Low Prevalence of Vitamin D Insufficiency among Nepalese Infants Despite High Prevalence of Vitamin D Insufficiency among Their Mothers

Haugen, Johanne; Ulak, Manjeswori; Chandyo, Ram Krishna; Henjum, Sigrun; Thorne‐Lyman, Andrew L.; Ueland, Per Magne; Midtun, Øivind; Shrestha, Prakash; Strand, Tor A.

doi:10.3390/nu8120825

Cited by 22 publications

(23 citation statements)

References 44 publications

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“… 12 , 28 Inadequate level of vitamin D is the most common reason for women with osteoporosis, and progressive deficiency of this hormone may lead to secondary hyperparathyroidism. 28 Haugen et al 29 also reported high prevalence of vitamin D insufficiency (59.8%) and deficiency (14.0%) in young women from our country. Hence, estimation of vitamin D deficiency/insufficiency becomes mandatory before reporting bone status in young as well as postmenopausal women.…”

Section: Discussionsupporting

confidence: 63%

Effect of age and estrogen on biochemical markers of bone turnover in postmenopausal women: a population-based study from Nepal

Pardhe¹,

Pathak²,

Bhetwal³

et al. 2017

IJWH

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BackgroundOsteoporosis, a common disease worldwide, is characterized by low bone mass and architectural deterioration of bone tissue, leading to enhanced bone fragility and increase in fracture risks. Both menopause and aging are related factors leading to greater risk of bone disease, particularly among postmenopausal women. Hence, the main purpose of this study was to investigate the differences in biochemical markers of bone turnover and to evaluate the association of hormones and age-related factors with biochemical markers between pre- and postmenopausal women.MethodsA descriptive cross-sectional study was conducted over a period of 6 months among the female population of Dholahity community, Lalitpur, Nepal. A total of 496 healthy women were selected based on the questionnaire strategy. Among them, 244 were premenopausal and 252 were postmenopausal women. Different bone markers were evaluated as per the guideline provided by the reagent manufacturer, and hormonal assay, particularly estradiol level assessment, was performed by chemiluminescence immunoassay-based technique.ResultsA significant decrease in serum calcium level and estradiol level was observed in postmenopausal women as compared to premenopausal women, whereas a significant increase in serum phosphorus and alkaline phosphatase (ALP) levels was seen among postmenopausal (p<0.001). Age was significantly correlated with bone markers (ALP and calcium) in postmenopausal group (p<0.005), while there was no significant correlation in premenopausal group. In addition, there was significant positive correlation between calcium and estradiol in postmenopausal women, while ALP was negatively correlated with estradiol in that group. Further, no significant correlation was demonstrated between estradiol and bone markers in postmenopausal women in body mass index and age-adjusted partial correlation analysis.ConclusionTimely diagnosis of osteoporosis in women would be of significant benefit for effective care for required populations and help to minimize mortality rate and financial burden of our country.

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Section: Discussionsupporting

confidence: 63%

Effect of age and estrogen on biochemical markers of bone turnover in postmenopausal women: a population-based study from Nepal

Pardhe¹,

Pathak²,

Bhetwal³

et al. 2017

IJWH

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“…We did not include a healthy control group in this study, but we have data on vitamin D status in young children in the same area, both in children with less-severe pneumonia (28) and in healthy infants (31). In the study of children with lesssevere pneumonia the percentage of children with vitamin D insufficiency and deficiency was comparable to the findings in this study.…”

