Lipid Accumulation Product (LAP) as an Index of Metabolic and Hormonal Disorders in Aging Men

Rotter, Iwona; Rył, Aleksandra; Szylińska, Aleksandra; Pawlukowska, Wioletta; Lubkowska, Anna

doi:10.1055/s-0042-116071

Cited by 21 publications

(16 citation statements)

References 40 publications

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“…Therefore, MRI should be performed for these subjects to exclude other evidence of pituitary or hypothalamic disease. With regard to deteriorated metabolic profiles in ageing men, Rotter et al 24 indicated that the LAP was negatively associated with TT and SHBG in 313 men aged 50–75 years old, emphasising that the LAP is applicable in the evaluation of age-related testosterone deficiency. However, their study did not assess the symptoms of androgen insufficiency by standardised questionnaire.…”

Section: Discussionmentioning

confidence: 99%

Lipid accumulation product and late-onset hypogonadism in middle-aged and elderly men: results from a cross-sectional study in China

et al. 2020

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ObjectivesHypogonadism in men is related to the deterioration of general health. However, the association between lipid overaccumulation and ageing-related hypogonadism remains an undetermined concept. We aimed to provide an insight into the possible links between the lipid accumulation product (LAP) and late-onset hypogonadism (LOH).SettingSun Yat-sen Memorial Hospital of Sun Yat-sen University.ParticipantsWe included a population sample of 997 subjects aged 40 years or older.Primary and secondary outcome measuresThe LAP was calculated by gender-specific equations using waist circumference (WC) and triglyceride (TG). LOH was defined by the presence of androgen deficiency symptoms and low serum total testosterone levels.ResultsThe prevalence of LOH was 9.4% in this population and gradually increased according to increasing LAP quartiles. Compared with subjects without LOH, ageing men with LOH had higher body mass index, WC, systolic blood pressure, percentage of subjects currently smoking, TG and follicle stimulating hormone and lower low-density lipoprotein cholesterol and sex hormone binding globulin. In multivariate logistic regression analysis, the adjusted ORs of LOH for increasing LAP quartiles 1–4 were 1.00 (reference), 1.10 (95% CI 0.45–2.69), 2.15 (95% CI 0.93–4.94) and 3.83 (95% CI 1.73–8.45), respectively.ConclusionBody lipid accumulation evaluated by the LAP is independently associated with the prevalence of LOH in middle-aged and elderly Chinese men.

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Section: Discussionmentioning

confidence: 99%

Lipid accumulation product and late-onset hypogonadism in middle-aged and elderly men: results from a cross-sectional study in China

et al. 2020

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“…Moreover, hypertriglyceridemia was associated with an increased risk for cardiovascular diseases [ 53 ]. Rotter et al [ 54 ] studied the relationship between LAP and metabolic syndrome and its components, the results showed that LAP was significantly positively correlated with serum total cholesterol, FPG, insulin, but negatively correlated with HDL in elderly men. Therefore, the LAP that derives from WC and TG is believed to be a better predictor of hypertension risk and suitable in clinical application.…”

Section: Discussionmentioning

confidence: 99%

The effect of lipid accumulation product and its interaction with other factors on hypertension risk in Chinese Han population: A cross-sectional study

