The values of cardio-ankle vascular and ankle-brachial indices in patients with carbohydrate metabolic disorders: The ESSE-RF study in the Kemerovo Region

Sumin, А. N.; Безденежных, Н. А.; Федорова, Н. В.; Щеглова, А. В.; Индукаева, Е. В.; Артамонова, Г. В.

doi:10.17116/terarkh2016881211-20

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…В основной группе выявили увеличение ПЗВД на 2,31 % сразу после лечения, на 2 %через 6 месяцев и на 0,83 % -через 12 месяцев. По данным большинства авторов, увеличение ПЗВД за счет прироста диаметра артерии на 2 % в результате лечения является достаточным, чтобы судить об улучшении эндотелиальной функции [17,22].…”

Section: результаты исследования и их обсуждениеunclassified

“…Таким образом, вопросы выбора наиболее специфичных маркеров для ранней диагностики ЭД и степени ее выраженности при ПОУГ в сочетании с оценкой ригидности магистральных артерий могут иметь прогностическую ценность в отношении анализа прогрессирования заболевания [17].…”

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Аntioxidant Status and Lipid Metabolism in Patients with Different Forms of Primary Open-Angle Glaucoma Progression

Малишевская

Киселева

Filippova³

et al. 2020

Oftalʹmologiâ

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Purpose: to study the antioxidant system and lipid status of serum and evaluate the effect of Cytoflavin on these characteristics in patients with progressive and stable primary open angle glaucoma (POAG).Patients and methods. 67 patients with advanced stage POAG were observed. The average age was 66.3 ± 1.5 years. According to the course of the glaucoma process all patients were randomized into 2 groups: the 1st group with the stable glaucoma (31 patients) and the 2nd group with rapidly progressive glaucoma (36 patients). The progression criteria of POAG were global ganglion cell loss volume (GLV) and perimetric index (mean deviation-MD). For assessment of the reactivity of the vascular endothelium, a test with reactive hyperemia was performed using ultrasound method. The assessment of oxidative stress (OS) including peroxides, malonyldialdehyde (MDA) and the total antioxidant capacity of serum (AOS) were evaluated. The investigations of lipid metabolism included the level of cholesterol total (CT), cholesterol of low-density lipoproteins cholesterol (LDL-C), high-density lipoproteins cholesterol (HDL-C), triglycerides (TG) and atherogenic index (AI).Results. In the 2nd group there was the significant decrease of the mean GLV indices compared to those in the 1st group (7.16 ± 2.5 и 1.06 ± 0.2, respectively, р < 0.001). The mild degree of endothelial dysfunction (ED) predominantly was detected in patients of the 1st group (69 % of cases). The moderate and marked ED were found in patients with progressive POAG (68 and 25 %, respectively). The high level of OS in serum was determined in 43 % of patients of the 1st group and in 69 % of patients of the 2nd group (significant increase of peroxides and MDA). In patients with progressive POAG the mean indices of lipid metabolism (CT, LDL-C, HDL-C, TG, AI) were significantly higher than in healthy subjects (р < 0.001). Cytoflavin had a positive effect on the vascular endothelium function, normalization of lipid metabolism and decrease of OS in serum with increasing AOS in patients with progressive POAG.Conclusion. The assessment of the indices of OS, AOS and lipid metabolism enable us to determine the risk of progression of POAG and evaluate of the effectiveness of treatment.

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Section: результаты исследования и их обсуждениеunclassified

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Аntioxidant Status and Lipid Metabolism in Patients with Different Forms of Primary Open-Angle Glaucoma Progression

Малишевская

Киселева

Filippova³

et al. 2020

Oftalʹmologiâ

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Structural and functional features of peripheral vasculature in patients with glaucoma

Малишевская¹,

Киселева²,

Filippova³

et al. 2020

Vestn. oftal'mol.

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Pashkovа¹,

Chudova²

2021

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Background. The purpose was to determine the frequency, risk factors of the development of diabetic myopathy in children with type 1 diabetes mellitus (DM1), and to create a mathematical model for predicting the formation of pathology. Materials and methods. The observation group consisted of 136 children with DM1. All children underwent a comprehensive clinical, instrumental, and laboratory examination and assessment of the state of skeletal muscles to determine the risk factors for the development of diabetic myopathy. The prognostic significance of individual signs as risk factors of the development of diabetic myopathy in children with DM1 was analyzed based on calculating the relative risk (RR) index. The most significant factors included informative signs with an RR value of more than 1.0. The binary logistic regression method was used to predict the likelihood of developing diabetic myopathy. Results. The complex study showed that the development of diabetic myopathy took place in 45 (33.1 %) children. Based on the calculation of the RR index, out of 29 potential predictors, 7 risk factors were selected that can influence the development of diabetic myopathy: sex, age, duration of the disease, glycated hemoglobin level, fat mass index (FMI), ankle-brachial index, and the presence of peripheral neuropathy. A logistic regression model was constructed for individual prediction of the likelihood of developing diabetic myopathy. The classification model capacity was 90.2 %. The model sensitivity and specificity is 80.0 %, which characterizes the excellent quality of the classification of predictors and the high significance of the identified factors of the development of diabetic myopathy in children with DM1. Conclusions. Diabetic myopathy is a common complication of diabetes mellitus in children and develops in 33.1 % of cases. The priority contribution of the development of diabetic myopathy in children with DM1 is the state of glycemic control, the duration of diabetes mellitus, the patient’s age, sex, the presence of diabetic peripheral polyneuropathy, peripheral circulatory disorders, and an increase in the IMF. The developed mathematical forecasting model allows calculating with a high probability of developing diabetic myopathy in children with diabetes mellitus and can be used to identify patients with a high risk of developing this complication for the timely implementation of diagnostic and preventive management.

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The values of cardio-ankle vascular and ankle-brachial indices in patients with carbohydrate metabolic disorders: The ESSE-RF study in the Kemerovo Region

Cited by 4 publications

References 24 publications

Аntioxidant Status and Lipid Metabolism in Patients with Different Forms of Primary Open-Angle Glaucoma Progression

Аntioxidant Status and Lipid Metabolism in Patients with Different Forms of Primary Open-Angle Glaucoma Progression

Structural and functional features of peripheral vasculature in patients with glaucoma

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