Risk of inflammatory bowel disease in patients with rosacea: Results from a nationwide cohort study in Taiwan

Wu, Chun Ying; Chang, Yun Ting; Juan, Chao Keui; Shieh, Jeng-Jer; Lin, Yu Pu; Liu, Han Nan; Lin, Jaw Town; Chen, Yi Ju

doi:10.1016/j.jaad.2016.11.065

Cited by 50 publications

(40 citation statements)

References 25 publications

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“…The association between inflammatory bowel disease (IBD) and rosacea is another topic of interest. A Taiwanese nationwide cohort study of over 89,000 patients with rosacea found an independent association with IBD incidence, as compared to matched controls [ 31 ]. This association has been replicated by Egeberg et al’s Danish study and Li et al’s prospective study in American women [ 30 , 32 ].…”

Section: The Gut-skin Connectionmentioning

confidence: 99%

“…In one theory, dysbiosis of intestinal bacteria results in activation of plasma kallikrein-kinin pathways, leading to downstream neurogenic inflammation [ 41 ]. Some authors have suggested that this may, in part, explain the effectiveness of antibiotics in rosacea therapy [ 31 ]. While the microbiome represents an important therapeutic target, it is important to recognize the marked variation of human intestinal microbiome among individuals.…”

Section: The Gut-skin Connectionmentioning

confidence: 99%

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Diet and rosacea: the role of dietary change in the management of rosacea

Weiss

Katta

2017

Dermatol Pract Concept

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Dietary change may play a role in the therapy of rosacea. Certain foods and beverages may act as “triggers” for rosacea exacerbations. These may be divided into heat-related, alcohol-related, capsaicin-related, and cinnamaldehyde-related. One potential pathogenic mechanism may be via the activation of transient receptor potential cation channels, which result in neurogenic vasodilatation. Further research is needed on the role of the gut skin connection in rosacea. Epidemiologic studies suggest that patients with rosacea have a higher prevalence of gastrointestinal disease, and one study reported improvement in rosacea following successful treatment of small intestinal bacterial overgrowth. While further research is required in this area, patients may be advised on measures to support a healthy gut microbiome, including the consumption of a fiber-rich (prebiotic) diet.

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Section: The Gut-skin Connectionmentioning

confidence: 99%

Section: The Gut-skin Connectionmentioning

confidence: 99%

Diet and rosacea: the role of dietary change in the management of rosacea

Weiss

Katta

2017

Dermatol Pract Concept

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“…The present study has several limitations to be considered. First, like the previous studies using the NHIRD on rosacea, not all data were verified in the NHIRD, and we were unable to evaluate the rosacea subtypes, severity and laboratory parameters. We were not able to elucidate whether these factors affect the associations with psychiatric disorders.…”

Section: Discussionmentioning

confidence: 72%

“…The higher prevalence of Helicobacter pylori infection and small intestinal bacterial overgrowth were found in patients with rosacea . Besides, rosacea patients have an increased risk of inflammatory bowel disease . In psychiatric research, significant progress has been made in the understanding of the interaction between GI tract and brain function, and the microbiota gut–brain axis is proposed .…”

Section: Discussionmentioning

confidence: 99%

“…[17][18][19][20] Besides, rosacea patients have an increased risk of inflammatory bowel disease. 21 In psychiatric research, significant progress has been made in the understanding of the interaction between GI tract and brain function, and the microbiota gut-brain axis is proposed. 22,23 Altered GI microbiota was demonstrated in psychiatric disorders, including depression, 24,25 schizophrenia and bipolar disorder, 26 and autistic spectrum disorders.…”

Section: Discussionmentioning

confidence: 99%

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Risk of psychiatric disorders in rosacea: A nationwide, population‐based, cohort study in Taiwan

Hung

Chiang

Chung

et al. 2018

The Journal of Dermatology

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Rosacea has been reported to be associated with psychiatric disorders. Nevertheless, a nationwide study of the relationship between rosacea and comorbid psychiatric diseases in an Asian population has not been conducted. The aim of this study was to clarify the role of rosacea in the various psychiatric disorders by using a nationwide database in Taiwan. Data were obtained from the National Health Insurance Research Database of Taiwan from 2000 to 2013. In total, 7881 patients with rosacea and 31 524 age‐ and sex‐matched controls were enrolled. Patients with rosacea tended to have more coexisting psychiatric disorders. After adjusting for age, sex, comorbidity and residence/regions, the adjusted hazard ratio (HR) of psychiatric disorders for patients with rosacea was 2.761 (95% CI = 2.650–2.877, P < 0.001). Among them, the highest adjusted HR are phobic disorder and obsessive–compulsive disorder of 7.841 (95% CI = 7.526–8.170, P < 0.001) and 6.389 (95% CI = 6.132–6.657, P < 0.001), respectively. The National Health Insurance Research Database of Taiwan does not include the information about rosacea subtypes, severity and laboratory parameters. In conclusion, rosacea is related to various psychiatric disorders. In addition to anxiety and depression, patients are also at increased risk of phobic disorder and obsessive–compulsive disorder.

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