Changes in bone turnover markers with HIV seroconversion and ART initiation

Slama, Laurence; Reddy, Susheel; Phair, John P.; Palella, Frank J.; Brown, Todd T.

doi:10.1093/jac/dkx011

Cited by 15 publications

(11 citation statements)

References 32 publications

(38 reference statements)

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“…While literature findings on adult patients provide contrasting results, showing both increase and decrease of bone formation markers [16, 17], studies on pediatric populations show an increase in both formation and resorption markers. In a study comparing 32 patients with vertically transmitted HIV, in ART (age 6.3-17.7 years), with healthy controls, Mora and colleagues reported higher values of BALP (formation marker) and NTX (resorption marker) in the HIV positive group [18].…”

Section: Discussionmentioning

confidence: 99%

Impact of HIV-1 Infection and Antiretroviral Therapy on Bone Homeostasis and Mineral Density in Vertically Infected Patients

Donà

Mozzo

Luise³

et al. 2019

Journal of Osteoporosis

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Daily assumption of antiretroviral drugs and HIV-related immune activation lead to important side effects, which are particularly evident in vertically infected patients. Bone homeostasis impairment and reduction of bone mineral density (BMD) is one of the most important side effects. Primary aim of this study is to assess the prevalence of bone homeostasis alterations in a group of vertically infected patients; secondary aim is to analyze the relationship between bone homeostasis alterations and anthropometric data, severity of HIV infection, and antiretroviral therapy. We studied 67 patients with vertically transmitted HIV-1 (aged 6-31 years), followed by the Pediatric Infectious Disease Unit of the University Hospital of Padua, Italy. We analyzed bone turnover markers (P1NP and CTx) and we performed lumbar spine and femoral dual energy X-ray absorption densitometry (DXA). Personal and anthropometric data and information on HIV-infection severity and antiretroviral therapy were collected for all patients. We found that BMD values recorded by DXA showed a significant correlation with age, race, BMI, physical activity, and antiretroviral therapy duration. P1NP was increased in 43% of patients, while CTX in 61% of them. P1NP alteration was related to age, race, BMI, physical activity, therapy duration, and ever use of protease inhibitors and nucleotide reverse transcriptase inhibitors. CTX alteration was found to be correlated only with age. In conclusion, our study confirms that a wide percentage of HIV vertically infected patients show reduced BMD and impaired bone homeostasis. Strict monitoring is needed in order to early identify and treat these conditions.

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Section: Discussionmentioning

confidence: 99%

Impact of HIV-1 Infection and Antiretroviral Therapy on Bone Homeostasis and Mineral Density in Vertically Infected Patients

Donà

Mozzo

Luise³

et al. 2019

Journal of Osteoporosis

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“…All articles in this category found significantly reduced BMD, altered bone metabolism, or higher rates of [30][31][32][33][34][35]. Four articles rated as moderate to high quality [30,[33][34][35]. Of note two further articles rated low to moderate quality (AXIS score 5-10), rendering them the two lowest rated articles in this review [31,32].…”

Section: Hiv Related Changes In Bone Mineral Density (Bmd)mentioning

confidence: 83%

Section: Hiv Related Changes In Bone Mineral Density (Bmd)mentioning

confidence: 96%

Health Challenges and Comorbidities Experienced by People Living with Human Immunodeficiency Virus in Developed Nations: A Systematic Review

2021

hiv

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Introduction:Studies have reported the prevalence, incidence and risk of health challenges and comorbidities experienced by people living with HIV (PLHIV) in developed countries. Yet, no systematic review to appraise and summate these studies exists. Methods: Electronic database searches included studies conducted in developed countries which reported health challenges and comorbidities in PLHIV compared to a HIV negative population. Critical appraisal was conducted using the Appraisal Tool for Cross Sectional Studies (AXIS). Results: Eligible studies (n = 51) were of moderate to high methodological quality (range: 7-19/20). PLHIV had increased rates or risk of ischaemic stroke, myocardial infarction, reduced bone mineral density, lung and anal cancer, chronic obstructive pulmonary disease, lung infections, and peripheral lipodystrophy. Conclusions: In developed countries several health challenges and comorbidities remain of greater concern in PLHIV compared to HIV negative individuals. Evidence for other comorbidities remains limited or inconclusive, and requires further research.

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“…HIV-infected patients are believed to be three times more likely to present osteoporosis than non-HIV-infected patients [23]. HIV infection and the use of antiretroviral drugs (ART) modifies the regulatory markers of bone absorption and resorption, leading to lower BMD [25].…”

Section: Discussionmentioning

confidence: 99%

Do HIV patients have mandibular osteoporotic alterations? A mandibular cortical index case-control study

Nagai¹,

Morita²,

Munhoz³

et al. 2020

BDS

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Objective: The objective of this study was to evaluate mandibular osteoporotic alterations in patients with HIV infection in comparison to non-HIV-infected patients using panoramic radiographs. Material and Methods: 26 HIV-infected patients and 142 non-HIV-infected patients (control group) were included in this study. Panoramic radiographs of the participants were assessed considering mandibular cortical index (MCI). Non-parametric comparisons between groups were performed, using Mann-Whitney test, at a level significance level of p= 0.05. Results: HIV-infected patients presented lower bone mineral density (BMD) at mandible, assessed by MCI in panoramic radiographs when compared to non-HIV-infected patients. The medication intake of HIV-infected patients was highly heterogeneous and could not be associated to the low BMD presented in the mandibular cortex. Conclusions: HIV-infected patients may present lower mandibular BMD than non-HIV-infected patients. Keywords Panoramic radiograph; osteoporosis; bone mineral density; HIV.

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Changes in bone turnover markers with HIV seroconversion and ART initiation

Abstract: HIV seroconversion was associated with decreased OC levels while ART initiation was associated with decreases in sclerostin, a negative regulator of bone formation. Our results suggest that both HIV infection and ART have an impact on bone metabolism in white men.

Cited by 15 publications

References 32 publications

Impact of HIV-1 Infection and Antiretroviral Therapy on Bone Homeostasis and Mineral Density in Vertically Infected Patients

Impact of HIV-1 Infection and Antiretroviral Therapy on Bone Homeostasis and Mineral Density in Vertically Infected Patients

Health Challenges and Comorbidities Experienced by People Living with Human Immunodeficiency Virus in Developed Nations: A Systematic Review

Do HIV patients have mandibular osteoporotic alterations? A mandibular cortical index case-control study

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