Section: Discussionsupporting

confidence: 50%

Vitamin D status is associated with treatment failure and duration of illness in Nepalese children with severe pneumonia

et al. 2017

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BACKGROUND: There is no consensus on optimal Vitamin D status. The objective of this study was to estimate the extent to which vitamin D status predicts illness duration and treatment failure in children with severe pneumonia by using different cutoffs for vitamin D concentration. METHODS:We measured the plasma concentration of 25(OH)D in 568 children hospitalized with World Health Organization-defined severe pneumonia. The associations between vitamin D status, using the most frequently used cutoffs for vitamin D insufficiency (25(OH)Do50 and o75 nmol/l), and risk for treatment failure and time until recovery were analyzed in multiple logistic regression and Cox proportional hazards models, respectively. RESULTS: Of the 568 children, 322 (56.7%) had plasma 25(OH) D levels ≥ 75 nmol/l, 179 (31.5%) had levels of 50-74.9 nmol/l, and 67 (%) had levels o50 nmol/l. Plasma 25(OH)D o50 nmol/l was associated with increased risk for treatment failure and longer time until recovery. CONCLUSION: Our findings indicate that low vitamin D status (25(OH)Do50 nmol/l) is an independent risk factor for treatment failure and delayed recovery from severe lower respiratory infections in children.

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“…In a study conducted in Nepal vitamin D deficiency (< 20 ng/ml) was observed in 81% of the pregnant women and serum calcium level was less than the desired value in 67% of the mothers [17]. Vitamin D deficiency is observed worldwide in all age groups [13][14][15][16][17][18]. Deficiency during pregnancy and childbirth poses more threat to health than in other periods of life [4-6, 19, 20].…”

Section: Discussionmentioning

confidence: 97%

“…Few studies showed high a prevalence of vitamin D deficiency in general population [15,16]. In a study conducted in Nepal vitamin D deficiency (< 20 ng/ml) was observed in 81% of the pregnant women and serum calcium level was less than the desired value in 67% of the mothers [17]. Vitamin D deficiency is observed worldwide in all age groups [13][14][15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of vitamin D deficiency in pregnant women and their babies in Bhaktapur, Nepal

et al. 2019

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Background: Vitamin D deficiency has been observed worldwide in pregnant women and their newborns. Maternal vitamin D deficiency can lead to deficiency in their newborn baby and has been linked with various complications during pregnancy and delivery. There is risk of premature delivery and it is associated with high neonatal mortality. Methods: Seventy-nine pregnant women who were admitted to the Siddhi Memorial Hospital for delivery and their newborn babies were enrolled in the study. Maternal blood samples were taken before delivery while umbilical cord blood samples of their babies were taken after delivery. Serum vitamin D level and calcium level were assessed by fluorescence immunoassay using Ichromax vitamin D kit and endpoint method, respectively in the Siddhi Memorial Hospital laboratory. Results: Mean +/− SD serum vitamin D and calcium levels in pregnant mother before delivery were 14.6 +/− 8.5 ng/ml and 8.0 +/− 0.5 mg/dl, respectively, and in the cord blood were 25.7 +/− 11.2 ng/ml and 8.6 +/− 0.9 mg/dl, respectively. Eighty-one percent of the mothers and 35.8% of their babies were found to have vitamin D deficiency. Although 97.5% of the pregnant women were taking calcium supplementation, serum calcium was found lower than the normal reference value in 67% of the pregnant women and 64.2% of their babies. There were a linear relationship between the maternal and baby's serum vitamin D (P < 0.001) and calcium (P < 0.001) levels. Conclusion: There is high prevalence of vitamin D and calcium deficiency in pregnant mothers and newborn babies in Bhaktapur, Nepal. Pregnant women need to be supplemented with adequate amounts of these nutrients.

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Low Prevalence of Vitamin D Insufficiency among Nepalese Infants Despite High Prevalence of Vitamin D Insufficiency among Their Mothers

Cited by 22 publications

References 44 publications

Effect of age and estrogen on biochemical markers of bone turnover in postmenopausal women: a population-based study from Nepal

Effect of age and estrogen on biochemical markers of bone turnover in postmenopausal women: a population-based study from Nepal

Vitamin D status is associated with treatment failure and duration of illness in Nepalese children with severe pneumonia

Prevalence of vitamin D deficiency in pregnant women and their babies in Bhaktapur, Nepal

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