abstract

Vitamin E is an important lipid-soluble antioxidant. The aim of the present study was to investigate the effect of curcumin on serum vitamin E levels in subjects with metabolic syndrome (MetS). A total of 120 subjects aged 18-65 years old with MetS were recruited in this study according to the International Diabetic Federation Criteria. Included subjects were randomized into three groups: subjects receiving lecithinized curcumin (1 g/day equivalent to 200-mg pure curcumin per day) for a period of 6 weeks )n = 40), patients receiving unformulated curcumin (1 g/day) for a period of 6 weeks )n = 40) and a control group receiving placebo for the same period (n = 40). Vitamin E was determined in all patients before and after the intervention using high-performance liquid chromatography method. Results showed that curcumin has no improving effect on serum levels of vitamin E (p > 0.05). There were significant differences between pre-trial and post-trial levels of vitamin E/low-density lipoprotein cholesterol ratio (p < 0.05), vitamin E/high-density lipoprotein cholesterol ratio (p < 0.05), vitamin E/total cholesterol ratio (p < 0.01) and vitamin E/triglyceride ratio (p < 0.05) between the three groups of the study. Results of the present study did not suggest any improving effect of curcumin supplementation on serum vitamin E concentrations in subjects with MetS. Copyright © 2017 John Wiley & Sons, Ltd.

Metabolic benefits of curcumin supplementation in patients with metabolic syndrome: A systematic review and meta‐analysis of randomized controlled trials

“…After duplicate removal, 60 records were excluded, and 84 studies were screened on the basis of titles and abstracts. From 21 studies selected for full‐text screening, 14 studies were excluded because of different types of supplement (Cicero et al, ; Rahimi et al, ; Kocher et al, ; Tariq et al, ), patients without a diagnosis of MetS (Campos‐Cervantes et al, ; Chuengsamarn et al, ; Esmaily et al, ; Ismail et al, ; Panahi, et al, ; Panahi, et al, ), lack of desired variables (Campos‐Cervantes et al, ), and reporting duplicate data (A. Mohammadi et al, ). Seven studies fulfilled inclusion criteria for quantitative data synthesis.…”

“…patients without a diagnosis of MetS(Campos-Cervantes et al, 2011;Chuengsamarn et al, 2012;Esmaily et al, 2015;Ismail et al, 2016;Panahi, et al, 2017a;Panahi, et al, 2017b), lack of desired variables (Campos-Cervantes et al, 2011), and reporting duplicate data (A Mohammadi et al, 2017)…”

Curcumin sensitized the antitumour effects of irradiation in promoting apoptosis of oesophageal squamous-cell carcinoma through NF-κB signalling pathway

“…Curcumin is a phyto‐polyphenolic pigment extracted from turmeric ( Curcuma longa ) . It has been widely used for therapeutic purpose histologically due to the intrinsic anti‐inflammatory, antioxidant and antitumour properties . The extensive investigations and exploitations have characterized the wide‐spectrum anticancer activity of curcumin against variety of human tumours including ovarian, breast, colon and so forth .…”

“…[9,10] It has been widely used for therapeutic purpose histologically due to the intrinsic anti-inflammatory, [11,12] antioxidant [13] and antitumour properties. [14][15][16][17][18][19] The extensive investigations and exploitations have characterized the wide-spectrum anticancer activity of curcumin against variety of human tumours including ovarian, breast, colon and so forth. [20][21][22][23][24][25] The various modes of action have been proposed underlying its therapeutic function in treatment of human cancer, including inhibition of proliferation, induction of cell apoptosis and suppression of angiogenesis.…”

Herbal medicinal products and obesity: A PTR virtual issue

“…Clinical trials focused on the effect of Ilex paraguariensis beverages on body weight and lipid profiles (Chaves et al, ), on the impact of green tea supplementation on anthropometric indices, including weight and body fat percentage in women with polycystic ovary syndrome (Mombaini, Jafarirad, Husain, Haghighizadeh, & Padfar, ), and finally, on the effect of quercetin supplementation (1 g/die) on metabolic and hormonal parameters in overweight or obese women with polycystic ovary syndrome (Khorshidi et al, ). Other clinical trials included in this virtual issues have described the effect of artichoke leaf extract and curcumin, a nutraceutical with a wide range of potential therapeutic applications (Kunnumakkara et al, ; Mantzorou, Pavlidou, Vasios, Tsagalioti, & Giaginis, ; Pagano, Romano, Izzo, & Borrelli, ; Soleimani, Sahebkar, & Hosseinzadeh, ) in subject with metabolic syndrome (Ghazimoradi et al, ; Mohammadi et al, ; Rezazadeh, Rahmati‐Yamchi, Mohammadnejad, Ebrahimi‐Mameghani, & Delazar, ).…”