Fertility preservation practices in pediatric and adolescent cancer patients undergoing HSCT in Europe: a population-based survey

Diesch, Tamara; Rovó, Alicia; Weid, Nicolas von der; Faraci, Maura; Pillon, Marta; Dalissier, A; Dalle, J-H; Bader, Peter

doi:10.1038/bmt.2016.363

Cited by 28 publications

(17 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diesch et al found that patient counselling relied predominantly on existing SOPs from the treating clinic . This is in accordance with our observation.…”

Section: Discussionsupporting

confidence: 93%

“…Diesch et al found that patient counselling relied predominantly on existing SOPs from the treating clinic. 6 This is in accordance with our observation. The conduction of our study renewed focus on fertility and conveyed novel information to the treating physicians; this translated into enhanced fertility counselling at the study sites.…”

Section: Comparison With Similar Studiessupporting

confidence: 94%

“…In a retrospective study conducted in 2009 amongst adult childhood cancer survivors, only two out of 159 patients used cryopreservation . In 2017, Diesch et al reported that 39% of HSCT patients in Europe received counselling on fertility‐preserving measures, and 29% underwent a fertility‐preserving procedure . Time pressure, knowledge deficits, and the desire to avoid upsetting affected families can, inter alia, influence the way in which information is delivered by health care professionals .…”

Section: Introductionmentioning

confidence: 99%

“…5 In 2017, Diesch et al reported that 39% of HSCT patients in Europe received counselling on fertility-preserving measures, and 29% underwent a fertility-preserving procedure. 6 Time pressure, knowledge deficits, and the desire to avoid upsetting affected families can, inter alia, influence the way in which information is delivered by health care professionals. [7][8][9][10] Tedious cryobank visits and costs of fertility preservation pose additional barriers.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Fertility knowledge and associated empowerment following an educational intervention for adolescent cancer patients

et al. 2019

View full text Add to dashboard Cite

Introduction/Objectives Fertility preservation is a major concern for adolescent cancer patients; yet, educational gaps remain. Our intervention study examined whether specially designed educational materials regarding fertility preservation increase knowledge and empowerment of patients and parents. Methods Eleven paediatric‐oncological centres in four European countries agreed to enrol all eligible patients and parents in a questionnaire survey at 3 and 6 months after diagnosis. Treating physicians were surveyed on their medical consultation regarding fertility. Results Educational intervention increased knowledge in both patients (n = 113 and n = 101 in the control and intervention groups, respectively) and parents (n = 111 and n = 99 in the control and intervention groups, respectively), but the difference did not achieve statistical significance (knowledge difference patients: 5.6% (t0)/13.1% (t1); parents: 6.4% (t0)/3.8% (t1)). Parents of older patients (OR = 1.3, 95%CI = 1.1‐1.7) and higher educational groups (OR = 6.2, 95%CI = 2.1‐18.3) in the intervention group (OR = 1.9, 95%CI = 1.03‐3.7) achieved higher knowledge levels. Empowerment was significantly improved in both patients (p = 0.046, d = 0.27) and parents (p = 0.046, d = 0.48) in the intervention group. Discussion/Conclusions In our study, the use of specifically prepared flyers and brochures successfully raised the level of fertility preservation knowledge in parents of older patients as well as parents with higher educational levels. Overall, the intervention improved patient and parent empowerment. Subsequent projects will include simpler information and digital material to particularly reach out to younger and less educated individuals.

show abstract

“…Diesch et al found that patient counselling relied predominantly on existing SOPs from the treating clinic . This is in accordance with our observation.…”

Section: Discussionsupporting

confidence: 93%

Section: Comparison With Similar Studiessupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Fertility knowledge and associated empowerment following an educational intervention for adolescent cancer patients

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Only one third of them worked by a team while patients in other institutions were counselled only by oncohemathologist [40]. Another study showed similar results: in 38 centers which responded to their survey 39% of patients were councelled and only 29% received fertility preservation programs [41].…”

Section: Counsellingmentioning

confidence: 85%

Reproductive health of female childhood cancer survivors

Žulpaitė

Bumbulienė

2018

Ginekol Pol

View full text Add to dashboard Cite

Current treatment schemes of childhood cancer are usually effective enough to enable successful management of the disease. With the high rates of survival, another problem arises because patients often suffer much later from side effects of the toxic therapy. A common complication caused by cancer treatment is impairment of the female reproductive system including dysfunction of the hypothalamus and hypophysis, the killing of gonadal cells, and uterine injury. This may lead to altered pubertal timing, gonadotropin insufficiency or deficiency, acute ovarian failure, premature ovarian insufficiency, sexual dysfunction, and complicated pregnancy. The severity of these side effects depends a lot on the patient's age at treatment and the particularities of their chemo- and/or radiotherapy regimens. While some types of cancer require aggressive treatment, and therefore negative side effects cannot be avoided, strategies which preserve the patient's reproductive potential are essential. Such strategies are more established in the treatment of adult women, however there are also promising opportunities in the treatment of pediatric oncology patients. Ovar-ian transposition is already widely applied before pelvic radiotherapy. Cryopreservation of ovarian tissue, cryopreservation and in vitro maturation of immature oocytes, or cryopreservation of mature oocytes when the patient's age is appropriate, have also shown to have promising results in pediatric patients. Concurrent combinations of several techniques can also be successful. Counselling of pediatric patients and their families is challenging, and the urgent commencement of anticancer therapies often discourages attempts to preserve the girl's reproductive system. Given that successful methods of fertility preserva-tion are already accessible, it is crucial not to leave this topic aside at the time of diagnosis.

show abstract

Fertility issues, fertility preservation, and pregnancy outcome in long‐term survivors

Rovó

Loren

Thewis

et al. 2021

Blood and Marrow Transplantation Long Term Management

View full text Add to dashboard Cite

Fertility preservation practices in pediatric and adolescent cancer patients undergoing HSCT in Europe: a population-based survey

Cited by 28 publications

References 32 publications

Fertility knowledge and associated empowerment following an educational intervention for adolescent cancer patients

Fertility knowledge and associated empowerment following an educational intervention for adolescent cancer patients

Reproductive health of female childhood cancer survivors

Fertility issues, fertility preservation, and pregnancy outcome in long‐term survivors

Contact Info

Product

Resources

About