The Roles of Mitochondrial Cation Channels Under Physiological Conditions and in Cancer

Szabó, Ildikò; Leanza, Luigi

doi:10.1007/164_2016_92

Cited by 2 publications

(2 citation statements)

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“…MCU is overexpressed in several type of cancer cells (e.g. Davis et al ., ; Peruzzo et al ., ; Bustos et al ., ) and has been implicated in cancer‐related processes, in particular in the control of migration and metastasis (Hall et al ., ; Tang et al ., ; Tosatto et al ., ; Szabo and Leanza, ).…”

Section: Inner Membrane Ion Channelsmentioning

confidence: 97%

“…An important opportunity for intervention to modulate these processes is offered by mitochondrial ion channels (reviews on mitochondrial channels; Brini et al ., ; Citi et al ., ; Krabbendam et al ., ; Mammucari et al ., ; O'Rourke, ; Ponnalagu and Singh, ; Szabo and Zoratti, ; Szewczyk et al ., ). These channels are especially important, at least in the contexts of cancer (Figure ) (for reviews, see Leanza et al ., 2013a, 2014b; Madamba et al ., ; Peruzzo et al ., ; Mazure, ; Szabo and Leanza, ; Shoshan‐Barmatz et al ., ), neurodegeneration (Rodriguez et al ., ; Rao et al ., ; Kalani et al ., ) and ischaemia (Balderas et al ., ; Testai et al ., ; Smith et al ., ). In the present review, we discuss the recent developments in the field of mitochondrial ion channels, especially from the point of view of their pharmacological targeting.…”

Section: Introductionmentioning

confidence: 99%

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Pharmacological modulation of mitochondrial ion channels

Leanza

Checchetto

Biasutto

et al. 2019

British J Pharmacology

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The field of mitochondrial ion channels has undergone a rapid development during the last three decades, due to the molecular identification of some of the channels residing in the outer and inner membranes. Relevant information about the function of these channels in physiological and pathological settings was gained thanks to genetic models for a few, mitochondria‐specific channels. However, many ion channels have multiple localizations within the cell, hampering a clear‐cut determination of their function by pharmacological means. The present review summarizes our current knowledge about the ins and outs of mitochondrial ion channels, with special focus on the channels that have received much attention in recent years, namely, the voltage‐dependent anion channels, the permeability transition pore (also called mitochondrial megachannel), the mitochondrial calcium uniporter and some of the inner membrane‐located potassium channels. In addition, possible strategies to overcome the difficulties of specifically targeting mitochondrial channels versus their counterparts active in other membranes are discussed, as well as the possibilities of modulating channel function by small peptides that compete for binding with protein interacting partners. Altogether, these promising tools along with large‐scale chemical screenings set up to identify new, specific channel modulators will hopefully allow us to pinpoint the actual function of most mitochondrial ion channels in the near future and to pharmacologically affect important pathologies in which they are involved, such as neurodegeneration, ischaemic damage and cancer. Linked Articles This article is part of a themed section on Mitochondrial Pharmacology: Featured Mechanisms and Approaches for Therapy Translation. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.22/issuetoc

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Section: Inner Membrane Ion Channelsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Pharmacological modulation of mitochondrial ion channels

Leanza

Checchetto

Biasutto

et al. 2019

British J Pharmacology

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Current Challenges of Mitochondrial Potassium Channel Research

Kulawiak

Szewczyk

2022

Front. Physiol.

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In this paper, the current challenges of mitochondrial potassium channels research were critically reviewed. Even though recent progress in understanding K+ traffic in mitochondria has been substantial, some basic issues of this process remain unresolved. Here, we focused on the critical discussion of the molecular identity of various mitochondrial potassium channels. This point helps to clarify why there are different potassium channels in specific mitochondria. We also described interactions of mitochondrial potassium channel subunits with other mitochondrial proteins. Posttranslational modifications of mitochondrial potassium channels and their import are essential but unexplored research areas. Additionally, problems with the pharmacological targeting of mitochondrial potassium channel were illustrated. Finally, the limitation of the techniques used to measure mitochondrial potassium channels was explained. We believe that recognizing these problems may be interesting for readers but will also help to progress the field of mitochondrial potassium channels.

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The Roles of Mitochondrial Cation Channels Under Physiological Conditions and in Cancer

Cited by 2 publications

References 146 publications

Pharmacological modulation of mitochondrial ion channels

Pharmacological modulation of mitochondrial ion channels

Current Challenges of Mitochondrial Potassium Channel Research

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