Irisin suppresses the migration, proliferation, and invasion of lung cancer cells via inhibition of epithelial-to-mesenchymal transition

Shao, Lei; Li, Huanjie; Chen, Jian; Song, Haibo; Zhang, Yuzhu; Wu, Fei; Wang, Wenjuan; Zhang, Wen; Wang, Fang; Li, Hui; Tang, Dongqi

doi:10.1016/j.bbrc.2016.12.084

Cited by 91 publications

(115 citation statements)

References 43 publications

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“…They also showed that irisin decreased the sensitivity of doxorubicin to liver cancer cells. In contrast to the above study, Shao et al, (2017) showed that irisin inhibited proliferation, migration and invasion of lung cancer cells. On the other hand, another study showed that the irisin suppresses the growth of pancreatic cancer cells (Liu et al, 2018).…”

Section: Relationship Between Prostate Volume and Irisin And Roc Anacontrasting

confidence: 79%

Can the Irisin be a Biomarker for Prostate Cancer? A Case Control Study

Aslan

Hakan

Eryılmaz

et al. 2020

Asian Pac J Cancer Prev

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Aim: There is much evidence of an association between cancer and irisin that is an adipokine. This study researched on the relationship between prostate cancer (PCa) and irisin levels, and whether irisin can be used as a biomarker in the diagnosis of PCa. Materials and Methods: For the study groups, 50 primary PCa patients and 30 healthy male subjects were included in the PCa and healthy control groups, respectively. All volunteers in the healthy control group were screened for prostate cancer and other malignancies and chronic diseases. Volunteers who were determine to be completely healthy were included for healthy control group. In the serum samples of the subjects were measured free PSA, total PSA and irisin levels. Irisin levels were compared separately in terms of the Gleason scores and T stage. In addition to intergroup comparisons, the ROC curve for the irisin was plotted and power analysis was performed. Results: Free and total PSA levels in the PCa group were significantly higher compared to the healthy control group (p<0.05). In addition, irisin levels in the PCa group were significantly lower than in the healthy control group (p<0.05). There was no significant difference between irisin levels in the groups classified in terms of Gleason scores (p>0.05). When the cutoff value was taken as 8.1, the sensitivity and specificity of irisin for PCa were as 80.5% and 90%, respectively. Conclusion: The results of this study indicate that the levels of irisin in the PCa group are considerably reduced and irisin may be used as a biomarker as well as free and total PSA.

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Section: Relationship Between Prostate Volume and Irisin And Roc Anacontrasting

confidence: 79%

Can the Irisin be a Biomarker for Prostate Cancer? A Case Control Study

Aslan

Hakan

Eryılmaz

et al. 2020

Asian Pac J Cancer Prev

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“…Irisin inhibits the migration, proliferation, and invasion of lung cancer cells and reduced the expression of EMT markers by inhibiting the PI3K/AKT pathway. From a mechanistic perspective, irisin can reverse the activity of epithelial-mesenchymal transition (EMT) and inhibits the expression of Snail via the PI3K/AKT pathway [56]. Specifically, irisin inhibited EMT and reduced the invasion of lung cancer cells via the PI3K/AKT/Snail pathway [56].…”

Section: Irisin Exerts Its Anti-metastatic Effects Via the Pi3k/akt Pmentioning

confidence: 99%

“…From a mechanistic perspective, irisin can reverse the activity of epithelial-mesenchymal transition (EMT) and inhibits the expression of Snail via the PI3K/AKT pathway [56]. Specifically, irisin inhibited EMT and reduced the invasion of lung cancer cells via the PI3K/AKT/Snail pathway [56]. Conversely however, increased irisin levels may have protective roles in liver cancer cells through partial activation of the PI3K/ AKT pathway, which may facilitate liver cancer progression and decrease the sensitivity to chemotherapy [57] ( Table 1).…”

Section: Irisin Exerts Its Anti-metastatic Effects Via the Pi3k/akt Pmentioning

confidence: 99%

New insights into the cellular activities of Fndc5/Irisin and its signaling pathways

et al. 2020

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Fndc5, a well-defined myokine and also identified as an adipokine, has a critical role in modulation of metabolism and protection against obesity. These important functions are mediated by irisin, a secretory peptide produced from proteolytic processing of Fndc5. The other beneficial physiological effects of irisin are alleviation of oxidative stress, neuroprotective effects, and anti-inflammatory properties and associated anti-metastatic effects. Fndc5/irisin exerts its biological effects through several intracellular signaling pathways. The major signaling pathway is thought to be MAPK signaling pathways which are involved in neural differentiation, browning of white adipocytes, as well as osteoblast proliferation and differentiation. Other essential functions of Fndc5/irisin are mediated through additional pathways including AMPK pathway, PI3K/AKT, and STAT3/Snail. Thorough understanding of the mechanisms of irisin actions are essential in order to develop Fndc5/irisin for therapeutic purposes. In the present review, we focus on the current knowledge of the signaling pathways that elicit irisin actions.

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“…(1) Irisin inhibited metastasis by the suppression of EMT through the STAT3/Snail pathway. Shao et al 26 Liver cancer SMCC7721…”

Section: Model Findings Referencesmentioning

confidence: 99%

Pathophysiological role of endogenous irisin against tumorigenesis and metastasis: Is it a potential biomarker and therapeutic?

et al. 2019

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In the last few decades, there has been notable progress in understanding the molecular and cellular basis of the complex process involved in cancer. In this context, tumor-promoting inflammation, dysregulation of apoptotic signaling, tissue invasion and metastasis, and cancer microenvironment have recently attracted interest from researchers. Irisin is a hormone released by muscles during exercise and it directly acts on key functional cells involving energy metabolism and homeostasis. Recently, many studies have reported the anticancer effect of irisin against different types of cancer. Translation of these findings to clinical practice for the diagnosis and treatment of several types of cancer is urgently required. In this review, we summarized preclinical and clinical studies on the anticancer effects of irisin in various types of cancer, and also discussed the mechanisms activated by irisin to suppress cancer pathogenesis. We further discussed the serum level of irisin related to different types of cancer to understand more clearly the association between irisin concentration and tumor burden. This review may serve as a solid foundation for researchers and physicians to support basic and clinical studies on irisin as a promising strategy for early diagnosis and treatment of a various types of cancers.

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Irisin suppresses the migration, proliferation, and invasion of lung cancer cells via inhibition of epithelial-to-mesenchymal transition

Cited by 91 publications

References 43 publications

Can the Irisin be a Biomarker for Prostate Cancer? A Case Control Study

Can the Irisin be a Biomarker for Prostate Cancer? A Case Control Study

New insights into the cellular activities of Fndc5/Irisin and its signaling pathways

Pathophysiological role of endogenous irisin against tumorigenesis and metastasis: Is it a potential biomarker and therapeutic?

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