The effects of vitamin B on the immune/cytokine network and their involvement in depression

Mikkelsen, Kathleen; Stojanovska, Lily; Apostolopoulos, Vasso

doi:10.1016/j.maturitas.2016.11.012

Cited by 118 publications

(90 citation statements)

References 129 publications

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“…The findings also reveal that there is a significant correlation between the intakes of vitamin B and an increase in the prevalence of depressive symptoms [38][39][40]. This has also been confirmed by other research studies [41,42].…”

Section: Discussionsupporting

confidence: 84%

The Impact of Nutrition and Intestinal Microbiome on Elderly Depression—A Systematic Review

2020

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The aim of this review is to systematically review the evidence whether proper nutrition has a positive impact on the prevention or decline of depressive symptoms among elderly people. In addition, possible connections between nutrition, microbiome, and serotonin molecules and its tryptophan precursor are discussed. The methodology follows the PRISMA guidelines, including the PRISMA flow chart. The authors systematically reviewed peer-review, English-written articles published in Web of Science and PubMed between 2013 and 2018. The findings of six original articles, detected on the set inclusion and exclusion criteria, indicate that there is an association between nutrition and depressive symptoms in the target group, i.e., that proper nutrition has a positive impact on the prevention or reduction of depressive symptoms among elderly people. The findings also reveal that there is a considerable correlation between the intakes of vitamin B and a decrease in the prevalence of depressive symptoms. Furthermore, sufficient nutrient intake of tryptophan appears to be an important factor in terms of nutrition and serotonin levels in the body. The authors consider it important to explore associations between the overall dietary intake and depression since diets are not consumed as individual nutrients. Returning to preventive approaches seems to be a rational way to promote the mental health of seniors. Future studies thus need to include interdisciplinary collaboration: from a good diagnosis of the disease by a psychiatrist, through an analysis of the need for nutrient metabolism by a biochemist to the development of a nutritional plan by a nutritional therapist. The limitations of this review consist in a relatively small number of the studies on this topic, including just few randomized controlled trials, which are a guarantee of efficacy and objectivity in comparison with cross-sectional studies.

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Section: Discussionsupporting

confidence: 84%

The Impact of Nutrition and Intestinal Microbiome on Elderly Depression—A Systematic Review

2020

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“…The methylation cycle is responsible for detoxification, immune function, mood and controlling inflammation. A defect in methylation function contributes to numerous chronic conditions, including, neurological conditions [7][8][9]. Monoamine oxidase plays a vital role in the inactivation of neurotransmitters and a dysfunction in monoamine oxidase is thought to be responsible for a number of psychiatric and neurological disorders, including schizophrenia, depression and MS [7,[10][11][12].…”

Section: Vitamin B and Healthmentioning

confidence: 99%

Is there a Link between Vitamin B and Multiple Sclerosis?

Nemazannikova

Mikkelsen

Stojanovska

et al. 2018

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Damage to the myelin sheath (demyelination) is one of the main manifestations of multiple sclerosis (MS). Interestingly, both MS and vitamin B deficiency results in severe myelin degeneration that leads to loss in neuronal signal transmission. Deficiency in vitamin B complex vary, although common symptoms include fatigue, increased oxidative stress, inflammation and demyelination. In particular, vitamin B12 (cobalamin) has triggered an increased attention for its role in the methylation process, involvement in myelination and remyelination and reversal of MS symptoms. Here we discuss the role of vitamin B complex (B1, B2, B3, B4, B5, B6, B7, B9, B12) in MS. The anti-inflammatory and re-myelinating attributes of vitamin B complex members are promising, although with limited clinical studies. Hence, there is an urgent need for larger scope studies to determine the role of vitamin B supplementation alone, or in combination with other therapeutic agents, in prevention or reversal of MS and aid in improved quality of life of MS patients.

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“…In fact, curcumin exhibits numerous bioactivities such as antioxidant, antimicrobial, and anticancer [8,9]. Riboflavin, also, acts as an antioxidant, and it is linked to several health benefits [10].…”

Section: Food Additivesmentioning

confidence: 99%