Pathophysiological role of endogenous irisin against tumorigenesis and metastasis: Is it a potential biomarker and therapeutic?

Sumsuzzman, Dewan Md.; Jin, Yunho; Choi, Jeong-Hyun; Yu, Jeong-Hee; Lee, Tae Ho; Hong, Yonggeun

doi:10.1177/1010428319892790

Cited by 12 publications

(13 citation statements)

References 50 publications

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“…As mentioned above, irisin is a type I transmembrane messenger protein that is mainly secreted by the skeletal muscle and stimulates “browning” and thermogenesis in fat tissue [ 53 ] and induces changes in different tissues in response to exercise [ 39 , 44 ]. Currently, there is no irisin receptor identified.…”

Section: Irisinmentioning

confidence: 99%

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Current Evidence of the Role of the Myokine Irisin in Cancer

Tsiani

Tsakiridis

Kouvelioti

et al. 2021

Cancers

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Cancer is a disease associated with extreme human suffering, a huge economic cost to health systems, and is the second leading cause of death worldwide. Regular physical activity is associated with many health benefits, including reduced cancer risk. In the past two decades, exercising/contracting skeletal muscles have been found to secrete a wide range of biologically active proteins, named myokines. Myokines are delivered, via the circulation, to different cells/tissues, bind to their specific receptors and initiate signaling cascades mediating the health benefits of exercise. The present review summarizes the existing evidence of the role of the myokine irisin in cancer. In vitro studies have shown that the treatment of various cancer cells with irisin resulted in the inhibition of cell proliferation, survival, migration/ invasion and induced apoptosis by affecting key proliferative and antiapoptotic signaling pathways. However, the effects of irisin in humans remains unclear. Although the majority of the existing studies have found reduced serum irisin levels in cancer patients, a few studies have shown the opposite. Similarly, the majority of studies have found increased levels of irisin in cancer tissues, with a few studies showing the opposite trend. Clearly, further investigations are required to determine the exact role of irisin in cancer.

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Section: Irisinmentioning

confidence: 99%

“…The studies are presented chronologically, and summary data tables are included. It should be noted that a number of related past reviews exist [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ]; however, the present review provides updated information and adds to the existing literature.…”

Section: Introductionmentioning

confidence: 99%

Current Evidence of the Role of the Myokine Irisin in Cancer

Tsiani

Tsakiridis

Kouvelioti

et al. 2021

Cancers

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“…Irisin was found to contrast denervation and oxidative stress [27,116], suggesting a beneficial role in ALS. Recent studies showed that irisin expression increased in patients affected by metabolic disorders and cancer cachexia [117]. Moreover, it was found increased in blood of ALS patients with great disability [118].…”

Section: Preclinical Studies and Proposed Drugs Able To Restore Skele...mentioning

confidence: 99%

“…Conversely, expression of irisin was reduced in patients with type 2 diabetes and non-alcoholic fatty liver disease. Most recent studies have demonstrated that serum irisin concentration was reduced in patients with breast cancer and exerts inhibitory effect on malignant breast cancer cells [117]. In this regard, further study of these pathways may be useful to assess the role of this myokine in a situation of inactivity such as ALS.…”

Section: Preclinical Studies and Proposed Drugs Able To Restore Skele...mentioning

confidence: 99%

Therapeutic Targets in Amyotrophic Lateral Sclerosis: Focus on Ion Channels and Skeletal Muscle

Tarantino

Canfora

Camerino

et al. 2022

Cells

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Amyotrophic Lateral Sclerosis is a neurodegenerative disease caused by progressive loss of motor neurons, which severely compromises skeletal muscle function. Evidence shows that muscle may act as a molecular powerhouse, whose final signals generate in patients a progressive loss of voluntary muscle function and weakness leading to paralysis. This pathology is the result of a complex cascade of events that involves a crosstalk among motor neurons, glia, and muscles, and evolves through the action of converging toxic mechanisms. In fact, mitochondrial dysfunction, which leads to oxidative stress, is one of the mechanisms causing cell death. It is a common denominator for the two existing forms of the disease: sporadic and familial. Other factors include excitotoxicity, inflammation, and protein aggregation. Currently, there are limited cures. The only approved drug for therapy is riluzole, that modestly prolongs survival, with edaravone now waiting for new clinical trial aimed to clarify its efficacy. Thus, there is a need of effective treatments to reverse the damage in this devastating pathology. Many drugs have been already tested in clinical trials and are currently under investigation. This review summarizes the already tested drugs aimed at restoring muscle-nerve cross-talk and on new treatment options targeting this tissue.

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“…It suppresses tumor-promoting inflammation, inhibits metastasis, and increases apoptosis. 142 Skeletal muscle is the main source of irisin secretion (about 72%), 139 and age-related sarcopenia may decrease circulating irisin levels in the elderly. 143 On the other hand, exercise may have a potential to induce irisin's secretion 139,144 which could contribute to its tumor-suppressing effects.…”

Section: Do We Know How Exercise Fights Chemotherapy Related Toxicity?mentioning

confidence: 99%

Chemotherapy‐induced toxicity in patients with testicular germ cell tumors: The impact of physical fitness and regular exercise

et al. 2021

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Background: Testicular germ cell tumors (TGCTs) represent ∼95% of testicular malignancies and are the most common type of malignancy in young male adults. While the incidence of TGCTs has increased during the last decades, the advances in treatment, namely introducing cisplatin into the chemotherapy regimen, have made TGCTs highly curable with the 10-year survival rate exceeding 95%. However, in parallel with increased cure rates, survivors may experience acute and late adverse effects of treatment, which increase morbidity, reduce the quality of life, and can be potentially lifethreatening. Chemotherapy-related toxicities include cardiovascular and metabolic diseases, secondary cancer, avascular necrosis, cognitive impairment, cancer-related fatigue, poor mental health-related quality of life, nephrotoxicity, hypogonadism, neurotoxicity, pulmonary toxicity, anxiety, and depression. These treatment-related adverse effects have emerged as important survivorship dilemmas in TGCT cancer survivors. Recently, regular physical exercise has increasingly attracted research and clinical attention as an adjunct therapy for cancer patients.Purpose: Herein, we review the most common chemotherapy-related adverse effects in TGCT survivors and clinical relevance of exercise and increased cardio-respiratory fitness in modulating chemotherapy-related toxicity and quality of life in this population. Results and conclusion:Exercise has positive effects on a spectrum of physical and psychosocial outcomes during and after cancer treatment, and current guidelines on exercise prescription in chronic diseases define the recommended dose (volume and

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Pathophysiological role of endogenous irisin against tumorigenesis and metastasis: Is it a potential biomarker and therapeutic?

Cited by 12 publications

References 50 publications

Current Evidence of the Role of the Myokine Irisin in Cancer

Current Evidence of the Role of the Myokine Irisin in Cancer

Therapeutic Targets in Amyotrophic Lateral Sclerosis: Focus on Ion Channels and Skeletal Muscle

Chemotherapy‐induced toxicity in patients with testicular germ cell tumors: The impact of physical fitness and regular exercise

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