Curcumin sensitized the antitumour effects of irradiation in promoting apoptosis of oesophageal squamous-cell carcinoma through NF-κB signalling pathway

Liu, Guiping; Li, Mingjun

doi:10.1111/jphp.12981

Cited by 16 publications

(9 citation statements)

References 40 publications

(79 reference statements)

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“…In vitro experiments with lung cancer cells showed down-regulation of EGFR-and NFkB-AKT-pathway leading to inhibition of proliferation, apoptosis induction and radiosensitization after Curcumin treatment 22,37 . Also in prostate cancer 23 , oesophageal cancer 38 and in head and neck squamous cell carcinoma cells 24 radiosensitization by Curcumin was observed and associated with its impact on NFkB-and EGFR-pathways. In pancreatic cancer cell lines radiation-induced NFkB activity was inhibited by Curcumin consequential leading to a significantly higher apoptosis induction 25 .…”

Section: Discussionmentioning

confidence: 95%

Modification of radiosensitivity by Curcumin in human pancreatic cancer cell lines

Schwarz

Dobiasch

Nguyen

et al. 2020

Sci Rep

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Pancreatic cancer is one of the most aggressive malignancies and is characterized by a low 5-year survival rate, a broad genetic diversity and a high resistance to conventional therapies. As a result, novel therapeutic agents to improve the current situation are needed urgently. Curcumin, a polyphenolic colorant derived from Curcuma longa root, showed pleiotropic influences on cellular pathways in vitro and amongst others anti-cancer properties including sensitization of tumor cells to chemo-and radiation-therapy. In this study, we evaluated the impact of Curcumin on the radiosensitivity of the established human pancreatic cancer cell lines Panc-1 and MiaPaCa-2 in vitro. In contrast to MiaPaCa-2 cells, we found a significant radiosensitization by Curcumin in the more radioresistant Panc-1 cells, possibly caused by cell cycle arrest in the most radiation-sensitive G2/M-phase at the time of irradiation. Furthermore, a significant enhancement of radiation-induced apoptosis, DNA-double-strand breaks and G2/M-arrest after curcumin treatment was observed in both cell lines. These in vitro findings suggest that especially patients with more radioresistant tumors could benefit from a radiationconcomitant, phytotherapeutic therapy with Curcumin.

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Section: Discussionmentioning

confidence: 95%

Modification of radiosensitivity by Curcumin in human pancreatic cancer cell lines

Schwarz

Dobiasch

Nguyen

et al. 2020

Sci Rep

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“…The expression of the proliferation marker Ki-67, angiogenesis markers (CD31 and VEGF), and NF-κB-regulated genes decreased in tumor tissues, leading to the enhanced susceptibility of cancer cells to radiation and suppression of tumor growth. Liu et al (2018a) also demonstrated that curcumin potentiated the anticancer effect of radiation in ESCC cell lines by inhibiting the NF-κB pathway. Treatment with curcumin in an irradiated environment promoted apoptosis induction in cancer cells and prolonged survival in xenograft mice.…”

Section: The Anticancer Mechanism Of Action Of Curcuminmentioning

confidence: 91%

The anticancer effects of curcumin and clinical research progress on its effects on esophageal cancer

Wang

Gao

et al. 2022

Front. Pharmacol.

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Esophageal cancer (EC) is a common tumor of the gastrointestinal system and a major threat to human health. The etiology and incidence of EC vary depending on the type of pathology. Owing to the unique physiological structure of the esophagus and the poor biological behavior of EC, the treatment modalities available are limited, and the prognosis of patients is relatively poor. Curcumin is a type of natural phytochemical belonging to the class of phenolic compounds. It exerts favorable anticancer effects on various cancers. A growing body of evidence indicates that curcumin suppresses tumor development and progression by inhibiting tumor cell proliferation, invasion, and migration, thus inducing apoptosis, regulating microRNA expression, reversing multidrug resistance, and inducing sensitivity to the therapeutic effect of chemoradiotherapy. Multiple cellular molecules, growth factors, and genes encoding proteins participating in different signaling pathways interact with each other to contribute to the complex and orderly anticancer effect. The efficacy and safety of curcumin have been established in preclinical studies for EC and clinical trials for other cancers. However, the low bioavailability of curcumin limits its clinical application. Therefore, the modification of curcumin analogs, the combination of curcumin with other drugs or therapies, and the use of novel nanocarriers have been widely investigated to improve the clinical effects of curcumin in EC.

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“…In five different human esophageal squamous cell lines ESCC-07, ESCC-12, ESCC-19, ESCC-27, and ESCC-31, curcumin increased radiation-induced apoptotic death primarily through inhibition of the NF-κB signaling pathway. Pretreatment with curcumin also suppressed tumor progression and decreased both the tumor volume and weight of ESCC-07 xenograft mice that were previously exposed to fractionated radiotherapy [ 51 ]. When low doses of curcumin (2.5 μΜ) were combined with radiation in human colon cancer HT-29 cells, a stronger inhibitory effect on cell proliferation was observed, due to modulation of expression of DNA repair-related genes, including Cyclin H (CCNH), DNA Ligase 4 (LIG4) and Polynucleotide Kinase 3′-Phosphatase (PNKP).…”

Section: Curcumin As a Radiosensitizer In Various Malignant Tumors An...mentioning

confidence: 99%

Radiosensitization and Radioprotection by Curcumin in Glioblastoma and Other Cancers

et al. 2022

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Radiation therapy plays an important role in almost every cancer treatment. However, radiation toxicity to normal tissues, mainly due to the generation of reactive free radicals, has limited the efficacy of radiotherapy in clinical practice. Curcumin has been reported to possess significant antitumor properties. Although curcumin can sensitize cancer cells to irradiation, healthy cells are much less sensitive to this effect, and thus, curcumin is thought to be a potent, yet safe anti-cancer agent. In this review, a summary of the role of curcumin as both a radiosensitizer and radioprotector has been presented, based on the most recent data from the experimental and clinical evaluation of curcumin in different cancer cell lines, animal models, and human patients.

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Curcumin sensitized the antitumour effects of irradiation in promoting apoptosis of oesophageal squamous-cell carcinoma through NF-κB signalling pathway

Cited by 16 publications

References 40 publications

Modification of radiosensitivity by Curcumin in human pancreatic cancer cell lines

Modification of radiosensitivity by Curcumin in human pancreatic cancer cell lines

The anticancer effects of curcumin and clinical research progress on its effects on esophageal cancer

Radiosensitization and Radioprotection by Curcumin in Glioblastoma and Other Cancers

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