Carotenoid intake and risk of non-Hodgkin lymphoma: a systematic review and dose-response meta-analysis of observational studies

Chen, Feifei; Hu, Jiyi; Liu, Ping; Li, Jing; Wei, Zheng; Liu, Peng

doi:10.1007/s00277-016-2898-1

Cited by 26 publications

(21 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During the treatment of cardiovascular and eye diseases and cancer, the dose and the exposure time of β-carotene, lycopene, lutein, and zeaxanthin have been reported to be crucial [37]. α-Carotene intake might decrease the development of non-Hodgkin lymphoma [60]. α-Carotene concentration in the blood may be associated with the development of various cancers [30].…”

Section: Antioxidant Functions Of Carotenoids At Molecular Level For mentioning

confidence: 99%

The Biochemistry and Antioxidant Properties of Carotenoids

Merhan¹

2017

Carotenoids

View full text Add to dashboard Cite

Carotenoids are one of the most widespread pigment groups distributed in nature, and more than 700 natural carotenoids have been described so far, and new carotenoids are introduced each year. Carotenoids are derived from 4 terpenes, including totally 40 carbon atoms. Carotenoids are naturally synthesized by cyanobacteria, algae, plants, some fungi, and some bacteria, but not made by mammals. Lately, the beneficial properties of α-carotene, β-carotene, γ-carotene, lycopene, phytoene, phytofluene, lutein, zeaxanthin, β-cryptoxanthin, astaxanthin, and fucoxanthin carotenoids in prevention of various diseases, such as tumor formation, cardiovascular, and vision, have been documented due to their roles as antioxidants, activation in certain gene expression associated with cell-to-cell communication, provitamin A activity, modulation of lipoxygenase activity, and immune response. In this chapter, in addition to biochemical properties of carotenoids, how the structure of these molecules influences the oxidative stress in health and reducing the risk of formation of various diseases will be described.

show abstract

Section: Antioxidant Functions Of Carotenoids At Molecular Level For mentioning

confidence: 99%

The Biochemistry and Antioxidant Properties of Carotenoids

Merhan¹

2017

Carotenoids

View full text Add to dashboard Cite

show abstract

“…To date, more than 700 carotenoids have been identified (14) , but six (α-carotene, β-carotene, β-cryptoxanthin, lycopene and lutein/zeaxanthin) represent more than 95 % of the total carotenoids in human plasma (17) . Therefore, we considered the sum of these six carotenoids as the total serum carotenoids in this study.…”

Section: Interview Of Participantsmentioning

confidence: 99%

“…NHL (14) . Serum levels of carotenoids are considered valid biological markers of dietary intake (16) .…”

mentioning

confidence: 99%

Associations between serum carotenoid levels and the risk of non-Hodgkin lymphoma: a case–control study

Zhu

et al. 2020

Br J Nutr

View full text Add to dashboard Cite

Limited studies have investigated the effects of serum carotenoids on the risk of non-Hodgkin lymphoma (NHL) and the findings have been inconclusive. This study aims to assess the association between serum total or specific carotenoid levels and NHL risk. This 1:1 matched, hospital-based case-control study enrolled 512 newly diagnosed (within 1 month) NHL patients and 512 healthy controls who were matched by age (±5 years) and sex in Urumqi, China. Serum carotenoid levels were measured by high-pressure liquid chromatography. Conditional logistic regression showed that higher serum total carotenoid levels and their subtypes (e.g., α-carotene, β-carotene, β-cryptoxanthin, and lycopene) were dose-dependently associated with decreased NHL risk. The multivariable-adjusted odds ratios (ORs) and their 95% confidence intervals (CIs) for NHL risk for quartile 4 (vs. quartile 1) were 0.31 (0.22, 0.48; P for trend: <0.001) for total carotenoids, 0.52 (0.33, 0.79; P for trend: 0.003) for α-carotene, 0.63 (0.42, 0.94; P for trend: 0.031) for β-carotene, 0.73 (0.49, 1.05; P for trend: 0.034) for β-cryptoxanthin, and 0.51 (0.34, 0.75; P for trend: 0.001) for lycopene. A null association was observed between serum lutein+zeaxanthin and NHL risk (OR: 0.89, 95% CI: 0.57, 1.38; P for trend: 0.556). Significant interactions were observed after stratifying according to smoking status, and inverse associations were more evident among current smokers than past or never smokers for total carotenoids, α-carotene, and lycopene (P for heterogeneity: 0.047, 0.042, and 0.046). This study indicates that higher serum carotenoid levels might be inversely associated with NHL risk, especially among current smokers.

show abstract

“…Interesting results have also come from several meta-analyses investigating the potential of L as an anti-cancer compound. According to Chen et al L is associated with a decreased risk of non-Hodgkin lymphoma [ 178 ], whereas Ge et al observed a negative association between L intake and esophageal cancer risk [ 179 ]. Interestingly, in-vitro studies with L have not reported a cytotoxic effect against normal human colon cells, but a significantly reduced survival rate of colon cancer cells [ 180 ].…”

Section: Extra-eye Actionsmentioning

confidence: 99%

The Effect of Lutein on Eye and Extra-Eye Health

et al. 2018

View full text Add to dashboard Cite

Lutein is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health. In particular, lutein is known to improve or even prevent age-related macular disease which is the leading cause of blindness and vision impairment. Furthermore, many studies have reported that lutein may also have positive effects in different clinical conditions, thus ameliorating cognitive function, decreasing the risk of cancer, and improving measures of cardiovascular health. At present, the available data have been obtained from both observational studies investigating lutein intake with food, and a few intervention trials assessing the efficacy of lutein supplementation. In general, sustained lutein consumption, either through diet or supplementation, may contribute to reducing the burden of several chronic diseases. However, there are also conflicting data concerning lutein efficacy in inducing favorable effects on human health and there are no univocal data concerning the most appropriate dosage for daily lutein supplementation. Therefore, based on the most recent findings, this review will focus on lutein properties, dietary sources, usual intake, efficacy in human health, and toxicity.

show abstract

Carotenoid intake and risk of non-Hodgkin lymphoma: a systematic review and dose-response meta-analysis of observational studies

Cited by 26 publications

References 34 publications

The Biochemistry and Antioxidant Properties of Carotenoids

The Biochemistry and Antioxidant Properties of Carotenoids

Associations between serum carotenoid levels and the risk of non-Hodgkin lymphoma: a case–control study

The Effect of Lutein on Eye and Extra-Eye Health

Contact Info

Product

Resources

About