Soft tissue injuries are still a challenge in musculoskeletal sports and exercise medicine

Malliaropoulos, Nikos; Ghrairi, Mourad; Zerguini, Yacine; Padhiar, Nat

doi:10.1136/bjsports-2016-097171

Cited by 5 publications

(1 citation statement)

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“…In musculoskeletal sports and exercise, medicine soft tissue injuries are still a challenge, and one of the most common and challenging injuries was occurred in the tendon-to-bone interface. [28,29] The tendon-to-bone interface, such as the rotator cuff, is the transitional region composed of four distinct zones: the tendon, nonmineralized and mineralized fibrocartilage, and bone. [30] In the transitional region, the composition gradient is a distinct feature.…”

Section: Introductionmentioning

confidence: 99%

Bipolar Metal Flexible Electrospun Fibrous Membrane Based on Metal–Organic Framework for Gradient Healing of Tendon‐to‐Bone Interface Regeneration

Yang

Zheng

Yin

et al. 2022

Adv Healthcare Materials

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Metal ions play a significant role in tissue repair, with widely application in clinical treatment. However, the therapeutic effect of metal ions is always limited due to metabolization and narrow repair capability. Here, a bipolar metal flexible electrospun fibrous membrane based on a metal–organic framework (MOF), which is bioinspired by the gradient structure of the tendon‐to‐bone interface, with a combination of regulating osteoblasts differentiation and angiogenesis properties, is constructed successfully by a continuous electrospinning technique and matching the longitudinal space morphology for synchronous regeneration. Furthermore, the MOF, acting as carriers, can not only achieve the sustainable release of metal ions, but promote the osteogenesis and tenogenesis on the scaffold. The in vitro data show that this novel hierarchical structure can accelerate the tenogenesis, the biomineralization, and angiogenesis. Moreover, in the in vivo experiment, the flexible fibrous membrane can promote tendon and bone tissue repair, and fibrocartilage reconstruction, to realize the multiple tissue synchronous regeneration at the damaged tendon‐to‐bone interface. Altogether, this newly developed bipolar metal flexible electrospun fibrous membrane based on a MOF, as a new biomimetic flexible scaffold, has great potential in reconstruct the tissue damage, especially gradient tissue damage.

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Section: Introductionmentioning

confidence: 99%