et al. 2018

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ObjectivesLipid accumulation product (LAP) is a simple and effective indicator that reflects visceral obesity. This study aimed to compare the significance of LAP in predicting hypertension risk with other obesity indices, and to evaluate the interactive effects of LAP and smoking, family history of hypertension on hypertension risk in Chinese Han adults.MethodsA community based cross-sectional study was performed in Bengbu, China. Participants received face-to-face questionnaire survey, anthropometric tests and laboratory examinations. Relevant indicators that reflect obesity including BMI (body mass index), waist-to-height ratio (WHtR) and LAP were calculated. Multivariate logistic regression analysis was applied to explore the association between LAP and hypertension risk. The area under the receiver-operating characteristics curves (AUC) of LAP, BMI, and WHtR were calculated and then compared. Interactive effect was evaluated by relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP) and synergy index (SI).ResultsA total of 1777 participants were enrolled, and the prevalence of hypertension was 24.4% (n = 433). There was a significant increase in hypertension risk with LAP levels in the fourth quartile as compared with the bottom quartile (OR: 3.31, 95%CI: 1.76–6.25). The AUC of LAP was significantly different than that of BMI in males (Z = 2.158, p = 0.0309) and females (Z = 3.570, p = 0.0004), while only performed better in females as compared with that of WHtR (Z = 2.166, p = 0.0303). LAP was significantly interacted with family history of hypertension on hypertension risk both in males (RERI: 1.07, 95%CI: 0.09–2.05; AP: 0.33, 95%CI: 0.23–0.44; SI: 1.92, 95%CI: 1.53–2.41) and females (RERI: 0.80, 95%CI: 0.07–1.53; AP: 0.25, 95%CI: 0.11–0.39; SI: 1.59, 95%CI: 1.16–2.19). However, a significant interaction between LAP and smoking was only observed in males (RERI: 1.32, 95%CI: 0.15–2.75; AP: 0.40, 95% CI: 0.14–0.73).ConclusionIncreased LAP was significantly associated with a higher risk of hypertension in Chinese Han adults. Moreover, the effect of LAP on predicting hypertension risk was better than that of other obesity indices. Our results also demonstrated interactive effects of LAP with smoking, family history of hypertension on hypertension risk.

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“…The irradiation of living things, known to induce the formation of free radicals, shorten their lifespan and produce changes that resemble ageing [4,5]. Involvement of free radicals in ageing has increased progressively and is becoming one of the more plausible theories of the ageing process [6,7]. It is believed that the antioxidant defense is generally weakened in old age.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Swimming Training in Cold Water on Antioxidant Enzyme Activity and Lipid Peroxidation in Erythrocytes of Male and Female Aged Rats

Lubkowska

Bryczkowska

Gutowska

et al. 2019

IJERPH

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The aim of this study was to verify whether eight-week-long swimming exercise training would evaluate the level of selected indicators of the pro-oxidant/antioxidant status in response to cold water in comparison with swimming under thermoneutral conditions in sedentary male and female elderly rats. The exercise-trained groups swam four min/day and five days a week during eight weeks of housing. Exercise was performed by swimming in glass tanks containing tap water maintained according to group at 5 °C and 36 °C. At the end of treatment (48 h after the last session), all rats were anaesthetized. The level of chosen biomarkers of oxidative stress and antioxidant enzyme activity was determined in the red blood cells and plasma. The results of study show that female rats seem to be better adapted to changing thermal conditions of the environment, developing not only morphological, but also antioxidant, defense mechanisms, mainly in the form of increased erythrocyte superoxide dismutase (SOD) activity and glutathione (GSH) concentration to restore the pro-oxidant/oxidant balance of the organism. Significantly higher concentrations of GSH were observed in the female rats of the group swimming in cold water (by 15.4% compared to the control group and by 20.5% in relation to the group of female rats swimming at 36 °C). In the group exposed to swimming training exercise in cold water, a significantly higher activity of SOD1 (by 13.4%) was found compared to the control group. On the other hand, the organs of ageing male rats show a reduced capacity to increase the metabolic response to low temperatures compared to female ones. In addition, it was demonstrated that cold exposure leads to an increase in lipid peroxidation in tissues. On the other hand, the repeated exposure to low levels of oxidative stress may result in some adaptive changes in organisms that help them to resist stress-induced damage.

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Lipid Accumulation Product (LAP) as an Index of Metabolic and Hormonal Disorders in Aging Men

Cited by 21 publications

References 40 publications

Lipid accumulation product and late-onset hypogonadism in middle-aged and elderly men: results from a cross-sectional study in China

Lipid accumulation product and late-onset hypogonadism in middle-aged and elderly men: results from a cross-sectional study in China

The effect of lipid accumulation product and its interaction with other factors on hypertension risk in Chinese Han population: A cross-sectional study

The Effects of Swimming Training in Cold Water on Antioxidant Enzyme Activity and Lipid Peroxidation in Erythrocytes of Male and Female Aged Rats

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