Lipid Peroxidation and Altered Antioxidant Profiles with Pediatric HIV Infection and Antiretroviral Therapy in Addis Ababa, Ethiopia

Abstract

HIV- and highly active antiretroviral therapy (HAART)-associated elevations in oxidative stress likely play a role in incomplete immune reconstitution, opportunistic infections and non-AIDS co-morbidities. We aimed to test the hypothesis that children living with HIV exhibit elevated markers of oxidative stress and reduced antioxidant profiles and that HAART-therapy will exacerbate these differences. HIV-positive HAART-naïve (n = 50) and HAART-treated (n = 50) and HIV-negative control (n = 50) participants, 3-15 years of age, were recruited from Black Lion Hospital in Ethiopia. Serum malondialdehyde (MDA) and bilirubin were higher and vitamin C and zinc were lower in HAART-naïve and HAART-treated compared with HIV-negative subjects and higher in HAART-treated compared with HAART-naïve subjects. Uric acid was higher in HAART-naïve compared with HAART-treated and HIV-negative subjects. Differences in MDA and several antioxidants were also observed across treatment regimens. Thus, children living with HIV exhibited systemic elevations in oxidative stress and reduction in antioxidants, which are exacerbated with HAART therapy.

Nephrotoxicity and highly active antiretroviral therapy: Mitigating action of Momordica charantia

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Occupational cancer risk surveillance in HIV-infected individuals exposed to chemicals: Role of p53 molecular marker

“…Notably, the current study underscored the influence of both HIV infection and chemical exposures on cellular pathways associated with oxidative stress and apoptosis. The majority of prior studies focused on the influence of HIV infection or occupational exposure on oxidative stress indicators in isolation [54,56]. However, it is imperative to acknowledge the study's limitations.…”

Oxidative stress in HIV infection and its effects on the female reproductive system and pregnancy

“…В настоящее время проведен ряд исследований, посвященных изучению состояния системы ПОЛ и активности антиоксидантной защиты крови при различных заболеваниях [32][33][34][35][36][37][38][39], в том числе при ВИЧ-инфекции [40][41][42][43][44][45][46]. Однако данные по изучению параметров системы ПОЛ-АОз (антиоксидантная защита) ВИЧ-инфицированных беременных немногочисленны [47,48].…”